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  • Oxford University Press  (6)
  • American Chemical Society  (4)
  • AOSIS Publishing  (3)
  • National Academy of Sciences
  • Wiley-Blackwell
  • 2020-2024  (14)
Collection
Language
Years
Year
  • 1
    Publication Date: 2024-04-06
    Description: This book endeavours to outline case studies that promote sustainable Local Economic Development (LED) initiatives. It is generally believed that local governments are the foot soldiers of LED. However, this seems to be a myth, as local governments in South Africa and elsewhere have not yet fulfilled this mandate and have been struggling for several years to implement LED initiatives. The distinctive merit of this book lies in the way it combines the South African context with the wider international development context in ways that there is a flow of information and ideas both ways. The book is an essential part of this sequence of ideas development and action at a critical time for strategic action directed at a sustainable future. It showcases case studies and responses to the impacts of globalisation as a bridge between urban/rural and institutional action and reveals avenues for local government leadership in communities, research, student engagement and wider interactions.
    Keywords: Case study ; local government ; sustainable development ; local economic development ; women entrepreneurs ; Local Economic Development initiatives ; local government leadership ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics
    Language: English
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  • 2
    Publication Date: 2024-02-07
    Description: Omic BON is a thematic Biodiversity Observation Network under the Group on Earth Observations Biodiversity Observation Network (GEO BON), focused on coordinating the observation of biomolecules in organisms and the environment. Our founding partners include representatives from national, regional, and global observing systems; standards organizations; and data and sample management infrastructures. By coordinating observing strategies, methods, and data flows, Omic BON will facilitate the co-creation of a global omics meta-observatory to generate actionable knowledge. Here, we present key elements of Omic BON's founding charter and first activities.
    Type: Article , PeerReviewed
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  • 3
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    Oxford University Press
    Publication Date: 2024-04-01
    Description: "An Equal Burden forms the first scholarly study of the Army Medical Services in the First World War to focus on the roles and experiences of the men of the ranks of the Royal Army Medical Corps (RAMC). These men, through their work as stretcher bearers and orderlies, provided a range of labour, both physical and emotional, in aid of the sick and wounded. They were not professional medical caregivers, yet were called upon to provide medical care, however rudimentary; they served in uniform, under military discipline, yet were forbidden, as non-combatants, from carrying weapons. Their service as men in wartime, was thus unique. Structured both chronologically and thematically, this study examines both the work that RAMC rankers undertook and its importance to the running of the chain of medical evacuation. It additionally explores the gendered status of these men within the medical, military and cultural hierarchies of a society engaged in total war, locating their service within the context of that of doctors, female nurses and combatant servicemen. Through close readings of official documents, personal papers, and cultural representations, both verbal and visual, it argues that the ranks of the RAMC formed a space in which non-commissioned servicemen, through their many roles, defined and redefined medical caregiving as men’s work in wartime."
    Keywords: Royal Army Medical Corps ; First World War ; masculinity ; non-combatants ; military medicine ; care giving ; gender history ; cultural representation ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period) ; thema EDItEUR::M Medicine and Nursing
    Language: English
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  • 4
    Publication Date: 2024-04-06
    Description: This is the second book in the 'Health, Functioning and Technology' series. The focus of this book is on teaching, learning and assessment in rehabilitation education within the African context. The primary contributors to the book are authors from occupational therapy, physiotherapy and speech-language therapy in South Africa. The authors discuss local contextual drivers for renewing rehabilitation professions curricula that support graduates in becoming competent, socially accountable, and dynamic. The foundational element of the chapters in the book is the African context and evidence-informed educational practice. We include the impact of the COVID-19 pandemic on teaching, learning, student support and the integration of technology to assist in achieving the goals of the curricula. Through the different themes of transformative learning, curriculum renewal, technology for learning and clinical training key topics are covered on responsive curricula, leadership, interprofessional education, clinical competence, critical consciousness, peer teaching and learning, learning technologies, student support and emergency remote teaching and learning.
    Keywords: Curriculum reform;transformative learning;leadership;interprofessional education;clinical competence;peer teaching and learning;learning technologies ; thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQS Physiotherapy
    Language: English
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  • 5
    Publication Date: 2024-04-08
    Description: Science and Faith in Dialogue presents a cogent, compelling case for concordance between science and theism. The term theism refers, in this book, to the belief in God's existence. Within theology, the term theism is often used to convey a range of presuppositions about the nature and attributes of God. Based on scientific and natural theological perspectives, two pillars of natural theology are revisited: the Cosmological Argument and the Argument from Design. The book argues that modern science provides undeniable evidence and a scientific basis for these classical arguments to infer a rationally justifiable endorsement of theism as being concordant with reason and science – nature is seen as operating orderly on comprehensible, rational, consistent laws, in line with the conviction that God is Creator.
    Keywords: Faith ; science ; evolution ; intelligent design ; cosmology ; theism ; naturalism ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRC Christianity::HRCM Christian theology ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRV Aspects of religion::QRVG Theology
    Language: English
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  • 6
    Publication Date: 2023-02-08
    Description: Parasites are arguably among the strongest drivers of natural selection, constraining hosts to evolve resistance and tolerance mechanisms. Although, the genetic basis of adaptation to parasite infection has been widely studied, little is known about how epigenetic changes contribute to parasite resistance and eventually, adaptation. Here, we investigated the role of host DNA methylation modifications to respond to parasite infections. In a controlled infection experiment, we used the three-spined stickleback fish, a model species for host-parasite studies, and their nematode parasite Camallanus lacustris. We showed that the levels of DNA methylation are higher in infected fish. Results furthermore suggest correlations between DNA methylation and shifts in key fitness and immune traits between infected and control fish, including respiratory burst and functional trans-generational traits such as the concentration of motile sperm. We revealed that genes associated with metabolic, developmental and regulatory processes (cell death and apoptosis) were differentially methylated between infected and control fish. Interestingly, genes such as the neuropeptide FF receptor 2 and the integrin alpha 1 as well as molecular pathways including the Th1 and Th2 cell differentiation were hypermethylated in infected fish, suggesting parasite-mediated repression mechanisms of immune responses. Altogether, we demonstrate that parasite infection contributes to genome-wide DNA methylation modifications. Our study brings novel insights into the evolution of vertebrate immunity and suggests that epigenetic mechanisms are complementary to genetic responses against parasite-mediated selection.
    Type: Article , PeerReviewed
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  • 7
    Publication Date: 2023-02-08
    Description: The two toothed jaws of cichlid fishes provide textbook examples of convergent evolution. Tooth phenotypes such as enlarged molar-like teeth used to process hard-shelled molluscs have evolved numerous times independently during cichlid diversification. While the ecological benefit of molar-like teeth to crush prey is known, it is unclear whether the same molecular mechanisms underlie these convergent traits. To identify genes involved in the evolution and development of enlarged cichlid teeth, we performed RNA-seq on the serially homologous toothed oral and pharyngeal jaws as well as the fourth toothless gill arch of Astatoreochromis alluaudi. We identified 27 genes that are highly upregulated on both tooth-bearing jaws compared to the toothless gill arch. Most of these genes have never been reported to play a role in tooth formation. Two of these genes (unk, rpfA) are not found in other vertebrate genomes but are present in all cichlid genomes. They also cluster genomically with two other highly expressed tooth genes (odam, scpp5) that exhibit conserved expression during vertebrate odontogenesis. Unk and rpfA were confirmed via in situ hybridization to be expressed in developing teeth of Astatotilapia burtoni. We then examined expression of the cluster's four genes in six evolutionarily independent and phylogenetically disparate cichlid species pairs each with a large- and a small-toothed species. Odam and unk commonly and scpp5 and rpfA always showed higher expression in larger-toothed cichlid jaws. Convergent trophic adaptations across cichlid diversity are associated with the repeated developmental deployment of this genomic cluster containing conserved and novel cichlid-specific genes.
    Type: Article , PeerReviewed
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  • 8
    Publication Date: 2024-02-07
    Description: With over 18,000 species, the Acanthomorpha, or spiny-rayed fishes, form the largest and arguably most diverse radiation of vertebrates. One of the key novelties that contributed to their evolutionary success are the spiny rays in their fins that serve as a defense mechanism. We investigated the patterning mechanisms underlying the differentiation of median fin Anlagen into discrete spiny and soft rayed domains during the ontogeny of the direct-developing cichlid fish Astatotilapia burtoni. Distinct transcription factor signatures characterize these two fin domains, whereby mutually exclusive expression of hoxa13a/b with alx4a/b and tbx2b marks the spine to soft-ray boundary. The soft-ray domain is established by BMP inhibition via gremlin1b, which synergizes in the posterior fin with shh secreted from a zone of polarizing activity. Modulation of BMP signaling by chemical inhibition or gremlin1b CRISPR/Cas9 knockout induces homeotic transformations of spines into soft rays and vice versa. The expression of spine and soft-ray genes in nonacanthomorph fins indicates that a combination of exaptation and posterior expansion of an ancestral developmental program for the anterior fin margin allowed the evolution of robustly individuated spiny and soft-rayed domains. We propose that a repeated exaptation of such pattern might underly the convergent evolution of anterior spiny fin elements across fishes.
    Type: Article , PeerReviewed
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  • 9
  • 10
    Publication Date: 2021-10-06
    Print ISSN: 0002-7863
    Electronic ISSN: 1520-5126
    Topics: Chemistry and Pharmacology
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