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  • 2020-2024  (11,012)
  • 1945-1949  (12,942)
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  • 1
    Keywords: Water. ; Hydrology. ; Freshwater ecology. ; Marine ecology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Pollution. ; Refuse and refuse disposal. ; Water. ; Freshwater and Marine Ecology. ; Environmental Engineering/Biotechnology. ; Pollution. ; Waste Management/Waste Technology.
    Description / Table of Contents: Introduction -- Density -- Heat Capacity -- Entropy -- Latent Heat -- Boiling Point Elevation -- Vapor Pressure -- Viscosity -- Thermal Conductivity -- Activity Coefficient -- Osmotic Coefficient -- Surface Tension -- Electrical Conductivity -- Thermal Expansivity -- List of Nomenclature.
    Abstract: This book accommodates the existing correlations, data, and methods for thermodynamic and thermophysical properties of saline water, including multiple components at a wide range of salinity (reaching around 200 g/kg), temperature, and pressure. The correlations of each property are plotted against existing experimental data to judge the comparative accuracy of each within a given specific range of salinity, temperature, and pressure. An assessment to recommend some correlations is also conducted. New correlations for some properties are also proposed. This book helps to provide the saline water properties as needed for engineers, designers, and research for different areas, including desalination and water treatment. All the analytical analysis, thermodynamic analysis, and design models of the desalination technologies depend on saline water properties. As scientists and researchers working on different desalination technologies, the authors found it difficult to find all saline water properties in one source, including multicomponent and binary salty solutions, under different conditions (salinity, temperature, and pressure). Therefore, the authors introduce this book to fill the gap in the open literature. This book compiles the thermodynamic and thermophysical properties of saline water, involving thermodynamic approaches, multicomponent models, and simple correlations and data, comparison between the correlations of properties in figures, recommendation of the most accurate correlations and methods, and the used codes to estimate these correlations and methods. It is expected that this book to be a principal source for all interests in desalination and water treatment subjects.
    Type of Medium: Online Resource
    Pages: XIX, 325 p. 39 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031351938
    Series Statement: Springer Water,
    DDC: 551.48
    Language: English
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  • 2
    Keywords: Botany. ; Plant diseases. ; Fungi. ; Mycology. ; Microbiology. ; Plant biotechnology. ; Ecology . ; Plant Science. ; Plant Pathology. ; Fungi. ; Plant Biotechnology. ; Ecology.
    Description / Table of Contents: Chapter 1. Mycotoxins and Their Producers: Diversity, Side Effects and Control -- Chapter 2. Seed-Borne Mycoflora and Their Management -- Chapter 3. Rhizosphere Mycobiome: Roles, Diversity, and Dynamics -- Chapter 4. Phyllosphere Mycobiome: Diversity and Function -- Chapter 5. Plant Mycobiome in Sustainable Agriculture -- Chapter 6. Plant-Fungus Interactions in Rust Diseases -- Chapter 7. Rust Haustoria -- Chapter 8. Recent Advancement in Fungal Biocontrol Agents -- Chapter 9. New Perspectives on Fungal Siderophores -- Chapter 10. Biogenic Synthesis of Nanoparticles Mediated by Fungi -- Chapter 11. Plant Growth-Promoting Fungi for Growth Improvement and Resistance Induction -- Chapter 12. An Insight into Fungi in Forest Ecosystems -- Chapter 13. Recent Progress on Fungal Enzymes -- Chapter 14. Endophytic Fungi as Sources of Novel Natural Compounds -- Chapter 15. Symbiotic Relationships with Fungi: From Mutualism to Parasitism -- Chapter 15. Symbiotic Relationships with Fungi: From Mutualism to Parasitism -- Chapter 16. Roles and Benefits of Mycorrhiza -- Chapter 17. Mycorrhizal Networks: A Secret Interplant Communication System -- Chapter 18. Impacts of Climate Change on Plant Mycobiome. .
    Abstract: Plant mycobiome represents a diverse array of plant-associated communities of endophytic and epiphytic fungi. These communities fundamentally affect plant health, development, adaptation, and communication with the surrounding ecosystem. Furthermore, they have key roles in the establishment, diversification, productivity, and sustainability of different natural ecosystems. However, some of these communities are pathogenic for the plant itself or dangerous for the consumers, due to the production of mycotoxins. In other words, plant mycobiome represents two faces of a coin. This book aimed to explore contributions of the plant mycobiome in plant-environment interactions from different perspectives. Chapters of this book address numerous themes covering the recent advances in roles, diversity, and dynamics of these fungi as biocontrol agents, biofertilizers, growth promoters, and their secondary metabolites in the area of crop improvement for sustainability and biotechnology, as well as the plant pathogenic and toxigenic fungi. This book will be useful to postgraduate students, botanists, mycologists, ecologists, plant pathologists, and physiologists.
    Type of Medium: Online Resource
    Pages: XII, 496 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031283079
    DDC: 580
    Language: English
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  • 3
    Keywords: Biodiversity. ; Agriculture. ; Forestry. ; Plant biotechnology. ; Plant diseases. ; Energy policy. ; Energy and state. ; Biodiversity. ; Agriculture. ; Forestry. ; Plant Biotechnology. ; Plant Pathology. ; Energy Policy, Economics and Management.
    Description / Table of Contents: Genetically modified organisms (GMOs) impact and current status in Latin America: technological sovereignty or dependence? -- New biotechnology promising approaches for disease control on bananas and plantains -- Complementation of bananas conventional breeding programs through biotechnological genetic improvement -- The stress as inducer of heritable changes in micropropagated banana: the hypothesis of cytokinin accumulation -- Somatic embryogenesis for clonal propagation and associated molecular studies in cacao (Theobroma cacao L.) -- Use of biotechnology in Forestry breeding programs for natural resources and biodiversity conservation; Creating super trees for the future -- Stress modulation in Pinus spp. Somatic embryogenesis as model for climate change mitigation; Stress is not always a problem -- A Protective Role for Accumulated Dry Matter Reserves in Seeds During Desiccation: Implications for Conservation -- Biodiversity in Ecuador and its immense potential for agricultural pest control -- Native biodiversity: a strategic resource to accelerate bioeconomy development in Latin America and the Caribbean -- Low cost crop waste biosorbent technology for removing toxic and pollutants from wastewater -- The status of plant and plant-microbe interactions related to medicinal agents -- Bringing new function to packaging materials by agricultural byproducts -- Use of banana crop wastes to develop products in the aquaculture and plastic sectors -- Use of agroindustrial biomass for biofuels, enzymes discovery and production -- Temperature Profiles during the Fermentation of Cacao ‘Nacional’ to understand chocolate quality -- Ethno Phytopharmacology. Product validation process based on traditional knowledge of medicinal plants -- Biological control as a key tool for the management of invasive species in Latin America and the Caribbean -- Current research on Andean fruit crop diseases -- Biotechnological tools for the development of Foc TR4-resistant or tolerant Musa spp. Cultivars -- Integrated pest management of whitefly crop-free periods can reduce the Begomovirus transmission in tomato.
    Abstract: Food security, crop protection, biodiversity, and human and environmental health are among the main needs and concerns of society. Modern biotechnology and life sciences represent a constantly evolving area that is key for the rational use of natural resources – resources that in turn are indispensable for societal development. This book features the outcomes of the IV International Biotechnology and Biodiversity Congress, held in Guayaquil, Ecuador, 2018. It includes extensive reviews of the trends in agricultural and forestry biotechnology, molecules and materials biodiscovery, ethnomedicine, environmental impact and bioindustry research, describing many of these topics from the Latin America perspective and showing how the biodiversity and ancient knowledge of these countries are vital for worldwide sustainable development. .
    Type of Medium: Online Resource
    Pages: XIX, 460 p. 82 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030513580
    DDC: 333.95
    Language: English
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  • 4
    Keywords: Human physiology. ; Nanotechnology. ; Cancer. ; Nanochemistry. ; Bacteria. ; Human Physiology. ; Nanotechnology. ; Cancer Biology. ; Nanochemistry. ; Bacteria.
    Description / Table of Contents: Chapter 1. Research Progression on Studies Related to Green Synthesis Nanoparticles: A Bibliometric Review -- Chapter 2. Current Green Nanotechnology: The Case of Noble Metal Nanocomposites and Applications -- Chapter 3. Role of Solvent System in Green Synthesis of Nanoparticles -- Chapter 4. Surface Engineering Techniques Associated with Stability, Biocompatibility and Toxicity of Nanoparticles -- Chapter 5. Role of Light in the Improvement of Nanoparticles Synthesis -- Chapter 6. Application of Nanomaterials for Cancer Diagnosis and Therapy -- Chapter 7. Marine Resources for Biosynthesis and Surface Modification of Anticancer Nanoparticles -- Chapter 8. Green Synthesis of Nanoparticles and Their Application in Cancer Therapy -- Chapter 9. Gold Nanoparticles: Biogenic Synthesis and Anticancer Application -- Chapter 10. Toxicity and Synthesis of Bacteriogenic Silver Nanoparticles Against Bacterial Pathogens: A Critical Review -- Chapter 11. Green Synthesis of Selenium Nanoparticles (SeNPs) via Environment-Friendly Biological Entities -- Chapter 12. Biogenic Synthesis, Characterization, Toxicity Assessment, Antiparasitic and Antibacterial Activities of Silver Nanoparticle from Lippia Multiflora -- Chapter 13. Green Synthesis of MgO Nanoparticles and its Effect on Chlorophyll Content in Plant Tissue Culture -- Chapter 14. Application of Green Nano-silica in Civil Engineering. .
    Abstract: This book describes various strategies for the synthesis of green nanoparticles using plant extracts and microbes, including the advantages and disadvantages of different methods and their applications. After discussing strategies for and the potential of green synthesis of noble metal nanoparticles, it highlights the role of the solvent system. The book then explores the stability/toxicity of nanoparticles and the associated-surface engineering techniques for achieving biocompatibility, and examines the antimicrobial efficacy of green nanoparticles with regard to various bacterial pathogens, as well as the underlying cytotoxicity mechanisms. Lastly, the book addresses the potential applications of various green nanoparticles in cancer theranostics, and reviews a number of plant-mediated nanoparticles as potential pharmaceutical agents. Given its scope, the book will be of interest to all scientists and students wanting to learn more about the synthesis and applications of green nanoparticles.
    Type of Medium: Online Resource
    Pages: XV, 316 p. 78 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551796
    DDC: 612
    Language: English
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  • 5
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Veterinary medicine. ; Animal biotechnology. ; Nanobiotechnology. ; Veterinary Science. ; Animal Biotechnology. ; Nanobiotechnology.
    Description / Table of Contents: Chapter 1_Introduction -- Chapter 2_Application of ultrasonography in bovine reproduction -- Chapter 3_Infrared thermal imaging and its application in animal reproduction. -Chapter 4_Technological advancements for early pregnancy diagnosis in cattle and buffaloes -- Chapter 5_Bull sperm selection for assisted reproduction -- Chapter 6_Nano purification of semen: A novel technique for enrichment of superior quality spermatozoa. -Chapter 7_Sperm transcriptome sequencing for predicting bull Fertility-Concepts, facts and future directions -- Chapter 8_Semen proteomics and metabolomics: Emerging tools for discovering fertility markers -- Chapter 9_Spermatogonial stem cells: Their use in fertility restoration -- Chapter 10_Multiple Ovulation and Embryo Transfer in Livestock Production -- Chapter 11_Ovum pick-up and in vitro embryo production in bovine -- Chapter 12_Milestones and recent developments in farm animal cloning -- Chapter 13_Advances and applications of transgenesis in farm animals -- Chapter 14_Offspring sex pre-selection in mammals: An Update -- Chapter 15_Genomic selection of bovines for fertility -- Chapter 16_Prospects of Stem Cells in Fertility Management in Bovine -- Chapter 17_Conclusion.
    Abstract: This book details the frontier technologies in the area of bovine reproduction. It describes the importance and significance of different technologies for improving reproduction efficiency in bovines. The book delineates the advancements in the technologies that are currently in use for faster multiplication of elite germ plasm including multiple ovulation and embryo transfer, ovum-pick-up, in vitro fertilization and embryo production, and semen sexing. Other emerging technologies, having potential for improving reproductive efficiency in bovines, including stem cells are also discussed with special reference to spermatogonial stem cells. Simple but effective tools having a great scope for day-to-day application in bovine farms for effective reproductive management like ultrasonography and thermal imaging are also covered in this book. The chapters on sperm transcriptomics, proteomics, metabolomics provide current developments in these areas and use of integrated approach for identification of fertility biomarkers. The chapters also describe technological advancements for early pregnancy diagnosis and offspring sex pre-selection in bovines. Additionally, this book discusses different sperm selection procedures including application of nanotechnology to obtain superior spermatozoa for assisted reproduction. Futuristic technologies including genomic selection and transgenesis are also discussed in detail. Finally, the book also elucidates a comprehensive description of challenges perceived with bovine reproduction and how effectively these technologies can help in improving fertility in bovines.
    Type of Medium: Online Resource
    Pages: X, 341 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811930720
    DDC: 636.089
    Language: English
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  • 6
    Keywords: Pharmaceutical chemistry. ; Pharmacology. ; Clinical biochemistry. ; Pharmaceutics. ; Pharmacology. ; Medical Biochemistry.
    Description / Table of Contents: Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs -- Optimizing the Formulation of Poorly Water-Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle-Size Reduction Techniques -- Co-solvent and Complexation Systems -- Injectable Formulations of Poorly Water-Soluble Drugs -- Lipid-Based Formulations -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray-Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs -- Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
    Abstract: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. Highlights the most recent advancements reported in the literature on technologies to improve the dissolution and bioavailability of poorly water soluble drugs Provides a comprehensive discussion of new technologies developed and recently over 40% updated new content Essential read for scientists and researchers in pharmaceutical, chemical, and agricultural industries since over 80% of newly discovered drugs are poorly water soluble.
    Type of Medium: Online Resource
    Pages: XII, 693 p. 280 illus., 138 illus. in color. , online resource.
    Edition: 3rd ed. 2022.
    ISBN: 9783030887193
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 50
    DDC: 615.19
    Language: English
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  • 7
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Public health. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology. ; Public Health.
    Description / Table of Contents: Clinical features, diagnostic evaluation and management of COVID-19 patients -- Outbreak of COVID-19: A Detailed Overview and Its Consequences -- A paradigm gap in host-pathogen interaction studies: Lesson from the COVID-19 pandemic -- SARS/CoV-2: Behavioral Host Manipulation -- Management of COVID-19 in the Intensive Care Unit -- First wave of Covid-19 pandemic in Italy: data and evidence -- Risk factors for COVID-19: diabetes, hypertension and obesity -- Current challenges for the effective management of the COVID-19 pandemic -- COVID-19 Outbreak Challenges in Indian Migrant Pregnant and Lactating Mothers: Learnt Lesson Demands Phronesis and Hierarchical Strategies for Such Future Pandemics -- COVID-19 and Extracorporeal Membrane Oxygenation -- COVID-19's Clinical-Pathological Evidence in Relation to its Repercussion on the Central and Peripheral Nervous System -- Anatomopathological Aspects and Clinical Correlation of COVID-19: A Systematic Review -- SARS-CoV-2 liability: the hidden mystery behind its presentation in children.
    Abstract: The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 241 p. 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851132
    Series Statement: Advances in Experimental Medicine and Biology, 1353
    DDC: 610.72
    Language: English
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  • 8
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology.
    Description / Table of Contents: Origin and structural biology of Novel Coronavirus (SARS-CoV-2) -- The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2 -- Epidemiology, transmission and molecular immunopathology of SARS-CoV-2 -- Epidemiology and Etiopathogeny of Covid-19 -- Immunological and Hematological Response in COVID-19 -- Toll-like receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective -- Potential drug strategies to target Coronaviruses -- Possible therapeutic intervention strategies for COVID-19 by manipulating the cellular proteostasis network -- The potential impact of statins in the treatment of patients with COVID-19 infection -- Anticoronavirus activity of water-soluble pristine C60 fullerenes: in vitro and in silico screening -- Application of Nanoscale materials and nanotechnology against viral infection: A special focus on Coronaviruses -- Obesity: A Risk Factor for Covid-19 -- Cytokine Storm and Failed Resolution in COVID-19: Taking Cue from Multiple Sclerosis.
    Abstract: The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin, structural biology and molecular aspects of Coronaviruses. It also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 222 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851095
    Series Statement: Advances in Experimental Medicine and Biology, 1352
    DDC: 610.72
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology.
    Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.
    Abstract: The book Heat Shock Proteins in Human Diseases provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins (HSP) in various types of human diseases including cancer, cardiovascular disease, microbiology and inflammation. These diseases were specifically chosen due to their dismal prognosis, the survival benefit offered by the current standards do not greatly impact the overall survival statistics with the disease and are associated with toxicity. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in human diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 297 p. 31 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030622893
    Series Statement: Heat Shock Proteins, 21
    DDC: 610.72
    Language: English
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  • 10
    Keywords: Pharmacology. ; Medicinal chemistry. ; Pharmaceutical chemistry. ; Biotechnology. ; Biochemical engineering. ; Pharmacology. ; Medicinal Chemistry. ; Pharmaceutics. ; Biotechnology. ; Bioprocess Engineering.
    Description / Table of Contents: Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
    Abstract: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
    Type of Medium: Online Resource
    Pages: XI, 207 p. 174 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811923203
    Series Statement: Progress in Drug Research, 76
    DDC: 615
    Language: English
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