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  • Wiley  (3)
  • Nature Publishing Group  (2)
  • Molecular Diversity Preservation International  (1)
  • 2020-2024  (3)
  • 1960-1964  (2)
  • 1925-1929  (1)
Collection
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Parathyroid Hormone and Magnesium Homoeostasis (1963)
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 1058-1060 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SEVERAL groups of workers1-3 have claimed that parathyroid hormone reduces calcium excretion in the urine, although Gordan4 has shown that this is difficult to demonstrate in parathyroid disorders. The situation has been further complicated by the recent report of Widrow and Levinsky5 that, while ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1981058a0
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Antidiuretic Hormone and Renal Collecting Tubules (1961)
    [s.l.] : Nature Publishing Group
    Nature 192 (1961), S. 76-76 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fifty-two young male white rats, 150-200 gm. in weight, were fasted overnight with free access to water and then treated in one of four ways: (1) Eighteen rats were given water by stomach tube (5 per cent of body-weight followed by 3 per cent after 1 hr., or 7 per cent of body-weight with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/192076a0
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Summer Meeting of the Corn Belt Section (1926)
    Wiley
    Details
    Publication Date: 1926-09-01
    Print ISSN: 0002-1962
    Electronic ISSN: 1435-0645
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Wiley
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    PAPER CURRENT
  • 4
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    Three major mesoplanktonic communities resolved by in situ imaging in the upper 500 m of the global ocean (2023)
    Wiley
    Details
    Publication Date: 2024-02-07
    Description: Aim: The distribution of mesoplankton communities has been poorly studied at global scale, especially from in situ instruments. This study aims to (1) describe the global distribution of mesoplankton communities in relation to their environment and (2) assess the ability of various environmental-based ocean regionalizations to explain the distribution of these communities. Location: Global ocean, 0–500 m depth. Time Period: 2008–2019. Major Taxa Studied: Twenty-eight groups of large mesoplanktonic and macroplanktonic organisms, covering Metazoa, Rhizaria and Cyanobacteria. Methods: From a global data set of 2500 vertical profiles making use of the Underwater Vision Profiler 5 (UVP5), an in situ imaging instrument, we studied the global distribution of large (〉600 μm) mesoplanktonic organisms. Among the 6.8 million imaged objects, 330,000 were large zooplanktonic organisms and phytoplankton colonies, the rest consisting of marine snow particles. Multivariate ordination (PCA) and clustering were used to describe patterns in community composition, while comparison with existing regionalizations was performed with regression methods (RDA). Results: Within the observed size range, epipelagic plankton communities were Trichodesmium-enriched in the intertropical Atlantic, Copepoda-enriched at high latitudes and in upwelling areas, and Rhizaria-enriched in oligotrophic areas. In the mesopelagic layer, Copepoda-enriched communities were also found at high latitudes and in the Atlantic Ocean, while Rhizaria-enriched communities prevailed in the Peruvian upwelling system and a few mixed communities were found elsewhere. The comparison between the distribution of these communities and a set of existing regionalizations of the ocean suggested that the structure of plankton communities described above is mostly driven by basin-level environmental conditions. Main Conclusions: In both layers, three types of plankton communities emerged and seemed to be mostly driven by regional environmental conditions. This work sheds light on the role not only of metazoans, but also of unexpected large protists and cyanobacteria in structuring large mesoplankton communities.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
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    PAPER (OCEANREP)
  • 5
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    Modeling Structure–Activity Relationship of AMPK Activation (2021)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2021-10-28
    Description: The adenosine monophosphate activated protein kinase (AMPK) is critical in the regulation of important cellular functions such as lipid, glucose, and protein metabolism; mitochondrial biogenesis and autophagy; and cellular growth. In many diseases—such as metabolic syndrome, obesity, diabetes, and also cancer—activation of AMPK is beneficial. Therefore, there is growing interest in AMPK activators that act either by direct action on the enzyme itself or by indirect activation of upstream regulators. Many natural compounds have been described that activate AMPK indirectly. These compounds are usually contained in mixtures with a variety of structurally different other compounds, which in turn can also alter the activity of AMPK via one or more pathways. For these compounds, experiments are complicated, since the required pure substances are often not yet isolated and/or therefore not sufficiently available. Therefore, our goal was to develop a screening tool that could handle the profound heterogeneity in activation pathways of the AMPK. Since machine learning algorithms can model complex (unknown) relationships and patterns, some of these methods (random forest, support vector machines, stochastic gradient boosting, logistic regression, and deep neural network) were applied and validated using a database, comprising of 904 activating and 799 neutral or inhibiting compounds identified by extensive PubMed literature search and PubChem Bioassay database. All models showed unexpectedly high classification accuracy in training, but more importantly in predicting the unseen test data. These models are therefore suitable tools for rapid in silico screening of established substances or multicomponent mixtures and can be used to identify compounds of interest for further testing.
    Electronic ISSN: 1420-3049
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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    PAPER CURRENT
  • 6
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    Three major mesoplanktonic communities resolved by in situ imaging in the upper 500 m of the global ocean (2023)
    Wiley
    In:  EPIC3Global Ecology and Biogeography, Wiley, ISSN: 1466-822X
    Details
    Publication Date: 2023-08-08
    Description: Aim: The distribution of mesoplankton communities has been poorly studied at global scale, especially from in situ instruments. This study aims to (1) describe the global distribution of mesoplankton communities in relation to their environment and (2) as-sess the ability of various environmental- based ocean regionalizations to explain the distribution of these communities. Location: Global ocean, 0–500 m depth. Time Period: 2008–2019. Major Taxa Studied: Twenty-eight groups of large mesoplanktonic and macroplank-tonic organisms, covering Metazoa, Rhizaria and Cyanobacteria. Methods: From a global data set of 2500 vertical profiles making use of the Underwater Vision Profiler 5 (UVP5), an in situ imaging instrument, we studied the global distribu-tion of large (〉600 μm) mesoplanktonic organisms. Among the 6.8 million imaged ob-jects, 330,000 were large zooplanktonic organisms and phytoplankton colonies, the rest consisting of marine snow particles. Multivariate ordination (PCA) and clustering were used to describe patterns in community composition, while comparison with existing regionalizations was performed with regression methods (RDA). Results: Within the observed size range, epipelagic plankton communities were Trichodesmium- enriched in the intertropical Atlantic, Copepoda- enriched at high latitudes and in upwelling areas, and Rhizaria-enriched in oligotrophic areas. In the mesopelagic layer, Copepoda-enriched communities were also found at high lati-tudes and in the Atlantic Ocean, while Rhizaria-enriched communities prevailed in the Peruvian upwelling system and a few mixed communities were found elsewhere. The comparison between the distribution of these communities and a set of existing regionalizations of the ocean suggested that the structure of plankton communities described above is mostly driven by basin- level environmental conditions. Main Conclusions: In both layers, three types of plankton communities emerged and seemed to be mostly driven by regional environmental conditions. This work sheds light on the role not only of metazoans, but also of unexpected large protists and cy-anobacteria in structuring large mesoplankton communities.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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    PAPER (OA)
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