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  • 2020-2024  (42)
  • 1980-1984  (210)
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  • 1
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Abstract: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Type of Medium: Online Resource
    Pages: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031039942
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 183
    DDC: 610.72
    Language: English
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  • 2
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression -- Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening -- Ion channels in Lung Cancer -- Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer -- Transportome Malfunctions and the Hallmarks of Pancreatic Cancer -- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer -- Ion Channels in Glioma Malignancy -- Membrane Transporters and Channels in Melanoma -- Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
    Abstract: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, and Ahmed Ahidouch Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening Valerio Farfariello, Natalia Prevarskaya, and Dimitra Gkika Ion Channels in Lung Cancer Etmar Bulk, Luca Matteo Todesca, and Albrecht Schwab Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer Giuliano Ciarimboli, Gerit Theil, Joanna Bialek, and Bayram Edemir Transportome Malfunctions and the Hallmarks of Pancreatic Cancer Qi Ling and Holger Kalthoff How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer Christian Stock Ion Channels in Glioma Malignancy Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, and Fabio Franciolini Membrane Transporters and Channels in Melanoma Ines Böhme, Roland Schönherr, Jürgen Eberle, and Anja Katrin Bosserhoff Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application Nagore Del-Río-Ibisate, Rocío Granda-Díaz, Juan P. Rodrigo, Sofía T. Menéndez, and Juana M. García-Pedrero.
    Type of Medium: Online Resource
    Pages: IX, 427 p. 50 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030909208
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 181
    DDC: 610.72
    Language: English
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  • 3
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Physiology.
    Description / Table of Contents: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.
    Abstract: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression Line O. Elingaard-Larsen, Michala G. Rolver, Ester E. Sørensen, and Stine F. Pedersen Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression Ebbe Boedtkjer Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer Larry Fliegel Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, and Alessandra Fiorio Pla Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? Christian Stock.
    Type of Medium: Online Resource
    Pages: XV, 175 p. 40 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030998004
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 182
    DDC: 610.72
    Language: English
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  • 4
    Call number: PIK W 100-22-94745
    Description / Table of Contents: The 'good farmer': cultural dimensions of farming and social change -- The origins of the 'good farmer' -- How symbols of 'good farming' develop: the historical development of 'tidy farming' -- Theorising the 'good farmer': from common sense category to analytical construct -- Morality and the 'good farmer' -- The gendered 'good farmer' -- The 'good farmer' in communities of practice -- Future challenges for the 'good farmer'.
    Description / Table of Contents: "Developed by the leading authors in the field, this book provides a cohesive and definitive theorisation of the concept of the 'good farmer', addressing the blind spots that have sprung up in agri-food literature as well as providing a springboard for future research. The concept of the good farmer has emerged in recent years as part of a move away from attitude and economics based understandings of farm decision-making towards a deeper understanding of culture and symbolism in agriculture. The Good Farmer shows why agricultural production is socially and culturally, as well as economically, important. It explores the history of the concept and its position in contemporary theory, as well as its use and meaning in a variety of different contexts, including landscape, environment, gender, society, and as a tool for resistance. By exploring the idea of the good farmer, it reveals the often-unforeseen assumptions implicit in food and agricultural policy that draw on culture, identity, and presumed notions of what is good. Finally, the book looks at the potential of the good farmer concept for addressing future, emerging issues in agriculture. This book will be of interest to students and scholars of food and agriculture and rural development, as well and professionals and policymakers involved in the food and agricultural industry"
    Type of Medium: Monograph available for loan
    Pages: xi, 184 Seiten , Illustrationen
    ISBN: 978-1-138-72796-0
    Series Statement: Earthscan food and agriculture series
    Language: English
    Branch Library: PIK Library
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  • 5
    Publication Date: 2021-10-20
    Description: Environmental stimuli attack the skin daily resulting in the generation of reactive oxygen species (ROS) and inflammation. One pathway that regulates oxidative stress in skin involves Protein Phosphatase 2A (PP2A), a phosphatase which has been previously linked to Alzheimer’s Disease and aging. Oxidative stress decreases PP2A methylation in normal human dermal fibroblasts (NHDFs). Thus, we hypothesize agents that increase PP2A methylation and activity will promote skin health and combat aging. To discover novel inhibitors of PP2A demethylation activity, we screened a library of 32 natural botanical extracts. We discovered Grape Seed Extract (GSE), which has previously been reported to have several benefits for skin, to be the most potent PP2A demethylating extract. Via several fractionation and extraction steps we developed a novel grape seed extract called Activated Grape Seed Extract (AGSE), which is enriched for PP2A activating flavonoids that increase potency in preventing PP2A demethylation when compared to commercial GSE. We then determined that 1% AGSE and 1% commercial GSE exhibit distinct gene expression profiles when topically applied to a 3D human skin model. To begin to characterize AGSE’s activity, we investigated its antioxidant potential and demonstrate it reduces ROS levels in NHDFs and cell-free assays equal to or better than Vitamin C and E. Moreover, AGSE shows anti-inflammatory properties, dose-dependently inhibiting UVA, UVB and chemical-induced inflammation. These results demonstrate AGSE is a novel, multi-functional extract that modulates methylation levels of PP2A and supports the hypothesis of PP2A as a master regulator for oxidative stress signaling and aging in skin.
    Electronic ISSN: 1420-3049
    Topics: Chemistry and Pharmacology
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  • 6
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    Bristol University Press
    Publication Date: 2022-03-30
    Description: ePDF and ePUB available Open Access under CC-BY-NC-ND licence. This book is concerned with the effects of migration policy making in Europe on migrants in the Global South and links insights on immobility to social theories of time to examine the human consequences of current migration dynamics from the perspectives of migrants themselves. Based on in-depth ethnographic research, this is an invaluable learning resource that aims to challenge current international migration politics and policy-making.
    Keywords: EU migration policy; Immobility; Migration; Morocco; Social theories of time ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFD Refugees & political asylum ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFM Social mobility ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFN Migration, immigration & emigration
    Language: English
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  • 7
    Publication Date: 2024-03-22
    Description: Gesellschaftliche, politische und wissenschaftliche Forderungen nach mehr Beteiligung, Zugang und Mitwirkung sind ebenso allgegenwärtig wie spannungsgeladen und durchzogen von Ambivalenzen. Mediale Teilhabe fragt nach den medialen Ermöglichungs- und Austauschprozessen, als deren Effekt Teilhabe/Nicht-Teilhabe entsteht. Entlang der Modalitäten Verschalten, Temporalisieren und Teilhabende Kritik entwickeln die Beiträge einen differenzierten Blick auf Teilhabe im Spannungsfeld von Anspruch und Inanspruchnahme.
    Keywords: P87-96 ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFD Media studies ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy
    Language: German
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  • 8
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    transcript Verlag
    Publication Date: 2024-03-28
    Description: The first fundamental analysis of a cinematic testimony of the cultural decolonization processes between Mozambique and Portugal.
    Description: Wie wird koloniale Gewalt historisch thematisiert? Wie gehen dokumentarische Filme und geschichtspolitische Diskurse mit ihr um? Robert Stock nähert sich diesen Fragen mit kritischem Blick auf den Kolonialkrieg Portugals in Afrika und den nationalen Befreiungskampf Mosambiks. Dabei fokussiert er seine Untersuchung auf die Gestaltung, Funktion und Reflexion historischer Zeugenschaft. Am Material von bislang wenig beachteten Filmproduktionen über die Dekolonisierungsprozesse zwischen Mosambik und Portugal seit den 1970er Jahren analysiert er die sich verändernden Deutungsweisen der kolonialen Vergangenheit.
    Keywords: Testimony ; Decolonization ; Colonial War ; Struggle For Independence ; Documentary Film ; Mozambique ; Portugal ; Struggle For Liberation ; Film ; Postcolonialism ; Memory Culture ; Violence ; Media Studies ; Zeugenschaft ; Dekolonisierung ; Kolonialkrieg ; Unabhängigkeitskampf ; Dokumentarfilm ; Mosambik ; Befreiungskampf ; Postkolonialismus ; Erinnerungskultur ; Gewalt ; Medienwissenschaft ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies
    Language: German
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  • 9
    Publication Date: 2024-03-23
    Description: Earthquake early warning (EEW) for Aotearoa New Zealand is in its infancy. Establishing a public EEW system in New Zealand that can warn the general population comes with several reservations as there are many technological, societal, and cultural challenges to overcome. Even with recent technological advances, a successful EEW system will rely on people to react appropriately to the alerts and follow protective action recommendations, such as Drop, Cover, and Hold. Designing an EEW system requires a multidisciplinary approach that involves multiple stakeholders, including the public. This chapter introduces an overarching design science approach in investigating the feasibility of an EEW solution for New Zealand. It includes a participatory design method used for eight community workshops to understand people’s views on EEW. The workshop participants envisaged an EEW system for New Zealand that considers the intersections between services and technology, communication, and human behavior. They expected a holistic EEW system to incorporate public engagement, transparency, and inclusion. The design-led approach described in this chapter puts people at the center, encouraging a close engagement with communities to inform the development of relevant and trusted technological solutions. The robust engagement processes provide insights relevant to designing an EEW system for New Zealand.
    Keywords: Alpine Fault, Aotearoa, CARE package, DRM, EEW, Mexico City, NGO, NHC, New Zealand, The Bahamas, participatory design, pictogram, risk, signs, visual standards, wildfire, fire, flood, global warming, government, high-rise buildings, hurricane, hydrographs, industrial design, maps, opioid overdose ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration::AKP Product design ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSW Emergency services
    Language: English
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  • 10
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    Collège de France
    Publication Date: 2022-01-31
    Description: L’étroitesse d’esprit, le dogmatisme, l’intolérance, le fanatisme sont, à des degrés divers, des formes d’enfermement dans un schéma mental. Pour y échapper, il faut accéder à la « pluralité interprétative » : devenir capable de « manipuler » ses propres représentations et ses idées pour adopter, au moins temporairement et en imagination, d’autres points de vue que le sien. Mais quelles sont les bases cérébrales et mentales d’une telle capacité chez l’enfant et chez l’adulte ? À travers quell...
    Keywords: dispute de Qaraqorum ; développement de l’enfant ; Clausewitz ; simulation ; Robespierre ; relativisme ; point de vue ; traduction ; théorie de l’esprit ; cerveau ; histoire littéraire ; perspective ; stratégie cognitive ; Parménide ; rhétorique ; droits de l’enfant ; manipulation ; empathie ; espace ; Khipus ; inhibition ; religion ; dialogues ; Stendhal ; référentiels spatiaux ; herméneutique ; interprétation ; procès ; adolescent
    Language: French
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