ISSN:
1573-3904
Schlagwort(e):
Cyclic peptides
;
Cytotoxicity
;
NMR spectroscopy
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract Phakellistatins 2 and 4 are cyclic peptides with cancer cell growth inhibitory properties isolated from the ocean marine sponges Phakellia carteri and Phakellia costata. To verify the proposed structures of natural phakellistatins 2 and 4, the given sequential structures were synthesized and their NMR spectra compared with the natural product. A completely different spectral pattern indicates that the structure of the natural compound should be different in both cases. The synthetic compounds according to the formula of phakellistatin 2 and 4 turned out to be inactive against several human cancer cell lines.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1008869515556
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