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  • Oxford University Press  (246)
  • Copernicus  (97)
  • Nature Publishing Group
  • 2020-2024  (7)
  • 2010-2014  (339)
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  • 1
    Publication Date: 2012-10-17
    Description: In 2003 sediment core Lz1024 was drilled at Lake El'gygytgyn, far east Russian Arctic, in an area of the Northern Hemisphere which has not been glaciated for the last 3.6 Ma. Biogenic silica was used for analysing the oxygen isotope composition (δ18Odiatom) in the upper 13 m long section dating back about 250 ka with samples dominated by one taxa in the
    Print ISSN: 1814-9324
    Electronic ISSN: 1814-9332
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 2
    Publication Date: 2012-04-11
    Description: In 2003 sediment core Lz1024 was drilled at Lake El'gygytgyn, far east Russian Arctic, in an area of the Northern Hemisphere which has not been glaciated for the last 3.6 Ma. Biogenic silica was used for analysing the oxygen isotope composition (δ18Odiatom) in the upper 13 m long section dating back about 250 ka with samples dominated by one taxa in the
    Print ISSN: 1814-9340
    Electronic ISSN: 1814-9359
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 3
    Publication Date: 2024-02-07
    Description: Omic BON is a thematic Biodiversity Observation Network under the Group on Earth Observations Biodiversity Observation Network (GEO BON), focused on coordinating the observation of biomolecules in organisms and the environment. Our founding partners include representatives from national, regional, and global observing systems; standards organizations; and data and sample management infrastructures. By coordinating observing strategies, methods, and data flows, Omic BON will facilitate the co-creation of a global omics meta-observatory to generate actionable knowledge. Here, we present key elements of Omic BON's founding charter and first activities.
    Type: Article , PeerReviewed
    Format: text
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  • 4
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    Oxford University Press
    Publication Date: 2024-04-01
    Description: "An Equal Burden forms the first scholarly study of the Army Medical Services in the First World War to focus on the roles and experiences of the men of the ranks of the Royal Army Medical Corps (RAMC). These men, through their work as stretcher bearers and orderlies, provided a range of labour, both physical and emotional, in aid of the sick and wounded. They were not professional medical caregivers, yet were called upon to provide medical care, however rudimentary; they served in uniform, under military discipline, yet were forbidden, as non-combatants, from carrying weapons. Their service as men in wartime, was thus unique. Structured both chronologically and thematically, this study examines both the work that RAMC rankers undertook and its importance to the running of the chain of medical evacuation. It additionally explores the gendered status of these men within the medical, military and cultural hierarchies of a society engaged in total war, locating their service within the context of that of doctors, female nurses and combatant servicemen. Through close readings of official documents, personal papers, and cultural representations, both verbal and visual, it argues that the ranks of the RAMC formed a space in which non-commissioned servicemen, through their many roles, defined and redefined medical caregiving as men’s work in wartime."
    Keywords: Royal Army Medical Corps ; First World War ; masculinity ; non-combatants ; military medicine ; care giving ; gender history ; cultural representation ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period) ; thema EDItEUR::M Medicine and Nursing
    Language: English
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  • 5
    Publication Date: 2013-06-06
    Description: : INstruct is a database of high-quality, 3D, structurally resolved protein interactome networks in human and six model organisms. INstruct combines the scale of available high-quality binary protein interaction data with the specificity of atomic-resolution structural information derived from co-crystal evidence using a tested interaction interface inference method. Its web interface is designed to allow for flexible search based on standard and organism-specific protein and gene-naming conventions, visualization of protein architecture highlighting interaction interfaces and viewing and downloading custom 3D structurally resolved interactome datasets. Availability: INstruct is freely available on the web at http://instruct.yulab.org with all major browsers supported. Contact: haiyuan.yu@cornell.edu Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 6
    Publication Date: 2013-04-02
    Description: In Escherichia coli , 12 distinct RNA structures within the transcripts encoding ribosomal proteins interact with specific ribosomal proteins to allow autogenous regulation of expression from large multi-gene operons, thus coordinating ribosomal protein biosynthesis across multiple operons. However, these RNA structures are typically not represented in the RNA Families Database or annotated in genomic sequences databases, and their phylogenetic distribution is largely unknown. To investigate the extent to which these RNA structures are conserved across eubacterial phyla, we created multiple sequence alignments representing 10 of these messenger RNA (mRNA) structures in E. coli . We find that while three RNA structures are widely distributed across many phyla of bacteria, seven of the RNAs are narrowly distributed to a few orders of Gammaproteobacteria. To experimentally validate our computational predictions, we biochemically confirmed dual L1-binding sites identified in many Firmicute species. This work reveals that RNA-based regulation of ribosomal protein biosynthesis is used in nearly all eubacterial phyla, but the specific RNA structures that regulate ribosomal protein biosynthesis in E. coli are narrowly distributed. These results highlight the limits of our knowledge regarding ribosomal protein biosynthesis regulation outside of E. coli, and the potential for alternative RNA structures responsible for regulating ribosomal proteins in other eubacteria.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 7
    Publication Date: 2014-11-07
    Description: Microphthalmia-associated transcription factor ( MITF ) is a master regulator of pigmented cell survival and differentiation with direct transcriptional links to cell cycle, apoptosis and pigmentation. In mouse, Mitf is expressed early and uniformly in optic vesicle (OV) cells as they evaginate from the developing neural tube, and null Mitf mutations result in microphthalmia and pigmentation defects. However, homozygous mutations in MITF have not been identified in humans; therefore, little is known about its role in human retinogenesis. We used a human embryonic stem cell (hESC) model that recapitulates numerous aspects of retinal development, including OV specification and formation of retinal pigment epithelium (RPE) and neural retina progenitor cells (NRPCs), to investigate the earliest roles of MITF. During hESC differentiation toward a retinal lineage, a subset of MITF isoforms was expressed in a sequence and tissue distribution similar to that observed in mice. In addition, we found that promoters for the MITF-A , -D and -H isoforms were directly targeted by Visual Systems Homeobox 2 (VSX2), a transcription factor involved in patterning the OV toward a NRPC fate. We then manipulated MITF RNA and protein levels at early developmental stages and observed decreased expression of eye field transcription factors, reduced early OV cell proliferation and disrupted RPE maturation. This work provides a foundation for investigating MITF and other highly complex, multi-purposed transcription factors in a dynamic human developmental model system.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 8
    Publication Date: 2011-05-20
    Description: SUMMARY We present forward and adjoint spectral-element simulations of coupled acoustic and (an)elastic seismic wave propagation on fully unstructured hexahedral meshes. Simulations benefit from recent advances in hexahedral meshing, load balancing and software optimization. Meshing may be accomplished using a mesh generation tool kit such as CUBIT, and load balancing is facilitated by graph partitioning based on the SCOTCH library. Coupling between fluid and solid regions is incorporated in a straightforward fashion using domain decomposition. Topography, bathymetry and Moho undulations may be readily included in the mesh, and physical dispersion and attenuation associated with anelasticity are accounted for using a series of standard linear solids. Finite-frequency Fréchet derivatives are calculated using adjoint methods in both fluid and solid domains. The software is benchmarked for a layercake model. We present various examples of fully unstructured meshes, snapshots of wavefields and finite-frequency kernels generated by Version 2.0 ‘Sesame’ of our widely used open source spectral-element package SPECFEM3D.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 9
    Publication Date: 2012-02-22
    Description: SUMMARY The Central Iran plateau appears aseismic during the last few millenniums based on instrumental and historical seismic records. Nevertheless, it is sliced by several strike-slip faults that are hundreds of kilometres long. These faults display along-strike, horizontal offsets of intermittent gullies that suggest the occurrence of earthquakes in the Holocene. Establishing this is crucial for accurately assessing the regional seismic hazard. The first palaeoseismic study performed on the 200-km long, NS striking Anar fault shows that this right-lateral fault hosted three large ( M w ≈ 7) earthquakes during the Holocene or possibly Uppermost Pleistocene for the older one. These three seismic events are recorded within a sedimentary succession, which is not older than 15 ka, suggesting an average recurrence of at most 5 ka. The six optically stimulated luminescence ages available provide additional constraints and allow estimating that the three earthquakes have occurred within the following time intervals: 4.4 ± 0.8, 6.8 ± 1 and 9.8 ± 2 ka. The preferred age of the more recent event, ranging between 3600 and 5200 yr, suggests that the fault is approaching the end of its seismic cycle and the city of Anar could be under the threat of a destructive earthquake in the near future. In addition, our results confirm a previous minimum slip rate estimate of 0.8 ± 0.1 mm yr −1 for the Anar fault indicating that the westernmost prominent right-lateral faults of the Central Iran plateau are characterized by slip rates close to 1 mm yr −1 . These faults, which have repeatedly produced destructive earthquakes with large magnitudes and long recurrence interval of several thousands of years during the Holocene, show that the Central Iran plateau does not behave totally as a rigid block and that its moderate internal deformation is nonetheless responsible for a significant seismic hazard.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 10
    Publication Date: 2012-12-20
    Description: The University of California Santa Cruz (UCSC) Genome Browser ( http://genome.ucsc.edu ) offers online public access to a growing database of genomic sequence and annotations for a wide variety of organisms. The Browser is an integrated tool set for visualizing, comparing, analysing and sharing both publicly available and user-generated genomic datasets. As of September 2012, genomic sequence and a basic set of annotation ‘tracks’ are provided for 63 organisms, including 26 mammals, 13 non-mammal vertebrates, 3 invertebrate deuterostomes, 13 insects, 6 worms, yeast and sea hare. In the past year 19 new genome assemblies have been added, and we anticipate releasing another 28 in early 2013. Further, a large number of annotation tracks have been either added, updated by contributors or remapped to the latest human reference genome. Among these are an updated UCSC Genes track for human and mouse assemblies. We have also introduced several features to improve usability, including new navigation menus. This article provides an update to the UCSC Genome Browser database, which has been previously featured in the Database issue of this journal.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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