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  • Springer Nature  (258)
  • Oxford University Press  (246)
  • Blackwell Publishing Ltd
  • Nature Publishing Group
  • Wiley-Blackwell
  • 2020-2024  (14)
  • 2010-2014  (493)
Collection
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  • 1
    Publication Date: 2013-06-09
    Description: Article The murine G protein-coupled receptor 83 (Gpr83) is expressed widely in the brain, but its physiological role is largely unknown. Here Müller et al. show that Gpr83 regulates systemic energy metabolism in part by modulating ghrelin signalling in the arcuate nucleus of the hypothalamus. Nature Communications 4 doi: 10.1038/ncomms2968
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
  • 3
    Publication Date: 2024-02-07
    Description: Omic BON is a thematic Biodiversity Observation Network under the Group on Earth Observations Biodiversity Observation Network (GEO BON), focused on coordinating the observation of biomolecules in organisms and the environment. Our founding partners include representatives from national, regional, and global observing systems; standards organizations; and data and sample management infrastructures. By coordinating observing strategies, methods, and data flows, Omic BON will facilitate the co-creation of a global omics meta-observatory to generate actionable knowledge. Here, we present key elements of Omic BON's founding charter and first activities.
    Type: Article , PeerReviewed
    Format: text
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  • 4
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    Oxford University Press
    Publication Date: 2024-04-01
    Description: "An Equal Burden forms the first scholarly study of the Army Medical Services in the First World War to focus on the roles and experiences of the men of the ranks of the Royal Army Medical Corps (RAMC). These men, through their work as stretcher bearers and orderlies, provided a range of labour, both physical and emotional, in aid of the sick and wounded. They were not professional medical caregivers, yet were called upon to provide medical care, however rudimentary; they served in uniform, under military discipline, yet were forbidden, as non-combatants, from carrying weapons. Their service as men in wartime, was thus unique. Structured both chronologically and thematically, this study examines both the work that RAMC rankers undertook and its importance to the running of the chain of medical evacuation. It additionally explores the gendered status of these men within the medical, military and cultural hierarchies of a society engaged in total war, locating their service within the context of that of doctors, female nurses and combatant servicemen. Through close readings of official documents, personal papers, and cultural representations, both verbal and visual, it argues that the ranks of the RAMC formed a space in which non-commissioned servicemen, through their many roles, defined and redefined medical caregiving as men’s work in wartime."
    Keywords: Royal Army Medical Corps ; First World War ; masculinity ; non-combatants ; military medicine ; care giving ; gender history ; cultural representation ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period) ; thema EDItEUR::M Medicine and Nursing
    Language: English
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  • 5
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    Springer Nature | Springer
    Publication Date: 2024-03-29
    Description: This open access book aims to show which factors have been decisive in the rise of successful countries. Never before have so many people been so well off. However, prosperity is not a law of nature; it has to be worked for. A liberal economy stands at the forefront of this success – not as a political system, but as a set of economic rules promoting competition, which in turn leads to innovation, research and enormous productivity. Sustainable prosperity is built on a foundation of freedom, equal opportunity and a functioning government. This requires a stable democracy that cannot be defeated by an autocrat. Autocrats claim that “illiberalism” is more efficient, an assertion that justifies their own power. Although autocrats can efficiently guide the first steps out of poverty, once a certain level of prosperity has been achieved, people begin to demand a sense of well-being – freedom and codetermination. Only when this is possible will they feel comfortable, and progress will continue. Respect for human rights is crucial. The rules of the free market do not lean to either the right or left politically. Liberalism and the welfare state are not mutually exclusive. The “conflict” concerns the amount of government intervention. Should there be more or less? As a lawyer, entrepreneur, and board member with over 40 years of experience in this field of conflict, the author clearly describes the conditions necessary for a country to maintain its position at the top.
    Keywords: Comparative Politics ; Political Theory ; International Economics ; Governance and Government ; Liberalism ; Equal opportunity ; Stable democracy ; Freedom ; Free market ; Government intervention ; Liberal Economy ; Illiberalism ; Human rights ; Autocracy ; Poverty ; Prosperity ; Productivity ; Innovation ; Welfare state ; European Union ; Switzerland ; Immigration ; Integration ; Open access ; Comparative politics ; Political science & theory ; International economics ; Political structure & processes ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCL International economics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPH Political structure and processes
    Language: English
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  • 6
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    Springer Nature | Landscapes of the First World War
    Publication Date: 2024-04-04
    Description: For First World War stretcher bearers, wartime landscapes had a direct impact on the work they undertook. Trenches, shell holes, mud and sand all presented challenges to their ability to carry wounded men swiftly and safely from where they were injured to aid posts and beyond. At the same time, landmarks could assist bearers in navigating the landscape they worked in, enabling these men to develop particular skills in direction-finding. This chapter uses the diaries and memoirs of British stretcher bearers to examine experiences of carrying in a range of wartime landscapes. In exploring how different landscapes shaped the labour that bearers undertook and the physical and embodied nature of the bearer’s relationship with the landscape, it interrogates the masculine status of these men as non-combatant servicemen to uncover some of the relationship between landscape and masculine service identity in wartime.
    Keywords: first world war; landscapes; British stretcher bearers; masculine service identity ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period)
    Language: English
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  • 7
    Publication Date: 2024-03-29
    Description: This open access book brings together leading international violence researchers to examine the impact of the coronavirus pandemic on experiences of, and responses to, domestic and family violence. In April 2020 the United Nations predicted that for every three months the COVID-19 lockdowns continued an additional 15 million cases of domestic violence would occur worldwide, termed the "shadow pandemic". Drawing on empirical work situated within an international context, this book presents evidence alongside country specific case studies to provide a global exploration of how women’s insecurity increased during this global health crisis at the same as their access to support services reduced. It provides a timely analysis of the degree to which the pandemic and associated government restrictions impacted on women’s experiences of violence with particular attention to changes in its prevalence and severity, and in system and service responses to women’s help-seeking. In addition, the differential impacts of the pandemic in relation to the experiences of priority cohorts, including violence experienced by children and temporary migrant women is also explored. The key focus is on the nature, extent, and responses to the COVID-19 pandemic on service delivery, accessibility of support, and access to justice for women experiencing domestic and family violence.
    Keywords: gender-based violence ; family violence ; victims ; safety planning ; intimate partner violence ; gender and crime ; violence and risk ; social work ; community safety ; crime prevention ; domestic violence ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKV Crime & criminology ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKS Social welfare & social services::JKSN Social work ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSN Social work ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
    Language: English
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  • 8
    Publication Date: 2013-09-19
    Description: Article FGFR2 gene variation is associated with breast cancer risk but the molecular mechanism is unknown. Fletcher et al . provide a link between FGFR2 signalling and breast cancer susceptibility by demonstrating that FGFR2 signalling activates the ERa transcriptional network, which drives transcription of risk genes. Nature Communications doi: 10.1038/ncomms3464 Authors: Michael N. C. Fletcher, Mauro A. A. Castro, Xin Wang, Ines de Santiago, Martin O’Reilly, Suet-Feung Chin, Oscar M. Rueda, Carlos Caldas, Bruce A. J. Ponder, Florian Markowetz, Kerstin B. Meyer
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 9
    Publication Date: 2013-06-06
    Description: : INstruct is a database of high-quality, 3D, structurally resolved protein interactome networks in human and six model organisms. INstruct combines the scale of available high-quality binary protein interaction data with the specificity of atomic-resolution structural information derived from co-crystal evidence using a tested interaction interface inference method. Its web interface is designed to allow for flexible search based on standard and organism-specific protein and gene-naming conventions, visualization of protein architecture highlighting interaction interfaces and viewing and downloading custom 3D structurally resolved interactome datasets. Availability: INstruct is freely available on the web at http://instruct.yulab.org with all major browsers supported. Contact: haiyuan.yu@cornell.edu Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 10
    Publication Date: 2013-04-02
    Description: In Escherichia coli , 12 distinct RNA structures within the transcripts encoding ribosomal proteins interact with specific ribosomal proteins to allow autogenous regulation of expression from large multi-gene operons, thus coordinating ribosomal protein biosynthesis across multiple operons. However, these RNA structures are typically not represented in the RNA Families Database or annotated in genomic sequences databases, and their phylogenetic distribution is largely unknown. To investigate the extent to which these RNA structures are conserved across eubacterial phyla, we created multiple sequence alignments representing 10 of these messenger RNA (mRNA) structures in E. coli . We find that while three RNA structures are widely distributed across many phyla of bacteria, seven of the RNAs are narrowly distributed to a few orders of Gammaproteobacteria. To experimentally validate our computational predictions, we biochemically confirmed dual L1-binding sites identified in many Firmicute species. This work reveals that RNA-based regulation of ribosomal protein biosynthesis is used in nearly all eubacterial phyla, but the specific RNA structures that regulate ribosomal protein biosynthesis in E. coli are narrowly distributed. These results highlight the limits of our knowledge regarding ribosomal protein biosynthesis regulation outside of E. coli, and the potential for alternative RNA structures responsible for regulating ribosomal proteins in other eubacteria.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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