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  • Articles  (11)
  • Mitochondria  (11)
  • Springer  (11)
  • 2020-2024
  • 2010-2014
  • 1975-1979  (11)
  • 1955-1959
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  • Articles  (11)
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  • Springer  (11)
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Year
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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural reactions of spinal ganglia to tri-ortho-cresyl-phosphate: Effects of neurotoxicity (1979)
    Springer
    Cell & tissue research 199 (1979), S. 409-414 
    Details
    ISSN: 1432-0878
    Keywords: Spinal ganglion (domestic fowl) ; Tri-ortho-cresyl-phosphate ; Neurofilaments ; Endoplasmic reticulum ; Mitochondria ; Effects of toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ultrastructure of neurons in spinal ganglia of the domestic fowl poisoned with tri-ortho-cresyl-phosphate (TOCP) shows characteristic changes. The light neurons react to TOCP by a marked increase in the number of neurofilaments. These neurons also contain mitochondria in various degenerative stages. Several of the altered mitochondria show an increasing osmiophilia. Some of the darker neurons display a hypertrophy of the endoplasmic reticulum or a relative increase of neurofilaments. The mitochondria in some of these cells show early stages of degeneration. These changes appear 13 days after TOCP ingestion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236079
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  • 2
    Electronic Resource
    Electronic Resource
    Action de la rubratoxine B sur la respiration des mitochondries hépatiques de rat (1975)
    Springer
    Mycopathologia 55 (1975), S. 53-55 
    Details
    ISSN: 1573-0832
    Keywords: Rubratoxine B ; Mitochondria ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The in vitro effect of rubratoxin B on the electron transport system of rat liver mitochondria was investigated. This mycotoxin depressed oxygen consumption in ADP-lacking mitochondria and in ADP-coupled mitochondria, using succinate or β-hydroxybutyrate as substrats. Rubratoxin B is neither an oxidative-phosphorylation inhibitor nor uncoupling agent. Its effect is compared with aflatoxin B1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00467092
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  • 3
    Electronic Resource
    Electronic Resource
    Absence of mitochondrial terminal respiratory enzymes in cartilage matrix vesicles (1977)
    Springer
    Calcified tissue international 24 (1977), S. 37-39 
    Details
    ISSN: 1432-0827
    Keywords: Cartilage ; Matrix vesicles ; Mitochondria ; Respiratory enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary This study attempted to detect evidence of mitochondrial terminal respiratory components in matrix vesicles isolated from rachitic rat tibial epiphyseal plates. Biochemical assays for cytochrome c oxidase, NAD isocitrate dehydrogenase, NADP isocitrate dehydrogenase and succinate-cytochrome c reductase were negative. Polarimetric determinations revealed that the addition of succinate to matrix vesicles in suspension did not cause any increase in oxygen utilization. Spectrophotometric tracings of deoxycholate-solubilized matrix vesicles showed no characteristic absorption peaks or maxima belonging to any of the cytochrome complex components. Attempts to prepare pyridine hemochromes of cytochrome prosthetic groups from the matrix vesicles were also unsuccessful. The above results indicate that key components of mitochondrial respiratory systems are not detectable in rachitic matrix vesicles. The results are compatible with the interpretation that such vesicles are not derived from mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02223294
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  • 4
    Electronic Resource
    Electronic Resource
    An association between mitochondria and vesicles in smooth muscle (1975)
    Springer
    Cell & tissue research 161 (1975), S. 119-132 
    Details
    ISSN: 1432-0878
    Keywords: Muscle, smooth ; Mitochondria ; Cell membrane, vesicles ; Electron microscopy ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two methods are described for measuring the mitochondrion-vesicle association seen by electron-microscopy in thin sections of the guinea-pig taenia coli. Both methods are based on comparisons of the observed distributions with predicted random distributions. It was found in control muscles that mitochondria were consistently nearer to vesicles than corresponding random points. 1 mM ouabain treatment reduced the mitochondrion-vesicle association for mitochondria which were closer to the membrane surface than 130 nm. Quantitative investigation of the freeze-etch structure of the membrane fracture faces is also reported, confirming the observation that membrane particles are more numerous in vesiculated membrane regions of smooth muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222118
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  • 5
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1976)
    Springer
    Cell & tissue research 168 (1976), S. 1-9 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Mitochondria ; ACTH ; Stereology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of chronic administration of ACTH (up to 36 consecutive days) on the mitochondria of the zona reticularis of the rat adrenal cortex were investigated by stereologic techniques. It was found that ACTH induces two phases of hypertrophy of mitochondria alternating with two proliferative stages, which are associated with a significant decrease in the average volume of the organelles. It is suggested that, as in the zona fasciculata, ACTH controls the processes of growth and division of mitochondria in the zona reticularis. The mechanism underlying this action of ACTH as well as the differences between the responses to ACTH of the mitochondrial population of the two adrenal zones are discussed in the light of evidence indicating that mitochondria contain a complete genetic apparatus largely independent of nuclear control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219719
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  • 6
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1975)
    Springer
    Cell & tissue research 163 (1975), S. 273-290 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Mitochondria ; Dexamethasone ; DNA-synthesis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of chronic administration of dexamethasone (for up to 15 consecutive days) on both the morphology and DNA-synthesis of the mitochondria of the rat adrenal zona fasciculata were investigated by stereologic and autoradiographic techniques. Up to the 3rd day of continuous dexamethasone treatment, the average volume of mitochondria did not change, whereas the number of mitochondria per cell was significantly decreased. From the 3rd to the 15th day of hormonal administration both the volume and number of mitochondria were found to decrease in proportion to the duration of treatment. Autoradiography showed that after the 3rd day of dexamethasone administration there is virtually no incorporation of 3H-thymidine into the mitochondrial compartment. These findings are discussed in the light of evidence indicating that dexamethasone blocks ACTH-release by inhibiting the hypothalamo-hypophyseal axis. The results confirm the view that ACTH controls the maintenance of growth and proliferation of rat adrenocortical mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219464
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  • 7
    Electronic Resource
    Electronic Resource
    A light and electron microscope study of changes occurring at the cut ends following section of the dorsal roots of rat spinal nerves (1976)
    Springer
    Cell & tissue research 170 (1976), S. 491-505 
    Details
    ISSN: 1432-0878
    Keywords: Axoplasmic flow ; Mitochondria ; Neurones, dorsal root ganglia ; Spinal nerve roots ; Synaptic vesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rat dorsal spinal nerve roots were cut; 20 h later the axons in the vicinity of the cut were examined by light and electron microscopy. The changes in the cut tip distant from the ganglion were largely degenerative. On the ganglionic side of the cut a cap of free unmyelinated sprouts was formed. These sprouts contained clear and dense-core vesicles 40–150 nm in diameter, smooth endoplasmic reticulum and mitochondria. Some of the unmyelinated sprouts were extensions of myelinated axons, others arose from myelinated axons by lateral budding. In both myelinated and non-myelinated axons there was an accumulation of mitochondria, tubulo-vesicular smooth endoplasmic reticulum and large and small dense-core vesicles for a distance of approximately 500 μm behind the tip. Dense-core vesicles were more common in nonmyelinated axons than in their myelinated counterparts. In areas of intense accumulation the non-myelinated fibres were grossly swollen and distorted. The myelinated axons and some of the sprouts contained an unusual type of mitochondrion. The similarity between these sprouts and pre-synaptic terminals is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361707
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  • 8
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1977)
    Springer
    Cell & tissue research 182 (1977), S. 145-150 
    Details
    ISSN: 1432-0878
    Keywords: Human adrenal cortex ; ACTH ; Mitochondria ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of ACTH on the mitochondria of adult human adrenocortical cells cultured in vitro were investigated by electron microscopic and stereological methods. It was found that ACTH induces an increase in the volume of the mitochondrial compartment, which is due to both a hypertrophy and an increase in number of the organelles. The hypothesis that ACTH controls the growth and proliferation of human adrenocortical mitochondria is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220584
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  • 9
    Electronic Resource
    Electronic Resource
    Morphological, histochemical and biochemical studies on germ cell mitochondria of normal rats (1979)
    Springer
    Cell & tissue research 196 (1979), S. 1-22 
    Details
    ISSN: 1432-0878
    Keywords: Testis ; Germ cells ; Mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Morphological changes in rat germ cell mitochondria are described. In diplotene and secondary spermatocytes and in the spermatids of the Golgi, cap and acrosomal phases, the mitochondria take on a rounded appearance with the inner space containing the matrix flattened against the outer membrane and the intracristal spaces considerably swollen (“condensed” mitochondria). Functional studies on “condensed” mitochondria isolated from the germ cells of normal rats have been performed. The following parameters have been evaluated: ADP/O ratio, respiratory control ratio (RCR) and ADP affinity. The ADP/O values found in the presence of various substrates are in agreement with the theoretical figures. The RCR is remarkably high. Moreover, the ADP affinity of these mitochondria is very high, as demonstrated by the low values of the “apparent Km”. These biochemical findings, which demonstrate a high oxidative capacity coupled with a marked phosphorylation, suggest that the “condensed” appearance of germ cell mitochondria is the expression of an active functional state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236345
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  • 10
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1977)
    Springer
    Cell & tissue research 181 (1977), S. 287-298 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex, zona glomerulosa ; Mitochondria ; ACTH ; Dexamethasone ; Electron microscopy, Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of chronic administration of ACTH and dexamethasone on the morphology of mitochondria in zona glomerulosa cells of the rat adrenal cortex were investigated by Stereological techniques. It was found that the volume of the mitochondrial compartment as well as the surface of the outer and inner mitochondrial membranes were significantly increased or decreased in relation to the number of days of ACTHor dexamethasone-treatment. In ACTH-administered rats, the average volume of individual mitochondria decreased significantly up to the 6th day of treatment and then showed a conspicuous increase from the 6th to the 15th day, whereas in dexamethasone-administered animals this parameter, after a small increase during the first 6 days of treatment, displayed a significant decrease. The number of mitochondria per cell showed a dramatic increase during the first 6 days of treatment with ACTH and continued to increase, but only slightly, with the subsequent treatment. In contrast, this parameter showed a parabolic decrease as a function of the duration of treatment in animals receiving dexamethasone. In the light of evidence showing that dexamethasone blocks ACTH-release, these findings are discussed and interpreted to indicate that ACTH is involved in the maintenance and stimulation of the growth and proliferative activity of mitochondria in rat adrenal zona glomerulosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223104
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