Publication Date:
2014-04-20
Description:
Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment effects achieved by enhancing depression-causing mechanisms in ventral tegmental area (VTA) dopamine (DA) neurons. In a social defeat stress model of depression, depressed (susceptible) mice display hyperactivity of VTA DA neurons, caused by an up-regulated hyperpolarization-activated current (I(h)). Mice resilient to social defeat stress, however, exhibit stable normal firing of these neurons. Unexpectedly, resilient mice had an even larger I(h), which was observed in parallel with increased potassium (K(+)) channel currents. Experimentally further enhancing Ih or optogenetically increasing the hyperactivity of VTA DA neurons in susceptible mice completely reversed depression-related behaviors, an antidepressant effect achieved through resilience-like, projection-specific homeostatic plasticity. These results indicate a potential therapeutic path of promoting natural resilience for depression treatment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334447/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334447/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedman, Allyson K -- Walsh, Jessica J -- Juarez, Barbara -- Ku, Stacy M -- Chaudhury, Dipesh -- Wang, Jing -- Li, Xianting -- Dietz, David M -- Pan, Nina -- Vialou, Vincent F -- Neve, Rachael L -- Yue, Zhenyu -- Han, Ming-Hu -- F31 MH095425/MH/NIMH NIH HHS/ -- F32 MH096464/MH/NIMH NIH HHS/ -- R01 MH092306/MH/NIMH NIH HHS/ -- R01 NS060123/NS/NINDS NIH HHS/ -- T32 MH 087004/MH/NIMH NIH HHS/ -- T32 MH020016/MH/NIMH NIH HHS/ -- T32 MH087004/MH/NIMH NIH HHS/ -- T32 MH096678/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2014 Apr 18;344(6181):313-9. doi: 10.1126/science.1249240.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24744379" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/drug effects
;
Depression/*physiopathology
;
Dopaminergic Neurons/*physiology
;
Electrophysiological Phenomena
;
Homeostasis
;
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
;
Male
;
Membrane Potentials/drug effects
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Optogenetics
;
Patch-Clamp Techniques
;
Potassium Channels/metabolism
;
*Resilience, Psychological
;
Social Behavior
;
Stress, Psychological/*physiopathology
;
Triazines/pharmacology
;
Ventral Tegmental Area/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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