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  • American Association for the Advancement of Science (AAAS)  (34)
  • Copernicus  (31)
  • 2020-2024
  • 2015-2019  (65)
  • 1
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    Human-caused Indo-Pacific warm pool expansion (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-07-03
    Description: The Indo-Pacific warm pool (IPWP) has warmed and grown substantially during the past century. The IPWP is Earth’s largest region of warm sea surface temperatures (SSTs), has the highest rainfall, and is fundamental to global atmospheric circulation and hydrological cycle. The region has also experienced the world’s highest rates of sea-level rise in recent decades, indicating large increases in ocean heat content and leading to substantial impacts on small island states in the region. Previous studies have considered mechanisms for the basin-scale ocean warming, but not the causes of the observed IPWP expansion, where expansion in the Indian Ocean has far exceeded that in the Pacific Ocean. We identify human and natural contributions to the observed IPWP changes since the 1950s by comparing observations with climate model simulations using an optimal fingerprinting technique. Greenhouse gas forcing is found to be the dominant cause of the observed increases in IPWP intensity and size, whereas natural fluctuations associated with the Pacific Decadal Oscillation have played a smaller yet significant role. Further, we show that the shape and impact of human-induced IPWP growth could be asymmetric between the Indian and Pacific basins, the causes of which remain uncertain. Human-induced changes in the IPWP have important implications for understanding and projecting related changes in monsoonal rainfall, and frequency or intensity of tropical storms, which have profound socioeconomic consequences.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-11-07
    Description: T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood. One possible modulator could be the intestinal microbiota. We compared melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, which were eliminated upon cohousing or after fecal transfer. Sequencing of the 16S ribosomal RNA identified Bifidobacterium as associated with the antitumor effects. Oral administration of Bifidobacterium alone improved tumor control to the same degree as programmed cell death protein 1 ligand 1 (PD-L1)-specific antibody therapy (checkpoint blockade), and combination treatment nearly abolished tumor outgrowth. Augmented dendritic cell function leading to enhanced CD8(+) T cell priming and accumulation in the tumor microenvironment mediated the effect. Our data suggest that manipulating the microbiota may modulate cancer immunotherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sivan, Ayelet -- Corrales, Leticia -- Hubert, Nathaniel -- Williams, Jason B -- Aquino-Michaels, Keston -- Earley, Zachary M -- Benyamin, Franco W -- Lei, Yuk Man -- Jabri, Bana -- Alegre, Maria-Luisa -- Chang, Eugene B -- Gajewski, Thomas F -- 5T32CA009594-25/CA/NCI NIH HHS/ -- P30 DK42086/DK/NIDDK NIH HHS/ -- T32 AI007090/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2015 Nov 27;350(6264):1084-9. doi: 10.1126/science.aac4255. Epub 2015 Nov 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Chicago, Chicago, IL 60637, USA. ; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. ; Section of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA. ; Department of Pathology, University of Chicago, Chicago, IL 60637, USA. Department of Medicine, University of Chicago, Chicago, IL 60637, USA. tgajewsk@medicine.bsd.uchicago.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26541606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*therapeutic use ; Antigens, CD274/*immunology ; Bifidobacterium/genetics/*immunology ; CD8-Positive T-Lymphocytes/immunology ; Dendritic Cells/immunology ; Fecal Microbiota Transplantation ; Gastrointestinal Microbiome/*immunology ; Gene Expression Regulation ; Humans ; Immunity/genetics ; Immunotherapy/methods ; Lymphocyte Activation ; Melanoma/*immunology/*therapy ; Mice ; Mice, Inbred C57BL ; RNA, Ribosomal, 16S/genetics ; Skin Neoplasms/*immunology/*therapy ; Symbiosis ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Diamond family of nanoparticle superlattices (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-02-26
    Description: Diamond lattices formed by atomic or colloidal elements exhibit remarkable functional properties. However, building such structures via self-assembly has proven to be challenging because of the low packing fraction, sensitivity to bond orientation, and local heterogeneity. We report a strategy for creating a diamond superlattice of nano-objects via self-assembly and demonstrate its experimental realization by assembling two variant diamond lattices, one with and one without atomic analogs. Our approach relies on the association between anisotropic particles with well-defined tetravalent binding topology and isotropic particles. The constrained packing of triangular binding footprints of truncated tetrahedra on a sphere defines a unique three-dimensional lattice. Hence, the diamond self-assembly problem is solved via its mapping onto two-dimensional triangular packing on the surface of isotropic spherical particles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Wenyan -- Tagawa, Miho -- Xin, Huolin L -- Wang, Tong -- Emamy, Hamed -- Li, Huilin -- Yager, Kevin G -- Starr, Francis W -- Tkachenko, Alexei V -- Gang, Oleg -- AG029979/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2016 Feb 5;351(6273):582-6. doi: 10.1126/science.aad2080.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA. ; Department of Materials Science and Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. ; Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. ; Department of Physics, Wesleyan University, Middletown, CT 06459, USA. ; Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA. ; Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA. ogang@bnl.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912698" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Chemical imaging of Fischer-Tropsch catalysts under operating conditions (2017)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2017-03-18
    Description: Although we often understand empirically what constitutes an active catalyst, there is still much to be understood fundamentally about how catalytic performance is influenced by formulation. Catalysts are often designed to have a microstructure and nanostructure that can influence performance but that is rarely considered when correlating structure with function. Fischer-Tropsch synthesis (FTS) is a well-known and potentially sustainable technology for converting synthetic natural gas ("syngas": CO + H 2 ) into functional hydrocarbons, such as sulfur- and aromatic-free fuel and high-value wax products. FTS catalysts typically contain Co or Fe nanoparticles, which are often optimized in terms of size/composition for a particular catalytic performance. We use a novel, "multimodal" tomographic approach to studying active Co-based catalysts under operando conditions, revealing how a simple parameter, such as the order of addition of metal precursors and promoters, affects the spatial distribution of the elements as well as their physicochemical properties, that is, crystalline phase and crystallite size during catalyst activation and operation. We show in particular how the order of addition affects the crystallinity of the TiO 2 anatase phase, which in turn leads to the formation of highly intergrown cubic close-packed/hexagonal close-packed Co nanoparticles that are very reactive, exhibiting high CO conversion. This work highlights the importance of operando microtomography to understand the evolution of chemical species and their spatial distribution before any concrete understanding of impact on catalytic performance can be realized.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Spatiotemporal mode-locking in multimode fiber lasers (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2017-10-06
    Description: A laser is based on the electromagnetic modes of its resonator, which provides the feedback required for oscillation. Enormous progress has been made toward controlling the interactions of longitudinal modes in lasers with a single transverse mode. For example, the field of ultrafast science has been built on lasers that lock many longitudinal modes together to form ultrashort light pulses. However, coherent superposition of longitudinal and transverse modes in a laser has received little attention. We show that modal and chromatic dispersions in fiber lasers can be counteracted by strong spatial and spectral filtering. This allows locking of multiple transverse and longitudinal modes to create ultrashort pulses with a variety of spatiotemporal profiles. Multimode fiber lasers thus open new directions in studies of nonlinear wave propagation and capabilities for applications.
    Keywords: Physics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus (2017)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2017-11-16
    Description: Middle East respiratory syndrome coronavirus (MERS-CoV) has caused human respiratory infections with a high case fatality rate since 2012. However, the mode of virus transmission is not well understood. The findings of epidemiological and virological studies prompted us to hypothesize that the human gastrointestinal tract could serve as an alternative route to acquire MERS-CoV infection. We demonstrated that human primary intestinal epithelial cells, small intestine explants, and intestinal organoids were highly susceptible to MERS-CoV and can sustain robust viral replication. We also identified the evidence of enteric MERS-CoV infection in the stool specimen of a clinical patient. MERS-CoV was considerably resistant to fed-state gastrointestinal fluids but less tolerant to highly acidic fasted-state gastric fluid. In polarized Caco-2 cells cultured in Transwell inserts, apical MERS-CoV inoculation was more effective in establishing infection than basolateral inoculation. Notably, direct intragastric inoculation of MERS-CoV caused a lethal infection in human DPP4 transgenic mice. Histological examination revealed MERS-CoV enteric infection in all inoculated mice, as shown by the presence of virus-positive cells, progressive inflammation, and epithelial degeneration in small intestines, which were exaggerated in the mice pretreated with the proton pump inhibitor pantoprazole. With the progression of the enteric infection, inflammation, virus-positive cells, and live viruses emerged in the lung tissues, indicating the development of sequential respiratory infection. Taken together, these data suggest that the human intestinal tract may serve as an alternative infection route for MERS-CoV.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018-07-26
    Description: To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/6J x 129S1/SvImJ) F2 mice by measuring 283 affective and sleep phenotypes and profiling gene expression across four brain regions. We identified converging molecular bases for sleep and affective phenotypes at both the single-gene and gene-network levels. Using publicly available transcriptomic datasets collected from sleep-deprived mice and patients with major depressive disorder (MDD), we identified three cortical gene networks altered by the sleep/wake state and depression. The network-level actions of sleep loss and depression were opposite to each other, providing a mechanistic basis for the sleep disruptions commonly observed in depression, as well as the reported acute antidepressant effects of sleep deprivation. We highlight one particular network composed of circadian rhythm regulators and neuronal activity–dependent immediate-early genes. The key upstream driver of this network, Arc , may act as a nexus linking sleep and depression. Our data provide mechanistic insights into the role of sleep in affective function and MDD.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Sociotechnical transitions for deep decarbonization (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2017-09-22
    Keywords: Sociology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Monitoring Atlantic overturning circulation and transport variability with GRACE-type ocean bottom pressure observations – a sensitivity study (2015)
    Copernicus
    Details
    Publication Date: 2015-12-11
    Description: The Atlantic Meridional Overturning Circulation (AMOC) is a key mechanism for large-scale northward heat transport and thus plays an important role for global climate. Relatively warm water is transported northward in the upper layers of the North Atlantic Ocean and, after cooling at subpolar latitudes, sinks down and is transported back south in the deeper limb of the AMOC. The utility of in situ ocean bottom pressure (OBP) observations to infer AMOC changes at single latitudes has been characterized in the recent literature using output from ocean models. We extend the analysis and examine the utility of space-based observations of time-variable gravity and the inversion for ocean bottom pressure to monitor AMOC changes and variability between 20 and 60° N. Consistent with previous results, we find a strong correlation between the AMOC signal and OBP variations, mainly along the western slope of the Atlantic Basin. We then use synthetic OBP data – smoothed and filtered to resemble the resolution of the GRACE (Gravity Recovery and Climate Experiment) gravity mission, but without errors – and reconstruct geostrophic AMOC transport. Due to the coarse resolution of GRACE-like OBP fields, we find that leakage of signal across the step slopes of the ocean basin is a significant challenge at certain latitudes. Transport signal rms is of a similar order of magnitude as error rms for the reconstructed time series. However, the interannual AMOC anomaly time series can be recovered from 20 years of monthly GRACE-like OBP fields with errors less than 1 sverdrup in many locations.
    Print ISSN: 1812-0784
    Electronic ISSN: 1812-0792
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 10
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    Monitoring Atlantic overturning circulation variability with GRACE-type ocean bottom pressure observations – a sensitivity study (2015)
    Copernicus
    Details
    Publication Date: 2015-08-14
    Description: The Atlantic Meridional Overturning Circulation (AMOC) is a key mechanism for large-scale northward heat transport and thus plays an important role for global climate. Relatively warm water is transported northward in the upper layers of the North Atlantic Ocean, and after cooling at subpolar latitudes, sinks down and is transported back south in the deeper limb of the AMOC. The utility of in-situ ocean bottom pressure (OBP) observations to infer AMOC changes at single latitudes has been characterized in recent literature using output from ocean models. We extend the analysis and examine the utility of space-based observations of time-variable gravity and the inversion for ocean bottom pressure to monitor AMOC changes and variability between 20 and 60° N. Consistent with previous results, we find a strong correlation between the AMOC signal and OBP variations, mainly along the western slope of the Atlantic basin. We then use synthetic OBP data – smoothed and filtered to resemble the resolution of the GRACE gravity mission – and reconstruct geostrophic AMOC transport. Due to the coarse resolution of GRACE-like OBP fields, we find that leakage of signal across the step slopes of the ocean basin is a significant challenge at certain latitudes. However, overall, the inter-annual AMOC anomaly time series can be recovered from 20 years of monthly GRACE-like OBP fields with errors less than 1 Sverdrup.
    Print ISSN: 1812-0806
    Electronic ISSN: 1812-0822
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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