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The Earth BioGenome Project 2020: starting the clock (2022)

Lewin, Harris A. ; Richards, Stephen ; Miguel L. Allende ; [weitere]

National Academy of Sciences

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Publikationsdatum: 2022-05-27

Beschreibung: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Lewin, H. A., Richards, S., Lieberman Aiden, E., Allende, M. L., Archibald, J. M., Bálint, M., Barker, K. B., Baumgartner, B., Belov, K., Bertorelle, G., Blaxter, Mark L., Cai, J., Caperello, N. D., Carlson, K., Castilla-Rubio, J. C., Chaw, S-M., Chen, L., Childers, A. K., Coddington, J. A., Conde, D. A., Corominas, M., Crandall, K. A., Crawford, A. J., DiPalma, F., Durbin, R., Ebenezer, T. E., Edwards, S. V., Fedrigo, O., Flicek, P., Formenti, G., Gibbs, R. A., Gilbert, M. Thomas P., Goldstein, M. M., Graves, J. M., Greely, H. T., Grigoriev, I. V., Hackett, K. J., Hall, N., Haussler, D., Helgen, K. M., Hogg, C. J., Isobe, S., Jakobsen, K. S., Janke, A., Jarvis, E. D., Johnson, W. E., Jones, S. J. M., Karlsson, E. K., Kersey, P. J., Kim, J-H., Kress, W. J., Kuraku, S., Lawniczak, M. K. N., Leebens-Mack, J. H., Li, X., Lindblad-Toh, K., Liu, X., Lopez, J. V., Marques-Bonet, T., Mazard, S., Mazet, J. A. K., Mazzoni, C. J., Myers, E. W., O’Neill, R. J., Paez, S., Park, H., Robinson, G. E., Roquet, C., Ryder, O. A., Sabir, J. S. M., Shaffer, H. B., Shank, T. M., Sherkow, J. S., Soltis, P. S., Tang, B., Tedersoo, L., Uliano-Silva, M., Wang, K., Wei, X., Wetzer, R., Wilson, J. L., Xu, X., Yang, H., Yoder, A. D., Zhang, G. The Earth BioGenome Project 2020: starting the clock. Proceedings of the National Academy of Sciences of the United States of America, 119(4), (2022): e2115635118, https://doi.org/10.1073/pnas.2115635118.

Beschreibung: November 2020 marked 2 y since the launch of the Earth BioGenome Project (EBP), which aims to sequence all known eukaryotic species in a 10-y timeframe. Since then, significant progress has been made across all aspects of the EBP roadmap, as outlined in the 2018 article describing the project’s goals, strategies, and challenges (1). The launch phase has ended and the clock has started on reaching the EBP’s major milestones. This Special Feature explores the many facets of the EBP, including a review of progress, a description of major scientific goals, exemplar projects, ethical legal and social issues, and applications of biodiversity genomics. In this Introduction, we summarize the current status of the EBP, held virtually October 5 to 9, 2020, including recent updates through February 2021. References to the nine Perspective articles included in this Special Feature are cited to guide the reader toward deeper understanding of the goals and challenges facing the EBP.

Repository-Name: Woods Hole Open Access Server

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New Broad Spectrum Anthelmintic, Methyl 5(6)-Butyl-2-benzimidazolecarbamate (1967)

ACTOR, P. ; ANDERSON, E. L. ; DICUOLLO, C. J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 215 (1967), S. 321-322

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Fig. 1. Left hand side, anthelmintic benzimidazoles I (a) (X = S, R = OC2H5); (b)(X = O,R = alkyl); (c) (X = O, R = alkoxy); (d)(X = O, R = alkylamino). Right hand side, anthelmintic benzimidazole II (SK and F 29044). In our first efficacy trials with SK and F 29044 we used mice infected with ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/215321a0

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Global collision-risk hotspots of marine traffic and the world’s largest fish, the whale shark (2022)

Womersley, Freya C. ; Humphries, Nicolas E. ; Queiroz, Nuno ; [weitere]

National Academy of Sciences

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Publikationsdatum: 2022-08-15

Beschreibung: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Womersley, F. C., Humphries, N. E., Queiroz, N., Vedor, M., da Costa, I., Furtado, M., Tyminski, J. P., Abrantes, K., Araujo, G., Bach, S. S., Barnett, A., Berumen, M. L., Bessudo Lion, S., Braun, C. D., Clingham, E., Cochran, J. E. M., de la Parra, R., Diamant, S., Dove, A. D. M., Dudgeon, C. L., Erdmann, M. V., Espinoza, E., Fitzpatrick, R., González Cano, J., Green, J. R., Guzman, H. M., Hardenstine, R., Hasan, A., Hazin, F. H. V., Hearn, A. R., Hueter, R. E., Jaidah, M. Y., Labaja, J., Ladinol, F., Macena, B. C. L., Morris Jr., J. J., Norman, B. M., Peñaherrera-Palmav, C., Pierce, S. J., Quintero, L. M., Ramırez-Macías, D., Reynolds, S. D., Richardson, A. J., Robinson, D. P., Rohner, C. A., Rowat, D. R. L., Sheaves, M., Shivji, M. S., Sianipar, A. B., Skomal, G. B., Soler, G., Syakurachman, I., Thorrold, S. R., Webb, D. H., Wetherbee, B. M., White, T. D., Clavelle, T., Kroodsma, D. A., Thums, M., Ferreira, L. C., Meekan, M. G., Arrowsmith, L. M., Lester, E. K., Meyers, M. M., Peel, L. R., Sequeira, A. M. M., Eguıluz, V. M., Duarte, C. M., & Sims, D. W. Global collision-risk hotspots of marine traffic and the world’s largest fish, the whale shark. Proceedings of the National Academy of Sciences of the United States of America, 119(20), (2022): e2117440119, https://doi.org/10.1073/pnas.2117440119.

Beschreibung: Marine traffic is increasing globally yet collisions with endangered megafauna such as whales, sea turtles, and planktivorous sharks go largely undetected or unreported. Collisions leading to mortality can have population-level consequences for endangered species. Hence, identifying simultaneous space use of megafauna and shipping throughout ranges may reveal as-yet-unknown spatial targets requiring conservation. However, global studies tracking megafauna and shipping occurrences are lacking. Here we combine satellite-tracked movements of the whale shark, Rhincodon typus, and vessel activity to show that 92% of sharks’ horizontal space use and nearly 50% of vertical space use overlap with persistent large vessel (〉300 gross tons) traffic. Collision-risk estimates correlated with reported whale shark mortality from ship strikes, indicating higher mortality in areas with greatest overlap. Hotspots of potential collision risk were evident in all major oceans, predominantly from overlap with cargo and tanker vessels, and were concentrated in gulf regions, where dense traffic co-occurred with seasonal shark movements. Nearly a third of whale shark hotspots overlapped with the highest collision-risk areas, with the last known locations of tracked sharks coinciding with busier shipping routes more often than expected. Depth-recording tags provided evidence for sinking, likely dead, whale sharks, suggesting substantial “cryptic” lethal ship strikes are possible, which could explain why whale shark population declines continue despite international protection and low fishing-induced mortality. Mitigation measures to reduce ship-strike risk should be considered to conserve this species and other ocean giants that are likely experiencing similar impacts from growing global vessel traffic.

Beschreibung: Funding for data analysis was provided by the UK Natural Environment Research Council (NERC) through a University of Southampton INSPIRE DTP PhD Studentship to F.C.W. Additional funding for data analysis was provided by NERC Discovery Science (NE/R00997/X/1) and the European Research Council (ERC-AdG-2019 883583 OCEAN DEOXYFISH) to D.W.S., Fundação para a Ciência e a Tecnologia (FCT) under PTDC/BIA/28855/2017 and COMPETE POCI-01–0145-FEDER-028855, and MARINFO–NORTE-01–0145-FEDER-000031 (funded by Norte Portugal Regional Operational Program [NORTE2020] under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund–ERDF) to N.Q. FCT also supported N.Q. (CEECIND/02857/2018) and M.V. (PTDC/BIA-COM/28855/2017). D.W.S. was supported by a Marine Biological Association Senior Research Fellowship. All tagging procedures were approved by institutional ethical review bodies and complied with all relevant ethical regulations in the jurisdictions in which they were performed. Details for individual research teams are given in SI Appendix, section 8. Full acknowledgments for tagging and field research are given in SI Appendix, section 7. This research is part of the Global Shark Movement Project (https://www.globalsharkmovement.org).

Schlagwort(e): ship strike ; marine megafauna ; conservation ; movement ecology ; human impact

Repository-Name: Woods Hole Open Access Server

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High (3)He/(4)He in central Panama reveals a distal connection to the Galápagos plume (2022)

Bekaert, David V. ; Gazel, Esteban ; Turner, Stephen ; [weitere]

National Academy of Sciences

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Publikationsdatum: 2022-10-26

Beschreibung: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Bekaert, D. V., Gazel, E., Turner, S., Behn, M. D., de Moor, J. M., Zahirovic, S., Manea, V. C., Hoernle, K., Fischer, T. P., Hammerstrom, A., Seltzer, A. M., Kulongoski, J. T., Patel, B. S., Schrenk, M. O., Halldórsson, S. A., Nakagawa, M., Ramírez, C. J., Krantz, J. A., Yücel, M., Ballentine, C. J., Giovannelli, D., Lloyd, K. G., Barry, P. H. High (3)He/(4)He in central Panama reveals a distal connection to the Galápagos plume. Proceedings of the National Academy of Sciences of the United States of America, 118(47), (2021): e2110997118, https://doi.org/10.1073/pnas.2110997118.

Beschreibung: It is well established that mantle plumes are the main conduits for upwelling geochemically enriched material from Earth's deep interior. The fashion and extent to which lateral flow processes at shallow depths may disperse enriched mantle material far (〉1,000 km) from vertical plume conduits, however, remain poorly constrained. Here, we report He and C isotope data from 65 hydrothermal fluids from the southern Central America Margin (CAM) which reveal strikingly high 3He/4He (up to 8.9RA) in low-temperature (≤50 °C) geothermal springs of central Panama that are not associated with active volcanism. Following radiogenic correction, these data imply a mantle source 3He/4He 〉10.3RA (and potentially up to 26RA, similar to Galápagos hotspot lavas) markedly greater than the upper mantle range (8 ± 1RA). Lava geochemistry (Pb isotopes, Nb/U, and Ce/Pb) and geophysical constraints show that high 3He/4He values in central Panama are likely derived from the infiltration of a Galápagos plume–like mantle through a slab window that opened ∼8 Mya. Two potential transport mechanisms can explain the connection between the Galápagos plume and the slab window: 1) sublithospheric transport of Galápagos plume material channeled by lithosphere thinning along the Panama Fracture Zone or 2) active upwelling of Galápagos plume material blown by a “mantle wind” toward the CAM. We present a model of global mantle flow that supports the second mechanism, whereby most of the eastward transport of Galápagos plume material occurs in the shallow asthenosphere. These findings underscore the potential for lateral mantle flow to transport mantle geochemical heterogeneities thousands of kilometers away from plume conduits.

Beschreibung: This work was principally supported by Grant G-2016-7206 from the Alfred P. Sloan Foundation and the Deep Carbon Observatory to P.H.B. We also acknowledge the NSF awards (1144559, 1923915, and 2015789) to P.H.B., which partially supported this work. S.Z. was supported by the Australian Research Council Grant DE210100084 and a University of Sydney Robinson Fellowship. D.G. was partially supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program Grant Agreement No. 948972—COEVOLVE—ERC-2020-STG. This study was also supported in part by NSF award No. EAR 1826673 to E.G. Folkmar Hauff is acknowledged for contributing to the analysis of the La Providencia samples at GEOMAR.

Schlagwort(e): Helium ; Mantle plume ; Slab window ; Mantle flow ; Geochemistry

Repository-Name: Woods Hole Open Access Server

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Inhibition of Rhinovirus by Isatin Thiosemicarbazone Analogues (1969)

GLADYCH, J. M. Z. ; HUNT, J. H. ; JACK, D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 221 (1969), S. 286-287

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] The following compounds were tested: (A) R = H; isatin 3-thiosemicarbazone; (B) R = CH3; 1-methylisatin 3-thiosemicarbazone; (C)3,10-Dimethyl-10H-s-triazolo[4,3 : 2,3]-as-triazino-[5,6-b]indole; (D) R = H; 3-[(5-methyl-5H-as-triazino[5,6-b]indol-3-yl)amino]-1-propanol; (E) R = CH3; ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/221286b0

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Tetramisole ( R 8299), A New, Potent Broad Spectrum Anthelmintic (1966)

THIENPONT, D. ; VANPARIJS, O. F. J. ; RAEYMAEKERS, A. H. M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 209 (1966), S. 1084-1086

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] THIS article reports the discovery of tetramisole (R 8299 (I)), a new, potent broad spectrum anthelmintic, which is at present undergoing large-scale clinical trials in several countries. In the course of our routine screening programme for anthelmintic activity the aminothiazol derivative (II) ...

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URL: http://dx.doi.org/10.1038/2091084a0

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Significance of ADP, Plasma and Platelet Concentration in Platelet Electrophoretic Studies (1968)

BETTS, J. J. ; BETTS, J. P. ; NICHOLSON, J. T.

[s.l.] : Nature Publishing Group

Nature 219 (1968), S. 1280-1282

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Platelet electrophoretic mobilities were determined at 25 C, unless otherwise stated, using the procedure described by Hampton and Mitchell7. With the platelet systems used it was found unnecessary to "glass contact" the PRP in order to induce biphasic mobility changes with ADP. Platelet counts ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/2191280b0

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Concurrent Measurement of Renin and Angiotensin in the Circulation of the Dog (1967)

BROWN, J. J. ; LEVER, A. F. ; ROBERTSON, J. I. S. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 215 (1967), S. 853-855

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] We report here an extension of this work in which changes in the concentration of plasma renin, the rate of generation of angiotensin and the concentration of angiotensin in the blood were measured concurrently. Fig. 1. Dog 2. The responses of three blood-bathed tissues to (i) angio-tensin infused ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/215853a0

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Pyrantel Tartrate, a New Anthelmintic Effective against Infections of Domestic Animals (1966)

AUSTIN, W. C. ; COURTNEY, W. ; DANILEWICZ, J. C. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 212 (1966), S. 1273-1274

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] These substances were first tested for anthelmintic activity against Nematospiroides dubius in mice and Nippostrongylus muris in rats. Compounds (I)-(VI) were among the most active to emerge from these tests, and their potency increased roughly in that order. They have all been evaluated in sheep. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/2121273b0

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Erythrocytic Enzymes of Various Animal Species (1965)

SMITH, J. ; BARNES, J. K. ; KANEKO, J. J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 205 (1965), S. 298-299

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] The sheep and goat have been reported to be completely void of erythroeyte glucose-6-phosphate dehydrogonase (G-6-PD) activity by several investigators3,4, while others have reported very low activity5,'6. There is, however, no reported evidence of increased drug sensitivity associated with these ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/205298a0

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