Publication Date:
1980-07-18
Description:
Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pepper, C M -- Henderson, G -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):394-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384811" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Endorphins/*pharmacology
;
*Enkephalin, Methionine/*analogs & derivatives
;
Enkephalins/*pharmacology
;
Guinea Pigs
;
Locus Coeruleus/drug effects/*physiology
;
Membrane Potentials/drug effects
;
Morphine Derivatives/*pharmacology
;
Naloxone/*pharmacology
;
Neurons/drug effects/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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