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  • 1
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    Unknown
    Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse (2022)
    Nature Research
    Details
    Publication Date: 2022-09-23
    Description: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pattanayak, R., Underwood, R., Crowley, M. R., Crossman, D. K., Morgan, J. R., & Yacoubian, T. A. Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse. Scientific Reports, 12(1), (2022): 9837, https://doi.org/10.1038/s41598-022-13557-8.
    Description: We report an incidental 358.5 kb deletion spanning the region encoding for alpha-synuclein (αsyn) and multimerin1 (Mmrn1) in the Rab27a/Rab27b double knockout (DKO) mouse line previously developed by Tolmachova and colleagues in 2007. Western blot and RT-PCR studies revealed lack of αsyn expression at either the mRNA or protein level in Rab27a/b DKO mice. PCR of genomic DNA from Rab27a/b DKO mice demonstrated at least partial deletion of the Snca locus using primers targeted to exon 4 and exon 6. Most genes located in proximity to the Snca locus, including Atoh1, Atoh2, Gm5570, Gm4410, Gm43894, and Grid2, were shown not to be deleted by PCR except for Mmrn1. Using whole genomic sequencing, the complete deletion was mapped to chromosome 6 (60,678,870–61,037,354), a slightly smaller deletion region than that previously reported in the C57BL/6J substrain maintained by Envigo. Electron microscopy of cortex from these mice demonstrates abnormally enlarged synaptic terminals with reduced synaptic vesicle density, suggesting potential interplay between Rab27 isoforms and αsyn, which are all highly expressed at the synaptic terminal. Given this deletion involving several genes, the Rab27a/b DKO mouse line should be used with caution or with appropriate back-crossing to other C57BL/6J mouse substrain lines without this deletion.
    Description: This study was supported by NIH [R56NS115767 (TAY), RF1NS115767-01A1 (TAY), P50NS108675 (TAY), and NINDS/NIA RF1NS078165 (JRM)].
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Electronic Resource
    Electronic Resource
    Peroxidation of saccharide phenylhydrazones: novel hydrazono-1,4-lactones (1991)
    s.l. : American Chemical Society
    The @journal of organic chemistry 56 (1991), S. 6944-6946 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00024a046
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Vegetation dynamics in impounded marshes along the Indian River Lagoon, Florida, USA (1990)
    Springer
    Environmental management 14 (1990), S. 397-409 
    Details
    ISSN: 1432-1009
    Keywords: Batis ; Impoundment ; Mangroves ; Salicornia ; Salt marsh ; Vegetation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Data are presented on the vegetation dynamics of two impounded marshes along the Indian River Lagoon, in east-central Florida, USA. Vegetation in one of the marshes (IRC 12) was totally eliminated by overflooding and by hypersaline conditions (salinities over 100 ppt) that developed there in 1979 after the culvert connecting the marsh with the lagoon was closed. Over 20% recovery of the herbaceous halophytesSalicornia virginica, S. bigelovii, andBatis maritima was observed at that site after the culvert was reopened in 1982, but total cover in the marsh remains well below the original 75%. No recovery of mangroves was observed at this site. The second site (SLC 24), while remaining isolated from the lagoon during much of the study, did not suffer the complete elimination of vegetation experienced at the first site. At this location, mangroves increased in cover and frequency with a concomitant decrease in herbaceous halophytes. Considerable damage to the vegetation was evident at IRC 12 when the impoundment was closed and flooded for mosquito control in 1986. Although the damage was temporary, its occurrence emphasizes the need of planning and constant monitoring and adjustment of management details as conditions within particular marshes change. Storms and hurricanes may be important in promoting a replacement of black mangroves by red mangroves in closed impoundments because the former cannot tolerate pneumatophore submergence for long periods of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02394208
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  • 4
    Electronic Resource
    Electronic Resource
    Chromosomal localization and molecular-marker tagging of the powdery mildew resistance gene (Lv) in tomato (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 76-79 
    Details
    ISSN: 1432-2242
    Keywords: Powdery mildew (Leveillula taurica) ; Tomato ; RAPD ; RFLP ; Lv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We report the tagging of a powdery mildew [Leveillula taurica (Lév.) Arnaud.] resistance gene (Lv) in tomato using RAPD and RFLP markers. DNA from a resistant (cv Laurica) and a susceptible cultivar were screened with 300 random primers that were used to amplify DNA of resistant and susceptible plants. Four primers yielded fragments that were unique to the resistant line and linked to the resistance gene in an F2 population. One of these amplified fragments, OP248, with a molecular weight of 0.7 kb, was subsequently mapped to chromosome 12, 1 cM away from CT134. Using RFLP markers located on chromosome 12, it was shown that approximately one half of chromosome 12 (about 42 cM), in the resistant variety is comprised of foreign DNA, presumably introgressed with the resistance gene from the wild species L. chilense. Further analysis of a backcross population revealed that the Lv gene lies in the 5.5-cM interval between RFLP markers, CT211 and CT219. As a prelude to map-based cloning of the Lv gene, we are currently enriching the density of markers in this region by a combination of RAPD primers and other techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226986
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  • 5
    Electronic Resource
    Electronic Resource
    Hunger-dependent predator inspection and foraging behaviours in the threespine stickleback (Gasterosteus aculeatus) under predation risk (1994)
    Springer
    Behavioral ecology and sociobiology 34 (1994), S. 359-366 
    Details
    ISSN: 1432-0762
    Keywords: Predation risk ; Hunger ; Predator inspection ; Foraging ; Fish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Individual fish commonly leave the relative safety of the shoal to approach potential predators at a distance. Not all members of a shoal are equally likely to initiate such predator inspection visits. Here, we show for the first time that the current hunger state of individual fish strongly influences their predator inspection behaviour, as well as their foraging rate, in the face of predation hazard. When all members of threespine stickleback (Gasterosteus aculeatus) test shoals were in a similar hunger state, they were equally likely to inspect a trout predator model alone and did not differ in the frequency of their inspection visits or foraging rate. However, when individual sticklebacks in a shoal differed in their hunger state, the food-deprived (i.e. hungrier) member of the shoal fed at a higher rate, was significantly more likely to initiate solitary predator inspection visits, and inspected the predator model significantly more often than its less hungry (i.e. well-fed) shoal mates. Individual fish which inspected the predator model more frequently also tended to have higher feeding rates. The results indicate that the hungrier fish in a shoal are more willing to take greater risks to inspect a potential threat at a distance, compared with their well-fed shoal mates, and suggest that they may gain a foraging benefit in doing so. If marked asymmetries in hunger state exist among members of fish shoals, then mutual cooperation during predator inspection visits may be difficult to achieve because well-fed individuals are not as likely to initiate or participate in inspection visits as are hungry individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01209782
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Hunger-dependent predator inspection and foraging behaviours in the threespine stickleback (Gasterosteus aculeatus) under predation risk (1994)
    Springer
    Behavioral ecology and sociobiology 34 (1994), S. 359-366 
    Details
    ISSN: 1432-0762
    Keywords: Key words: Predation risk ; Hunger ; Predator inspection ; Foraging ; Fish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Individual fish commonly leave the relative safety of the shoal to approach potential predators at a distance. Not all members of a shoal are equally likely to initiate such predator inspection visits. Here, we show for the first time that the current hunger state of individual fish strongly influences their predator inspection behaviour, as well as their foraging rate, in the face of predation hazard. When all members of threespine stickleback (Gasterosteus aculeatus) test shoals were in a similar hunger state, they were equally likely to inspect a trout predator model alone and did not differ in the frequency of their inspection visits or foraging rate. However, when individual sticklebacks in a shoal differed in their hunger state, the food-deprived (i.e. hungrier) member of the shoal fed at a higher rate, was significantly more likely to initiate solitary predator inspection visits, and inspected the predator model significantly more often than its less hungry (i.e. well-fed) shoal mates. Individual fish which inspected the predator model more frequently also tended to have higher feeding rates. The results indicate that the hungrier fish in a shoal are more willing to take greater risks to inspect a potential threat at a distance, compared with their well-fed shoal mates, and suggest that they may gain a foraging benefit in doing so. If marked asymmetries in hunger state exist among members of fish shoals, then mutual cooperation during predator inspection visits may be difficult to achieve because well-fed individuals are not as likely to initiate or participate in inspection visits as are hungry individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01209782
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  • 7
    Electronic Resource
    Electronic Resource
    Hunger-dependent predator inspection and foraging behaviours in the threespine stickleback (Gasterosteus aculeatus) under predation risk (1994)
    Springer
    Behavioral ecology and sociobiology 34 (1994), S. 359-366 
    Details
    ISSN: 1432-0762
    Keywords: Predation risk ; Hunger ; Predator inspection ; Foraging ; Fish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Individual fish commonly leave the relative safety of the shoal to approach potential predators at a distance. Not all members of a shoal are equally likely to initiate such predator inspection visits. Here, we show for the first time that the current hunger state of individual fish strongly influences their predator inspection behaviour, as well as their foraging rate, in the face of predation hazard. When all members of threespine stickleback (Gasterosteus aculeatus) test shoals were in a similar hunger state, they were equally likely to inspect a trout predator model alone and did not differ in the frequency of their inspection visits or foraging rate. However, when individual sticklebacks in a shoal differed in their hunger state, the food-deprived (i.e. hungrier) member of the shoal fed at a higher rate, was significantly more likely to initiate solitary predator inspection visits, and inspected the predator model significantly more often than its less hungry (i.e. well-fed) shoal mates. Individual fish which inspected the predator model more frequently also tended to have higher feeding rates. The results indicate that the hungrier fish in a shoal are more willing to take greater risks to inspect a potential threat at a distance, compared with their well-fed shoal mates, and suggest that they may gain a foraging benefit in doing so. If marked asymmetries in hunger state exist among members of fish shoals, then mutual cooperation during predator inspection visits may be difficult to achieve because well-fed individuals are not as likely to initiate or participate in inspection visits as are hungry individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197006
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  • 8
    Electronic Resource
    Electronic Resource
    Ileal lipid-binding protein (Illbp) gene maps to mouse Chromosome 11 (1994)
    Springer
    Mammalian genome 5 (1994), S. 805-806 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292019
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  • 9
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    Unknown
    Effects of re-establishing tidal connections in two impounded subtropical marshes on fishes and physical conditions (1990)
    Springer
    Details
    Publication Date: 1990-06-01
    Print ISSN: 0277-5212
    Electronic ISSN: 1943-6246
    Topics: Biology
    Published by Springer
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  • 10
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    Unknown
    Above-ground primary production in impounded, ditched, and naturalBatis-salicornia marshes along the Indian River Lagoon, Florida, U.S.A. (1990)
    Springer
    Details
    Publication Date: 1990-12-01
    Print ISSN: 0277-5212
    Electronic ISSN: 1943-6246
    Topics: Biology
    Published by Springer
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