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  • 03. Hydrosphere::03.03. Physical::03.03.05. Instruments and techniques  (1)
  • 04.03. Geodesy  (1)
  • 6-phosphofructo-2-kinase  (1)
  • 2020-2023  (1)
  • 2015-2019  (1)
  • 1995-1999  (1)
  • 1965-1969
Collection
Keywords
Publisher
Years
  • 2020-2023  (1)
  • 2015-2019  (1)
  • 1995-1999  (1)
  • 1965-1969
  • 2010-2014  (1)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 156 (1996), S. 125-130 
    ISSN: 1573-4919
    Keywords: fructose 2,6-bisphosphate ; 6-phosphofructo-2-kinase ; K562 cell differentiation ; MEG-01 cell differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Fructose 2,6-bisphosphate (Fru-2,6-P2) represents the most powerful activator of 6-phosphofructo-l-kinase, rate-limiting enzyme of glycolysis. Fru-2,6-P2 content is tightly regulated and appears to be under the control of different hormones and growth factors, acting either through covalent modification of isoenzymatic forms of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK-2/FBPase-2), the bifunctional enzyme responsible for the synthesis and the degradation of the compound, or through changes in transcription rate and/or in the expression of different isoforms of the enzyme. In the present study the metabolism of Fru-2,6-P2 was investigated during the differentiation toward megakaryocytes induced by phorbol 12-myristate 13-acetate (PMA) treatment of human leukemia K562 and MEG-O1 cell lines. Fru-2,6-P2 content as well as PFK-2 activity were increased in a dose-dependent manner after 4 days of incubation with PMA. MEG-01 cells resulted more sensitive to the effect of the inducer, anyway in both cell types cytostatic concentrations of the phorbol ester were able to affect Fru-2,6-P2 metabolism. The effect of PMA was maximal at 4 days of incubation in both examined cell lines. Interestingly, the effect induced by the phorbol ester at 4 days was still appreciable subculturing K562 and MEG-01 cells for 3 days in the absence of the inducer and was associated with relevant changes in the molecular properties of PFK-2: namely increased Vmax and Km. This latter finding suggests that the rise in Fru-2,6-P2 content during the differentiation process toward megakaryocytes might result from the expression of a novel PFK-2 isoform.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2017-04-04
    Description: The NEMO-SN1 (NEutrino Mediterranean Observatory - Submarine Network 1) seafloor observatory is located in the central Mediterranean, Western Ionian Sea, off Eastern Sicily Island (Southern Italy) at 2100 m water depth, 25 km from the harbour of the city of Catania. It is a prototype of cabled deep-sea multiparameter observatory, and the first operating with real-time data transmission in Europe since 2005. NEMO-SN1 is also the first-established node of EMSO (European Multidisciplinary Seafloor Observatory, http://emso-eu.org), one of the European large-scale research infrastructures. EMSO will address long-term monitoring of environmental processes related to marine ecosystems, climate change and geo-hazards. NEMO-SN1 will perform geophysical and environmental long-term monitoring by acquiring seismological, geomagnetic, gravimetric, accelerometric, physico-oceanographic, hydro-acoustic, bio-acoustic measurements to study earthquake and tsunami generation, and to characterize ambient noise which includes marine mammal sounds, and environmental and anthropogenic sources. NEMO-SN1 is also equipped with a prototype tsunami detector, based on the simultaneous measurement of the seismic and bottom pressure signals and a new high performance tsunami detection algorithm. NEMO-SN1 will be a permanent tsunami early warning node in Western Ionian Sea, an area where very destructive earthquakes have occurred in the past, some of them tsunamigenic (e.g., 1693, M=7.5; 1908, M=7.4). Another important feature of NEMO-SN1 is the installation of a low frequency-high sensibility hydrophone and two (scalar and vector, respectively) magnetometers. The objective is to improve the tsunami detection capability of SN1 through the recognition of tsunami-induced hydro-acoustic and electro-magnetic precursors.
    Description: Submitted
    Description: Rhodes, Greece
    Description: 3A. Ambiente Marino
    Description: restricted
    Keywords: Tsunami ; Detection ; Precursors and Early Warning ; Abyssal Multidisciplinary Observatories ; EMSO ; 03. Hydrosphere::03.03. Physical::03.03.05. Instruments and techniques
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
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  • 3
    Publication Date: 2022-12-01
    Description: The Global Navigation Satellite System (GNSS) represents a primary data source in Solid Earth Sciences. In order to investigate the Earth’s crustal deformation, time series of the estimated daily positions of the stations are routinely analyzed at the Istituto Nazionale di Geofisica e Vulcanologia (INGV) to investigate the deformation of the Earth’s surface caused by tectonic and non-tectonic processes. The GNSS observations of the stations are processed using the three main scientific software: GAMIT/GLOBK, BERNESE, and GIPSY OASIS II. The accuracy and the strength of geodetic solutions often depend on the geometry and spatial density of the network, and the availability and quality of GNSS data. In many circumstances, GNSS networks are deployed for topographic purposes by private or public institutions, and a significant number of GNSS stations in large regions acquire continuous observations. It may happen that such networks do not collect and distribute data according to IGS standards, so it could be difficult to analyze this data using automated data-processing tools. For that reason, this data is often ignored or partially used by the scientific community, despite their potential usefulness in geodynamic studies. We have attempted troubleshooting this problem by establishing a centralized storage facility in order to collect all available GNSS data and standardize both formats and metadata information. Here we describe the processes and functions that manage this unified repository, called MGA (Mediterranean GNSS Archive), which regularly collects GNSS RINEX files from alarge number of CORS (Continuously Operating Reference Station) located across a wide region of mainly the European and African plates. RINEX observation data and metadata information are provided to the analysts through an FTP server and dedicated web-services. The complete data set is stored in a PostgreSQL database in order to easily retrieve pieces of information and efficiently manage the archive content. The system implements many high-level services that include scripts to download files from remote archives and to detect new available data, web applications such as API (Application Program Interface) to interact with the system, and background services that interact with the database. During the development of this product, particular attention was paid to what has already been achieved by EPOS TCS WP10, whose objective was: "[...] to develop an open source platform with programmatic and web interfaces to store and disseminate raw data and metadata from GNSS stations operating in Europe''. Many ideas and tools presented here were inspired by that project.
    Description: Published
    Description: 1-18
    Description: 2T. Deformazione crostale attiva
    Description: 1IT. Reti di monitoraggio e sorveglianza
    Description: 4IT. Banche dati
    Description: N/A or not JCR
    Keywords: RINEX ; GNSS ARCHIVE ; GNSS MEDITERRANEAN AREA ; 04.03. Geodesy
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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