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  • 1
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    Comparison of the Antioxidant Activities and Phenolic Content of Five Lonicera Flowers by HPLC-DAD/MS-DPPH and Chemometrics (2020)
    Hindawi
    Details
    Publication Date: 2020-04-01
    Description: The Lonicera plants (family Caprifoliaceae) with strong antioxidant activity are used as potential health-supporting phytochemicals. Studying the detailed relationships between bioactive compounds and their antioxidant activity is important for further comprehensive development and application of them. In this paper, the antioxidant capacities and compositions of five species of Lonicera flowers were investigated by using the online HPLC-DAD/MS-DPPH method. Results indicated that the samples contained higher amounts of phenols had better antioxidant activity. Furthermore, principal component analysis and linear regression were further used to analyze the correlations between antioxidant capacity and compounds and find the compounds having higher contribution to antioxidant activity. 5-O-Caffeoylquinic acid, 4-O-caffeoylshikimic acid, methyl-5-O-caffeoylquinate, 1,4-di-O-caffeoylquinic acid, and 3,4,5-tri-O-caffeoylquinic acid were screened as stronger antioxidant candidates. In this study, HPLC-DAD/MS and antioxidant activity methods were combined together to analyze the compounds’ information and activity assays of Lonicera, which might provide more evidence for its quality control.
    Print ISSN: 1687-8760
    Electronic ISSN: 1687-8779
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 2
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    A GC-MS-Based Metabolomics Investigation of the Protective Effect of Liu-Wei-Di-Huang-Wan in Type 2 Diabetes Mellitus Mice (2020)
    Hindawi
    Details
    Publication Date: 2020-08-13
    Description: Aim of the Study. The present study aimed to establish a metabolic profile and to investigate the changes of endogenous metabolites in diabetic mice treated with LWDHW. We further investigated the metabolic mechanism of action for the hypoglycemic activity of LWDHW and its possible role in reducing the risk of renal failure in type 2 diabetic mice. Materials and Methods. MKR mice were used for the development of diabetes with high-fat diet feeding. These mice were further injected with streptozocin (STZ) to aggravate kidney failure. Fasting blood glucose (FBG) and urinary albumin-to-creatinine ratio (ACR values) were determined to validate the successful establishment of diabetic models with desired kidney dysfunction. Metabolomics approach coupled with gas chromatography-mass spectrometry (GC-MS) and random forest (RF) algorithm was proposed to discover the metabolic differences among model group and control group as well as to examine the therapeutic efficacy of traditional Chinese medicine, Liu-Wei-Di-Huang-Wan (LWDHW), in diabetes and associated kidney failure. Results. Some metabolites such as 3-hydroxybutyric acid, citric acid, hexadecanoic acid, and octadecanoic acid showed significant differences between the control group and model group. Treatment with LWDHW resulted in a significant decrease in FBG and ACR values. These results suggested that LWDHW could have beneficial effects in diabetes-associated renal failure.
    Print ISSN: 1687-8760
    Electronic ISSN: 1687-8779
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 3
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    Interference Analysis of Metal Conductors for Target-Resonance-Based Detection Method (2020)
    Hindawi
    Details
    Publication Date: 2020-02-19
    Description: Frequency bifurcation phenomenon is an important input characteristic of the magnetically coupled resonant wireless power transfer (MCR-WPT) system in overcoupling situation. In this paper, frequency bifurcation phenomenon in MCR is extended to the general transmitter-receiver coupling system, and the two main factors affecting the phenomenon are analyzed. Finally, the phenomenon is introduced into the field of signal detection, and a noncontact detection method based on target coil resonance is proposed in this paper. Since the proposed method is a kind of electromagnetic method, the detection system is highly susceptible to the surrounding metal conductors. Therefore, the detection performance of this method under three metal-environment conditions is analyzed, respectively. Simulations and experiments show that the metal barrier can weaken the detection because of the eddy current effect, but as long as the barrier does not completely isolate the two coils, the method still has strong penetrability. Besides, the metal plate placed parallel outside the transmitter has less influence on the detection when compared with the metal barrier, and the metal plate by the side of the transmitter can even enhance the detection effect. As a consequence, this method has strong stability in metal environment.
    Print ISSN: 1076-2787
    Electronic ISSN: 1099-0526
    Topics: Computer Science , Mathematics
    Published by Hindawi
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