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Digitale Medien

On dynamic relaxation (1967)

Cristescu, N. ; Mihăilescu, M.

Springer

Rheologica acta 6 (1967), S. 144-146

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ISSN: 1435-1528

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Physik

Notizen: Summary One discusses the mathematical conditions to be satisfied by the coefficients entering in a quasi-linear constitutive law which can describe the phenomenon of dynamic relaxation. In the relaxation period the plastic component of the strain increases though the stress and the elastic component decrease. In this paper only one-dimensional problems are considered.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01969165

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Magnetically-driven 2D cells organization on superparamagnetic micromagnets fabricated by laser direct writing (2020)

Paun, I. A. ; Mustaciosu, C. C. ; Mihailescu, M. ; [weitere]

Springer Nature

In: Scientific Reports. 2020; 10(1): 16418. Published 2020 Oct 02. doi: 10.1038/s41598-020-73414-4.

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Publikationsdatum: 2020-10-02

Beschreibung: We demonstrate a proof of concept for magnetically-driven 2D cells organization on superparamagnetic micromagnets fabricated by laser direct writing via two photon polymerization (LDW via TPP) of a photopolymerizable superparamagnetic composite. The composite consisted of a commercially available, biocompatible photopolymer (Ormocore) mixed with 4 mg/mL superparamagnetic nanoparticles (MNPs). The micromagnets were designed in the shape of squares with 70 µm lateral dimension. To minimize the role of topographical cues on the cellular attachment, we fabricated 2D microarrays similar with a chessboard: the superparamagnetic micromagnets alternated with non-magnetic areas of identical shape and lateral size as the micromagnets, made from Ormocore by LDW via TPP. The height difference between the superparamagnetic and non-magnetic areas was of ~ 6 µm. In the absence of a static magnetic field, MNPs-free fibroblasts attached uniformly on the entire 2D microarray, with no preference for the superparamagnetic or non-magnetic areas. Under a static magnetic field of 1.3 T, the fibroblasts attached exclusively on the superparamagnetic micromagnets, resulting a precise 2D cell organization on the chessboard-like microarray. The described method has significant potential for fabricating biocompatible micromagnets with well-defined geometries for building skin grafts adapted for optimum tissue integration, starting from single cell manipulation up to the engineering of whole tissues.

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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