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  • 2020-2022  (28)
  • 1980-1984  (263)
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  • 1
    Monograph available for loan
    Monograph available for loan
    Introduction to statistics for geographers and earth scientists (1984)
    London [u.a.] : Macmillan
    Details Availability
    Call number: O 6105
    Type of Medium: Monograph available for loan
    Pages: viii, 349 S. : graph. Darst.
    ISBN: 0333352750
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
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    The hawaii to tahiti shuttle experiment (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-02
    Description: The Shuttle Experiment conducted between Hawaii and Tahiti from January 1979 to June 1980 was designed to observe the changing equatorial ocean structure and circulation, to study the variations and interactions of the four major equatorial ocean currents, and to develop a scientific basis for their monitoring by simple observations of thermal structure and sea level. Preliminary analyses of the results show that the equatorial thermal structure remains intact during a normal year and that only the positions and intensities of the currents are subject to change. The water transport of the equatorial undercurrent varied from 25 x 10(6) cubic meters per second in January to 51 x 10(6) cubic meters per second in July, but also exhibited strong short-term pulsations. The equatorial surface flow responded strongly to the winds at periods of 1 month and longer. An array of drifter buoys in the equatoral countercurrent was subject to very little dispersion while traveling over 4500 kilometers in 4 months. Low-frequency fluctuations in the North Equatorial Countercurrent can be monitored by means of the difference in sea level between Fanning and Majuro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyrtki, K -- Firing, E -- Halpern, D -- Knox, R -- McNally, G J -- Patzert, W C -- Stroup, E D -- Taft, B A -- Williams, R -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):22-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17731223" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: Most mitochondrial proteins are encoded in the nucleus and are translated on free cytoplasmic ribosomes as larger precursors containing amino-terminal "leader" sequences, which are removed after the precursors are taken up by mitochondria. We have deduced the complete primary structure of the precursor of a human mitochondrial matrix enzyme, ornithine transcarbamylase (OTC), from the nucleotide sequence of cloned complementary DNA. The amino-terminal leader peptide of OTC is 32 amino acids in length and contains four arginines but no acidic residues. Cleavage of the leader peptide from the "mature" protein occurs between glutamine and asparagine residues. The sequence of mature human OTC resembles that of the subunits of both OTC and aspartate transcarbamylase from Escherichia coli. The biological activity of the cloned OTC complementary DNA was tested by joining it with SV40 (an animal virus) regulatory elements and transfecting cultured HeLa cells, which do not normally express OTC. Both the precursor and mature forms of the OTC subunit were identified; in stable transformants, enzymatic activity was also detected.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horwich, A L -- Fenton, W A -- Williams, K R -- Kalousek, F -- Kraus, J P -- Doolittle, R F -- Konigsberg, W -- Rosenberg, L E -- AM 09527/AM/NIADDK NIH HHS/ -- AM 12579/AM/NIADDK NIH HHS/ -- GM 31539/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1068-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6372096" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cloning, Molecular ; DNA/genetics ; DNA, Mitochondrial/*genetics ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; HeLa Cells/metabolism ; Humans ; Mitochondria/enzymology ; Ornithine Carbamoyltransferase/*genetics ; Protein Biosynthesis ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    X-ray induction of persistent hypersensitivity to mutation (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-16
    Description: The progeny of x-irradiated V79 cells are hypersensitive to PUVA-(8-methoxypsoralen plus longwave ultraviolet light) induced mutation at the locus for hypoxanthine-guanine phosphoribosyl transferase. This hypersensitivity is most evident at low doses of pUVA that do not induce mutation in non-x-irradiated cells. The hypersensitivity is evoked by x-irradiation delivered as a single dose or as multiple fractions over a long period and persists for at least 108 days of exponential growth. This radiation-induced hypersensitivity to subsequent mutation is a new phenomenon that may be relevant to multistage carcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frank, J P -- Williams, J R -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):307-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063888" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured/*radiation effects ; Dose-Response Relationship, Radiation ; Hypoxanthine Phosphoribosyltransferase/genetics ; Mutation/*radiation effects ; PUVA Therapy/*adverse effects ; Photochemotherapy/*adverse effects ; *Radiation, Ionizing ; *X-Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-07
    Description: Complete neonatal thymectomy reduced the frequency of spontaneous diabetes mellitus in BioBreeding/Worcester rats from 27 to 3 percent. Incomplete thymectomy also significantly reduced the frequency of diabetes (to 9 percent). These findings strengthen the hypothesis that thymus-dependent, cell-mediated autoimmune destruction of pancreatic B cells is responsible for the pathogenesis of diabetes in this experimental animal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Like, A A -- Kislauskis, E -- Williams, R R -- Rossini, A A -- AM 19155/AM/NIADDK NIH HHS/ -- AM 25306/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 7;216(4546):644-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7041259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Mellitus, Experimental/genetics/*immunology/prevention & control ; Immunity, Cellular ; Islets of Langerhans/immunology ; Rats ; Rats, Mutant Strains/*physiology ; Thymectomy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Consequences of spatial sampling by a human photoreceptor mosaic (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-22
    Description: The short wavelength color mechanism in the human visual system can distinguish gratings from uniform fields of the same average radiance at spatial frequencies that are twice as high as the highest at which it can resolve bars in the grating. This discrimination above the resolution limit is associated with a splotchy or mottled appearance of the grating similar to two-dimensional noise. The most plausible explanation for the mottled pattern is that it is a moire pattern produced by aliasing (spatial undersampling) by an irregular and sparse mosaic of short wavelength cones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, D R -- Collier, R -- EY 01319/EY/NEI NIH HHS/ -- EY 04367/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):385-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867717" target="_blank"〉PubMed〈/a〉
    Keywords: Color Perception/physiology ; Humans ; Light ; Photoreceptor Cells/*physiology ; Retina/physiology ; Vision, Ocular/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-10-20
    Description: Although electrospun nanofibers are expanding their potential commercial applications in various fields, the issue of energy savings, which are important for cost reduction and technological feasibility, has received little attention to date. In this study, a concentric spinneret with a solid Teflon-core rod was developed to implement an energy-saving electrospinning process. Ketoprofen and polyvinylpyrrolidone (PVP) were used as a model of a poorly water-soluble drug and a filament-forming matrix, respectively, to obtain nanofibrous films via traditional tube-based electrospinning and the proposed solid rod-based electrospinning method. The functional performances of the films were compared through in vitro drug dissolution experiments and ex vivo sublingual drug permeation tests. Results demonstrated that both types of nanofibrous films do not significantly differ in terms of medical applications. However, the new process required only 53.9% of the energy consumed by the traditional method. This achievement was realized by the introduction of several engineering improvements based on applied surface modifications, such as a less energy dispersive air-epoxy resin surface of the spinneret, a free liquid guiding without backward capillary force of the Teflon-core rod, and a smaller fluid–Teflon adhesive force. Other non-conductive materials could be explored to develop new spinnerets offering good engineering control and energy savings to obtain low-cost electrospun polymeric nanofibers.
    Electronic ISSN: 2073-4360
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 8
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    Injectables and Depots to Prolong Drug Action of Proteins and Peptides (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-10-21
    Description: Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.
    Electronic ISSN: 1999-4923
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 9
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    Relationship between the water levels and the fish catches in lakes Mweru and Mweru wa Ntipa, Zambia (2021)
    In:  http://aquaticcommons.org/id/eprint/20537 | 4230 | 2016-04-23 16:40:28 | 20537 | National Fisheries Resources Research Institute, Uganda
    Details
    Publication Date: 2021-07-10
    Description: The relationships between water level and catch per effort in two Zambian lakes are compared. In the relatively stable Lake Mweru, a positive correlation exists which can be used, with certain reservations, to predict the stateof the fishery two years in advance. The cause of the relationship is probably the effect of water level on the marshy and swampy breeding areas, where at least the most common species in the commercial catch (Tilapia macruchir) has definite limits for the depth of water in which itwill breed. For Mweru wa Ntipa, a consistant definite relationship does not exist, probably because the water level and extent of the lake fluctuate widely.
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 21-32
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  • 10
    Electronic Resource
    Electronic Resource
    Pressure enhancement of charge-transfer complexing of 1-methyl-3-(carbomethoxy)pyridinium cation and 8-chlorotheophyllinate anion in aqueous solution (1981)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 85 (1981), S. 1795-1799 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150613a007
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    Paper (German National Licenses)
    Fulltext
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