Publication Date:
1984-03-30
Description:
Type I diabetes may be an autoimmune disorder, although the evidence is largely circumstantial. The natural history of the disease after diagnosis includes partial remission in most patients, but only about 3 percent achieve transient insulin independence. beta Cell function, as indicated by the plasma concentration of C-peptide, is lost over 6 to 30 months and islet cell antibodies disappeared over 1 to 2 years. This article describes a pilot study in which 41 patients were treated with the immunosuppressive agent cyclosporine for 2 to 12 months. Of 30 patients treated within 6 weeks of diagnosis, 16 became insulin independent with concentrations of plasma C-peptide in the normal range and decreasing titers of islet cell antibodies. Of 11 patients who entered the study 8 to 44 weeks after diagnosis, two achieved this state. These results indicate that a controlled trial of the effects of cyclosporine in type I diabetes should be conducted.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stiller, C R -- Dupre, J -- Gent, M -- Jenner, M R -- Keown, P A -- Laupacis, A -- Martell, R -- Rodger, N W -- von Graffenried, B -- Wolfe, B M -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1362-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6367043" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adult
;
Autoantibodies/analysis
;
C-Peptide/blood
;
Child
;
Creatinine/blood
;
Cyclosporins/adverse effects/*therapeutic use
;
Diabetes Mellitus, Type 1/*drug therapy/immunology
;
Female
;
Gingival Hyperplasia/chemically induced
;
Humans
;
Hypertrichosis/chemically induced
;
Insulin/therapeutic use
;
Islets of Langerhans/immunology
;
Kidney/drug effects
;
Male
;
Middle Aged
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
