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  • Animals  (2)
  • Cat  (2)
  • genetic variation  (2)
  • 2020-2022
  • 1980-1984  (6)
  • 1920-1924
  • 1
    Digitale Medien
    Digitale Medien
    Genetics of insect hemolymph β-N-acetylglucosaminidase in the silkworm, Bombyx mori (1981)
    Springer
    Biochemical genetics 19 (1981), S. 1-14 
    Details
    ISSN: 1573-4927
    Schlagwort(e): silkworm ; hemolymph β-N-acetylglucosaminidase ; genetic variation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The distribution of insect hemolymph β-N-acetylglucosaminidase was investigated in the silkworm, Bombyx mori. Activity in 115 varieties was 6.92±3.22 units/ml, ranging from 1.4 to 17.0 units/ml. No enzyme-deficient individuals were observed. By selecting individuals showing either high or low enzyme activities, homozygotes were separated with activities varying 10-fold between isolates. No differences in activity of α-mannosidase and β-galactosidase were observed. Thus, it appears that high- or low-enzyme silkworms (High or Low lines) shared the same genetic background except for the gene concerning the activity of β-N-acetylglucosaminidase. Studies on the heredity of the enzyme indicated that the synthesis of the enzyme protein was controlled by an autosomal allele. Examination by immunotitration and CM52-cellulose column chromatography revealed that the difference in activity between High and Low lines was due to the amount of the active enzyme, but not to an endogeneous activator or inhibitor. Furthermore, there was no isozymic difference in β-N-acetylglucosaminidase. Slab gel electrophoresis on polyacrylamide showed a species of enzyme (A) that stained more intensely in the High line. For the second species of enzyme (B), the converse was true. This evidence suggests that enzyme levels in hemolymph are under the control of a gene affording association of enzyme subunits to the active enzyme molecule.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00486133
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Genetics of insect hemolymph α-mannosidase in the silkworm, Bombyx mori (1983)
    Springer
    Biochemical genetics 21 (1983), S. 713-724 
    Details
    ISSN: 1573-4927
    Schlagwort(e): insect α-mannosidase ; genetic variation ; enzymic characterization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The genetics of hemolymph α-mannosidase was investigated in the silkworm, Bombyx mori. By selecting individuals showing either high or low enzyme activities, homozygotes were separated, with activities varying about five-fold. No differences in the activities of β-galactosidase and β-N-acetylglucosaminidase were observed. Thus, it seems that high- and low-enzyme silkworms (High and Low lines) share the same genetic background except for the gene concerning the activity of α-mannosidase. The synthesis of the enzyme is controlled by an autosomal allele. Furthermore, expression of the gene varies from tissue to tissue, and there is no correlation between enzyme activity and growth rate. The difference in activity between High and Low lines is due to the amount of active enzyme, not to an endogeneous activator or inhibitor. There was no isozymic difference in α-mannosidase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00498918
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Immunohistochemical demonstration of the distribution of serotonin neurons in the brainstem of the rat and cat (1982)
    Springer
    Cell & tissue research 224 (1982), S. 247-267 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Serotonin ; Brainstem ; Immunohistochemistry ; Rat ; Cat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The morphological characteristics and distribution of the somata of serotonin-containing neurons in the brainstem of rats and cats were studied by use of the peroxidase-anti peroxidase (PAP) immunohistochemical method employing highly specific antibodies to serotonin. Antibodies were raised in rabbits against an antigen prepared by coupling serotonin to bovine thyroglobulin and using formaldehyde as the coupling reagent. The distribution pattern of serotonin neurons observed in the present material is essentially in agreement with that described by other investigators who used the Falck-Hillarp method. In addition, this immunohistochemical technique revealed serotonin-containing perikarya in the following regions: 1) the periaqueductal gray, especially lateral to the nucleus raphe dorsalis, 2) the nucleus interpeduncularis, 3) the nucleus parabrachialis ventralis and dorsalis, 4) the field of the lemniscus lateralis, and 5) the reticular formation of the pons and medulla oblongata. The described immunohistochemical procedure makes it possible to study central serotonin neurons in detail without pharmacological pretreatment. The wide distribution of serotonin neurons demonstrated in this study should be considered when interpreting experiments dealing with the serotonin system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00216872
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Immunohistochemical demonstration of serotonin-containing nerve fibers in the cerebellum (1982)
    Springer
    Cell & tissue research 226 (1982), S. 1-12 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Serotonin-immunoreactive nerve fibers ; Cerebellum ; Cat ; Rat ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The localization of serotonin (5-HT)-immunoreactive nerve fibers in the cerebellum of the rat and cat was investigated by means of the peroxidase-anti-peroxidase (PAP) method using highly specific antibodies to 5-HT. Serotonin-containing nerve fibers were distributed throughout the entire cerebellum including the deep cerebellar nuclei, while 5-HT-positive neuronal somata were not detected in the cerebellum of either species. A different pattern of 5-HT innervation was found among the three layers of the cerebellar cortex. There were also interspecific differences in the pattern of distribution of 5-HT. In the rat, the pool of 5-HT nerve fibers mainly consisted of tangential elements, which were predominant in the molecular layer, while in the cat only a few 5-HT fibers were found in the molecular layer of the cerebellar cortex; dense networks of 5-HT nerve fibers were present in the granular layer. Some differences are evident in the pattern of distribution of 5-HT fibers in cerebellar regions classified on an anatomical and functional basis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00217077
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    facet.materialart.
    Unbekannt
    An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-06-27
    Beschreibung: A protein that may be an enkephalin precursor has been identified in extracts of bovine adrenal medulla. This protein (about 50,000 daltons) appears to contain seven copies of [Met]enkephalin and one copy of [Leu]enkephalin. Digestion with trypsin and carboxypeptidase B yields [Met]enkephalin and [Leu]enkephalin in a ratio of almost 7 to 1. The enkephalins were identified by chromatography and by their binding to opiate receptors. Some characteristics of several other adrenal peptides that may serve as intermediates in the biosynthesis of the enkephalins are presented.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewis, R V -- Stern, A S -- Kimura, S -- Rossier, J -- Stein, S -- Udenfriend, S -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384787" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenal Medulla/*analysis ; Animals ; Cattle ; Chromaffin Granules/*analysis ; Chromaffin System/*analysis ; Endorphins/*biosynthesis ; Enkephalin, Leucine ; Enkephalin, Methionine ; Enkephalins/*biosynthesis ; Molecular Weight ; Oligopeptides/analysis ; Peptide Fragments/analysis ; Protein Precursors/*analysis ; Proteins/*analysis ; Trypsin
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    facet.materialart.
    Unbekannt
    Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-05-30
    Beschreibung: Choline acetyltransferase was demonstrated in neuronal structures of the rodent central nervous system by immunohistochemistry through the application of Fab fragments obtained from monospecific antiserums to human choline acetyltransferase. The specificity of the antiserum for the enzyme was confirmed by the staining of both the ventral horn motor neurons in the rat spinal cord and the neuromuscular junction of the guinea pig diaphragm. Enzyme-containing cell bodies were observed in frontal sections of rat and guinea pig brain in the neostriatum, accumbens, nucleus of the diagonal band, medial septum, and olfactory tubercle. Positively staining fibers and probable nerve terminals were also found in the olfactory tubercle field and other areas of the basal forebrain. The results provide information on the distribution of the cholinergic systems in the rostral forebrain of the rodent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kimura, H -- McGeer, P L -- Peng, F -- McGeer, E G -- New York, N.Y. -- Science. 1980 May 30;208(4447):1057-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6990490" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/cytology/*enzymology ; Brain Mapping ; Choline O-Acetyltransferase/*metabolism ; Cholinergic Fibers/cytology ; Corpus Striatum/enzymology ; Guinea Pigs ; Hippocampus/enzymology ; Immunoenzyme Techniques ; Nucleus Accumbens/enzymology ; Olfactory Bulb/enzymology ; Rats ; Spinal Cord/enzymology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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