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  • 1
    Publication Date: 1987-05-01
    Description: GAP-43 is one of a small subset of cellular proteins selectively transported by a neuron to its terminals. Its enrichment in growth cones and its increased levels in developing or regenerating neurons suggest that it has an important role in neurite growth. A complementary DNA (cDNA) that encodes rat GAP-43 has been isolated to study its structural characteristics and regulation. The predicted molecular size is 24 kilodaltons, although its migration in SDS-polyacrylamide gels is anomalously retarded. Expression of GAP-43 is limited to the nervous system, where its levels are highest during periods of neurite outgrowth. Nerve growth factor or adenosine 3',5'-monophosphate induction of neurites from PC12 cells is accompanied by increased GAP-43 expression. GAP-43 RNA is easily detectable, although at diminished levels, in the adult rat nervous system. This regulation of GAP-43 is concordant with a role in growth-related processes of the neuron, processes that may continue in the mature animal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karns, L R -- Ng, S C -- Freeman, J A -- Fishman, M C -- New York, N.Y. -- Science. 1987 May 1;236(4801):597-600.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2437653" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Axons/physiology ; Bacteriophage lambda/genetics ; Base Sequence ; *Cloning, Molecular ; DNA/*genetics ; Electrophoresis, Polyacrylamide Gel ; GAP-43 Protein ; Ganglia, Spinal/analysis/embryology ; Gene Expression Regulation ; Growth Substances/genetics ; Immunosorbent Techniques ; Membrane Proteins/*genetics ; Nerve Tissue Proteins/*genetics ; Protein Biosynthesis ; RNA/genetics ; RNA, Messenger/genetics ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 2898-2900 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The photoion–photoelectron coincidence spectra for C2H+ and C2H+2 have been measured in the wavelength range of 645–765 A(ring). The C2H+2(A˜ 2Ag,B˜ 2∑+u) ions prepared with internal energies above 17.39 eV are found to dissociate completely into C2H++H in the temporal range 〈12 μs. An upper bound of 17.33±0.05 eV is determined for the appearance energy of the process C2H2+hν→C2H++H+e− at 0 K.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 4689-4696 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The photoion–photoelectron coincidence (PIPECO) spectra for Kr+2 and Xe+2 in the wavelength regions of 825–970 and 900–1030 A(ring), respectively, have been measured at different nozzle temperatures and stagnation pressures (P0). The ionization energies (IE) for Kr2 and Xe2 to Kr+2[I(1/2)u] and Xe+2[I(1/2)u] determined by the PIPECO spectra are in excellent agreement with the results of previous photoionization experiments. The PIPECO measurements for Kr+2 and Xe+2 also provide lower limits for the IEs of Kr2 and Xe2 to Kr+2[II(1/2)u] and Xe+2[II(1/2)u]. The PIPECO spectra for Kr+2 and Xe+2 display strong autoionization structures similar to those resolved in the corresponding photoionization efficiency spectra, indicating that a significant fraction of autoionizing electrons are slow electrons with near zero kinetic energies. The extreme weakness of the Kr+2[II(1/2)u] andXe+2[II(1/2)u] PIPECO bands observed at low P0 support the conclusion that excited Kr+2[II(1/2)u] and Xe+2[II(1/2)u] ions are dissociative with dissociation lifetimes shorter than 68 and 85 μs, respectively. These values are in accord with the calculated radiative lifetimes for the II(1/2)u→I(1/2)g transitions in Kr+2 and Xe+2. The intensities for the II(1/2)u PIPECO bands relative to the I(1/2)u and I(3/2)g PIPECO bands for Kr+2 and Xe+2 are found to increase as P0 is increased, an observation attributed to the formation of Kr+2 and Xe+2 from fragmentation of excited Kr+n and Xe+n ions produced in the photoionization of Krn and Xen, n≥3. The fragmentation of excited Kr+n and Xe+n , n≥3, ions have the effect of lowering the appearance energies for the Kr+2[II(1/2)u] and Xe+2[II(1/2)u] PIPECO bands.
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 2995-3003 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Photoion–photoelectron coincidence (PIPECO) spectra for Ar+n (n=2–4) in the wavelength region of 750–875 A(ring) have been measured at different nozzle stagnation pressures. The ionization energies (IE) for the ground Ar+2[I(1/2)u] and Ar+3[I(1/2)u] states are determined to be 14.518±0.017 eV (854±1 A(ring)) and 14.350±0.033 eV (864±2 A(ring)), in agreement with the findings of previous photoionization experiments. The IE for Ar+2[II(1/2)u] is found to be (approximately-less-than)15.83 eV (783 A(ring)). The observation of the Ar+2[II(1/2)u] PIPECO band supports the interpretation that Ar+2[II(1/2)u] is metastable with a lifetime longer than 47 μs, a value in accord with the calculated radiative lifetime of 90.9 μs for the II(1/2)u →I(1/2)g transition. The PIPECO spectrum for Ar+2 is dominated by autoionization structure similar to that resolved in the photoionization efficiency spectrum for Ar+2, indicating that a significant fraction of electrons produced by these autoionizing states are slow electrons with near-zero kinetic energies. Evidence is found that metastable Ar+3 and Ar+4 ions formed by photoionization of Ar3 and Ar4 at energies above the Ar+2[I(1/2)u]+Ar(1S0) and Ar+3[I(1/2)u]+Ar(1S0) dissociation limits may live longer than 58 and 66 μs, respectively. We suggest that the formation of Ar+3 in metastable electronic states may be responsible for the long dissociation lifetimes of Ar+3 observed in this experiment.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 6026-6033 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The photoion–photoelectron coincidence (PIPECO) spectra for (CO)+2 in the wavelength region of 620–990 A(ring) have been obtained at different nozzle stagnation pressures (P0). The ionization energy for (CO)2 to CO+(X˜)⋅CO is determined to be (approximately-less-than)12.73±0.05 eV (974±4 A(ring)), indicating that CO+(X˜)⋅CO is bound by more than 1.29 eV. The PIPECO measurements also provide evidence that CO+(A˜,B˜)⋅CO are bound with dissociation energies 〉0.3 eV. At P0≤200 Torr and a nozzle temperature (T) of 120 K, nozzle expansion conditions which minimize the formation of (CO)n (n≥3), the intensities for the CO+(A˜,B˜)⋅CO PIPECO bands are found to be negligibly small compared to that for the CO+(X˜)⋅CO PIPECO band. This observation supports the conclusion that the excited CO+(A˜,B˜)⋅CO ions are dissociative, with dissociation lifetimes〈42 μs. This conclusion is contrary to that of the preliminary study which is based on the PIPECO spectrum for (CO)+2 measured at P0=350 Torr and T=120 K. Assuming that the radiative lifetimes of CO+(A˜ or B˜) and CO+(A˜ or B˜)⋅CO are identical, we estimate that the dissociation lifetimes for CO+(A˜)⋅CO and CO+(B˜)⋅CO are (approximately-less-than)4 μs and (approximately-less-than)50 ns, respectively.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 849-856 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The photoion–photoelectron coincidence (PIPECO) spectra for (N2)+2 in the wavelength range 650–866 A(ring) have been measured at different nozzle stagnation pressures. The formation of stable (N2)+2 from fragmentation of excited (N2)+n cluster ions initially produced by photoionization of (N2)n, n≥3, is efficient. For nozzle expansion conditions which minimize the production of (N2)n, n≥3, the intensities for the N+2(A˜,B˜)⋅N2 PIPECO bands are found to be negligibly small compared to that of the N+2(X˜)⋅N2 PIPECO band, indicating that the electronically excited N+2(A˜,B˜)⋅N2 dimer ions are dissociative in temporal ranges 〈42 μs. Assuming that the radiative lifetimes for N+2(A˜,B˜) and N+2(A˜,B˜)⋅N2 are identical, we estimate that the dissociative lifetimes for N+2(A˜)⋅N2 and N+2(B˜)⋅N2 are (approximately-less-than)10 μs and (approximately-less-than)60 ns, respectively. The ionization energy for (N2)2 is determined to be 14.50±0.08 eV (855±5 A(ring)), suggesting that N+2(X˜)⋅N2 is bound by 1.09±0.08 eV. The PIPECO data for (N2)+2 presented here and those for (CO)+2 reported previously support the perturbed monomer ion model for the photoionization of a van der Waals cluster. Namely, the formation of N+2⋅(N2)n−1 by photoionization of (N2)n, n≥2, can be viewed as a photoionization process of N2 perturbed by the presence of other N2 molecules in the clusters. We suggest that the rapid dissociation of electronically and vibrationally excited dimer ions is a general mechanism for the suppression of autoionization features in the photoionization efficiency spectrum for an ionized van der Waals dimer.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 3381-3382 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Absolute total cross sections for the formation of C+ , O+ , and ArC+ in the collisions of Ar+ (2 P3/2,1/2 )+CO have been measured over the center-of-mass collision energy (Ec.m. ) range of ∼4–123 eV. The observed appearance energies for C+ and O+ are in agreement with the thermochemical thresholds for the C+ (2 P)+O(3 P) and O+ (4 S0 )+C(3 P) product channels, respectively. The cross sections for C+ are significant compared to those for CO+ . At Ec.m. =12.9 eV, the analysis of the kinetic energy distributions of C+ and CO+ supports the conclusions that many excited vibronic states of CO+ are populated and that the C+ ions are formed by predissociation of electronic excited CO+ .
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 59 (1988), S. 342-346 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An inexpensive yet reliable and convenient Weiss extraction system involving a magnet of maximum field strength of 8.9 kOe and a signal collection system coupled to an Apple II computer is described. The data obtained using such a system for H2S and AsH3 adsorption on Ni/SiO2 catalysts are discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 535 (1988), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 4098-4099 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The photoion–photoelectron coincidence (PIPECO) spectrum for (CO)+2 has been measured in the wavelength region of ∼600–1 000 A(ring). The lower limits for the bond dissociation energies of CO+ (X˜)⋅CO, CO+ (A˜)⋅CO, and CO+ (B˜)⋅CO are determined to be 29.8, 17, and 16 kcal/mol, respectively. Evidence supporting the existence of long-lived (CO)+2 states with dissociation lifetimes 〉40 μs at energies above the CO+ (X˜,v=0)+CO asymptote is found. The dissociative lifetimes of CO+ (A˜)⋅CO and CO+(B˜)⋅CO are estimated to be longer than 4 μs and 50 ns, respectively.
    Type of Medium: Electronic Resource
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