ISSN:
1617-4623
Keywords:
Error-prone repair
;
Genetic duplication
;
Carcinogens
;
Mutagens
;
Recombination
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Selection for 3-amino-1,2,4-triazole (AT) resistance in certain strains of Salmonella typhimurium has been previously shown to select for genetic tandem duplications of the histidine operon. We show here that agents which induce tandem duplications are less effective in such induction in the presence of the pKM101 plasmid. The presence of the plasmid also produces an increase in AT-resistance due to mechanisms other than duplication, presumably because pKM101 produces high levels of error-prone repair. We suggest that high levels of error-prone repair may cause decreases in tandem duplication induction and propose that error-prone repair and tandem duplication may be alternative cellular responses to certain DNA lesions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00425510
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