ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

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Trends in short-term survival from distant-stage cutaneous melanoma in the United States, 2001-2013 (CONCORD-3) (2020)

Di Carlo, Veronica ; Estève, Jacques ; Johnson, Christopher ; [weitere]

Oxford University Press

In: JNCI Cancer Spectrum. 2020; Published 2020 Sep 14. doi: 10.1093/jncics/pkaa078. [early online release]

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Publikationsdatum: 2020-09-14

Beschreibung: Background Survival from metastatic cutaneous melanoma is substantially lower than for localised disease. Treatments for metastatic melanoma have been limited, but remarkable clinical improvements have been reported in clinical trials in the last decade. We described the characteristics of US patients diagnosed with cutaneous melanoma during 2001-2013 and assessed trends in short-term survival for distant-stage disease. Methods Trends in 1-year net survival were estimated using the Pohar Perme estimator, controlling for background mortality with life tables of all-cause mortality rates by county of residence, single year of age, sex and race for each year 2001-2013. We fitted a flexible parametric survival model on the log-hazard scale to estimate the effect of race on the hazard of death due to melanoma, and estimated 1-year net survival by race. Results Only 4.4% of the 425,915 melanomas were diagnosed at a distant stage, with higher proportions in men, older patients and African Americans. Age-standardised 1-year net survival for distant-stage disease was stable at around 43% during 2001-2010. From 2010 onwards, survival improved rapidly, reaching 58.9% (95% confidence interval [CI] = 56.6% to 61.2%) for patients diagnosed in 2013. Younger patients experienced the largest improvement. Survival for distant-stage disease increased in both Blacks and Whites, but was consistently lower in Blacks. Conclusions One-year survival for distant-stage melanoma improved during 2001-2013, particularly in younger patients and those diagnosed since 2010. This improvement may be a consequence of the introduction of immune-checkpoint-inhibitors and other targeted treatments for metastatic and unresectable disease. Persistent survival inequalities exist between Blacks and Whites, suggesting differential access to treatment.

Digitale ISSN: 2515-5091

Thema: Chemie und Pharmazie , Medizin

Publiziert von Oxford University Press im Namen von National Cancer Institute.

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2

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Abstracts of papers Minneapolis Fall Meeting (1963)

Litchfield, C. C. ; Rakoff, Henry ; Maire, Renȳ ; [weitere]

Wiley

In: Journal of the American Oil Chemists' Society. 1963; 40(9): 9-45. Published 1963 Sep 01. doi: 10.1007/bf02632851.

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Publikationsdatum: 1963-09-01

Print ISSN: 0003-021X

Digitale ISSN: 1558-9331

Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Publiziert von Wiley

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3

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Hayflick-NIH Settlement (1982)

B. L. Strehler ; S. Abraham ; K. Bayreuther ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 215(4530): 240-2. doi: 10.1126/science.215.4530.240-b.

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Publikationsdatum: 1982-01-15

Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strehler, B L -- Abraham, S -- Bayreuther, K -- Bienenstock, A -- Binstock, R -- Birren, J -- Blumenthal, H T -- Brautbar, C -- Brody, E M -- Brody, H -- Comfort, A -- Cottle, R W -- Danielli, J F -- Danon, D -- Datan, N -- Ebbesen, P -- Elsen, A -- Freundt, E A -- Gallop, P M -- Girardi, A J -- Glenn, P F -- Goheen, J D -- Goldstein, S -- Good, R A -- Goodlin, R C -- Granoff, A -- Gray, A -- Haber, P A -- Hamparian, V V -- Hijmans, W -- Holliday, R -- Horvath, S M -- Houck, J C -- Huebner, R J -- Itoh, H -- Jukes, T -- Kaplan, H S -- Kirkman, H -- Kuwert, E -- Leiderman, P H -- Liss, A -- Litwin, J -- Lubin, B -- Macieira-Coelho, A -- Madoff, S -- Maletta, G J -- Maramorosch, K -- Martin, G M -- Masover, G -- Matsumura, T -- Medvedev, Z -- Melnick, J L -- Merchant, D J -- Namba, M -- Neter, E -- Neugarten, B -- Orgel, L -- Outschoorn, A S -- Pace, D M -- Packer, L -- Parker, J C -- Patterson, M D Jr -- Pollard, M -- Portnuff, J -- Razin, S -- Reiff, T R -- Robert, L -- Rockstein, M -- Rosamoff, H -- Rosanoff, E I -- Rottem, S -- Schachter, J -- Schwartz, H -- Shanas, E -- Shimkin, M B -- Smith, J R -- Somerson, N L -- Stinebring, W -- Textor, R -- Thomas, L -- Viidik, A -- Weg, R -- Yabrov, A -- Yanofsky, C -- Zatz, L M -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):240-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17784330" target="_blank"〉PubMed〈/a〉

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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4

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The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents (2020)

Villas-Boas, Gustavo R. ; Rescia, Vanessa C. ; Paes, Marina M. ; [weitere]

Molecular Diversity Preservation International

In: Molecules. 2020; 25(18): 4086. Published 2020 Sep 07. doi: 10.3390/molecules25184086.

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Publikationsdatum: 2020-09-07

Beschreibung: On March 11, 2020, the World Health Organization (WHO) officially declared the outbreak caused by the new coronavirus (SARS-CoV-2) a pandemic. The rapid spread of the disease surprised the scientific and medical community. Based on the latest reports, news, and scientific articles published, there is no doubt that the coronavirus has overloaded health systems globally. Practical actions against the recent emergence and rapid expansion of the SARS-CoV-2 require the development and use of tools for discovering new molecular anti-SARS-CoV-2 targets. Thus, this review presents bioinformatics and molecular modeling strategies that aim to assist in the discovery of potential anti-SARS-CoV-2 agents. Besides, we reviewed the relationship between SARS-CoV-2 and innate immunity, since understanding the structures involved in this infection can contribute to the development of new therapeutic targets. Bioinformatics is a technology that assists researchers in coping with diseases by investigating genetic sequencing and seeking structural models of potential molecular targets present in SARS-CoV2. The details provided in this review provide future points of consideration in the field of virology and medical sciences that will contribute to clarifying potential therapeutic targets for anti-SARS-CoV-2 and for understanding the molecular mechanisms responsible for the pathogenesis and virulence of SARS-CoV-2.

Digitale ISSN: 1420-3049

Thema: Chemie und Pharmazie

Publiziert von Molecular Diversity Preservation International

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5

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Supercomputer-Based Ensemble Docking Drug Discovery Pipeline with Application to Covid-19 (2020)

Acharya, A. ; Agarwal, R. ; Baker, M. B. ; [weitere]

American Chemical Society

In: Journal of Chemical Information and Modeling. 2020; 60(12): 5832-5852. Published 2020 Dec 16. doi: 10.1021/acs.jcim.0c01010.

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Publikationsdatum: 2020-12-16

Print ISSN: 1549-9596

Digitale ISSN: 1549-960X

Thema: Chemie und Pharmazie

Publiziert von American Chemical Society

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6

Digitale Medien

A new macromolecular crystallography Station (9.5) on the SRS wiggler beam line for very rapid Laue and rapidly tunable monochromatic measurements: Commissioning and first results : Proceedings of the 4th international conference on synchrotron radiation instrumentation (1992)

Thompson, A. W. ; Habash, J. ; Harrop, S. ; [weitere]

[S.l.] : American Institute of Physics (AIP)

Review of Scientific Instruments 63 (1992), S. 1062-1064

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ISSN: 1089-7623

Quelle: AIP Digital Archive

Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik

Notizen: A new instrument (Station 9.5) has been established on the wiggler line at the Daresbury Synchrotron Radiation Source (SRS). It extends the experimental capability at Daresbury for macromolecular crystallography beyond what is provided for with Stations 7.2 (Ref. 1), 9.6 (Ref. 2), and 9.7 by providing a point focused white beam (from a Pt-coated toroid mirror) and/or a rapidly tunable monochromatic beam (using a water-cooled double-crystal monochromator (Ref. 3). The design principles of the new Station 9.5 have been published (Ref. 4). A CCD detector for the station is being developed (preliminary work is described in Ref. 5, or see the additional poster at this meeting) to allow time slices of part of a diffraction pattern to be measured. Laue patterns are currently recorded on film, but access to an image plate detector will shortly become available. Shutter speeds down to 50 μs are routinely available using a rotating disk shutter (Ref. 6). Fluorescence detectors are available for optimized anomalous dispersion data collection. The experimental bench is long enough to accommodate a camera system, and downstream from it an "on-line'' image plate scanner. Data collected on the instrument in various modes of operation will be described for a variety of macro and small molecule crystal systems.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1063/1.1143199

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7

Digitale Medien

Triangulanes: stereoisomerism and general method of synthesis [Erratum to document cited in CA113(21):190797n] (1991)

Zefirov, N. S. ; Kozhushkov, S. I. ; Kuznetsova, T. S. ; [weitere]

s.l. : American Chemical Society

Journal of the American Chemical Society 113 (1991), S. 9901-9901

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ISSN: 1520-5126

Quelle: ACS Legacy Archives

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1021/ja00026a054

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Digitale Medien

Triangulanes: stereoisomerism and general method of synthesis (1990)

Zefirov, N. S. ; Kozhushkov, S. I. ; Kuznetsova, T. S. ; [weitere]

s.l. : American Chemical Society

Journal of the American Chemical Society 112 (1990), S. 7702-7707

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ISSN: 1520-5126

Quelle: ACS Legacy Archives

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1021/ja00177a034

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Synthesis of Samarium OxysulfateSm2O2SO4 in the High-Temperature Oxidation Reaction and Its Structural, Thermal and Luminescent Properties (2020)

Denisenko, Yu. G. ; Sal’nikova, E. I. ; Basova, S. A. ; [weitere]

Molecular Diversity Preservation International

In: Molecules. 2020; 25(6): 1330. Published 2020 Mar 14. doi: 10.3390/molecules25061330.

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Publikationsdatum: 2020-03-14

Beschreibung: The oxidation process of samariumoxysulfide was studied in the temperature range of 500–1000 °C. Our DTA investigation allowed for establishing the main thermodynamic (∆Hºexp = −654.6 kJ/mol) and kinetic characteristics of the process (Ea = 244 kJ/mol, A = 2 × 1010). The enthalpy value of samarium oxysulfate (ΔHºf (Sm2O2SO4(monocl)) = −2294.0 kJ/mol) formation was calculated. The calculated process enthalpy value coincides with the value determined in the experiment. It was established that samarium oxysulfate crystallizes in the monoclinic symmetry class and its crystal structure belongs to space group C2/c with unit cell parameters a = 13.7442 (2), b = 4.20178 (4) and c = 8.16711 (8)Å, β = 107.224 (1)°, V = 450.498 (9)Å3, Z = 4. The main elements of the crystalline structure are obtained and the cation coordination environment is analyzed in detail. Vibrational spectroscopy methods confirmed the structural model adequacy. The Sm2O2SO4luminescence spectra exhibit three main bands easily assignable to the transitions from 4G5/2 state to 6H5/2, 6H7/2, and 6H9/2 multiplets.

Digitale ISSN: 1420-3049

Thema: Chemie und Pharmazie

Publiziert von Molecular Diversity Preservation International

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Seismicity remotely triggered by the magnitude 7.3 landers, california, earthquake (1993)

D. P. Hill ; P. A. Reasenberg ; A. Michael ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 260(5114): 1617-23. doi: 10.1126/science.260.5114.1617.

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Publikationsdatum: 1993-06-11

Beschreibung: The magnitude 7.3 Landers earthquake of 28 June 1992 triggered a remarkably sudden and widespread increase in earthquake activity across much of the western United States. The triggered earthquakes, which occurred at distances up to 1250 kilometers (17 source dimensions) from the Landers mainshock, were confined to areas of persistent seismicity and strike-slip to normal faulting. Many of the triggered areas also are sites of geothermal and recent volcanic activity. Static stress changes calculated for elastic models of the earthquake appear to be too small to have caused the triggering. The most promising explanations involve nonlinear interactions between large dynamic strains accompanying seismic waves from the mainshock and crustal fluids (perhaps including crustal magma).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, D P -- Reasenberg, P A -- Michael, A -- Arabaz, W J -- Beroza, G -- Brumbaugh, D -- Brune, J N -- Castro, R -- Davis, S -- Depolo, D -- Ellsworth, W L -- Gomberg, J -- Harmsen, S -- House, L -- Jackson, S M -- Johnston, M J -- Jones, L -- Keller, R -- Malone, S -- Munguia, L -- Nava, S -- Pechmann, J C -- Sanford, A -- Simpson, R W -- Smith, R B -- Stark, M -- Stickney, M -- Vidal, A -- Walter, S -- Wong, V -- Zollweg, J -- New York, N.Y. -- Science. 1993 Jun 11;260(5114):1617-23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17810202" target="_blank"〉PubMed〈/a〉

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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