ISSN:
1572-896X
Keywords:
sparingly soluble drug
;
phenytoin
;
sol–gel process
;
silica–drug hybrids
;
hydrogen bond
;
dissolution rate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Physics
,
Technology
Notes:
Abstract A sparingly soluble model drug, phenytoin (5,5-diphenyl-hydantoin, denoted as PT), was incorporated during or after hydrolysis and polycondensation of tetra orthoethyl silicate (TEOS) to obtain silica–drug hybrids. We also compare the hybrids obtained by sol–gel process with those obtained by simple adsorption on nonporous silica particles. The initial rate of dissolution in water increases by a factor of 40 with respect to the intact PT by aging silica before drug addition. The IR results show that νC=O in the position 2 of PT and νN–H shift toward the higher wavenumber, showing that intermolecular hydrogen bonds between C=O and N–H are loosened or broken to form new hydrogen bonds between C=O in PT and Si–OH in silica. The dissolution rate of PT is determined by the degree of the breakage of hydrogen bonds between PT molecules and the intensity of the interaction between silica and PT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1010048332458
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