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  • Springer  (48)
  • American Association for the Advancement of Science (AAAS)  (5)
  • 2020-2022  (5)
  • 1995-1999  (48)
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  • 1
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    Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-11
    Description: Sickle cell anemia is the most common heritable hematological disease, yet no curative treatment exists for this disorder. Moreover, the intricacies of globin gene expression have made the development of treatments for hemoglobinopathies based on gene therapy difficult. An alternative genetic approach to sickle cell therapy is based on RNA repair. A trans-splicing group I ribozyme was used to alter mutant beta-globin transcripts in erythrocyte precursors derived from peripheral blood from individuals with sickle cell disease. Sickle beta-globin transcripts were converted into messenger RNAs encoding the anti-sickling protein gamma-globin. These results suggest that RNA repair may become a useful approach in the treatment of genetic disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lan, N -- Howrey, R P -- Lee, S W -- Smith, C A -- Sullenger, B A -- HL57606/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1998 Jun 5;280(5369):1593-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genetic and Cellular Therapies, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9616120" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*blood/therapy ; Cloning, Molecular ; Erythroid Precursor Cells/*metabolism ; Exons ; Fetal Blood ; Genetic Therapy ; Globins/*genetics ; Humans ; Mutation ; Polymerase Chain Reaction ; *RNA Splicing ; RNA, Catalytic/genetics/*metabolism ; RNA, Messenger/chemistry/*genetics/metabolism ; Transfection ; Uridine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reovirus therapy of tumors with activated Ras pathway (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-13
    Description: Human reovirus requires an activated Ras signaling pathway for infection of cultured cells. To investigate whether this property can be exploited for cancer therapy, severe combined immune deficient mice bearing tumors established from v-erbB-transformed murine NIH 3T3 cells or human U87 glioblastoma cells were treated with the virus. A single intratumoral injection of virus resulted in regression of tumors in 65 to 80 percent of the mice. Treatment of immune-competent C3H mice bearing tumors established from ras-transformed C3H-10T1/2 cells also resulted in tumor regression, although a series of injections were required. These results suggest that, with further work, reovirus may have applicability in the treatment of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coffey, M C -- Strong, J E -- Forsyth, P A -- Lee, P W -- New York, N.Y. -- Science. 1998 Nov 13;282(5392):1332-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Biology Research Group and Department of Microbiology and Infectious Diseases, University of Calgary Health Science Centre, Calgary, Alberta, T2N 4N1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9812900" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; Antibodies, Viral/immunology ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cell Line, Transformed ; Genes, erbB ; *Genes, ras ; Humans ; Male ; Mammalian orthoreovirus 3/immunology/*physiology ; Mice ; Mice, Inbred C3H ; Mice, SCID ; Neoplasm Transplantation ; Neoplasms, Experimental/metabolism/pathology/*therapy/virology ; Signal Transduction ; Tumor Cells, Cultured ; Virus Replication ; ras Proteins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Turbulent transport reduction by zonal flows: massively parallel simulations (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-09-22
    Description: Three-dimensional gyrokinetic simulations of microturbulence in magnetically confined toroidal plasmas with massively parallel computers showed that, with linear flow damping, an asymptotic residual flow develops in agreement with analytic calculations. Nonlinear global simulations of instabilities driven by temperature gradients in the ion component of the plasma support the view that turbulence-driven fluctuating zonal flows can substantially reduce turbulent transport. Finally, the outstanding differences in the flow dynamics observed in global and local simulations are found to be due to profile variations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin -- Hahm -- Lee -- Tang -- White -- New York, N.Y. -- Science. 1998 Sep 18;281(5384):1835-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Princeton Plasma Physics Laboratory, Princeton University, Post Office Box 451, Princeton, NJ 08543, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9743492" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-04
    Description: Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iwata, S -- Lee, J W -- Okada, K -- Lee, J K -- Iwata, M -- Rasmussen, B -- Link, T A -- Ramaswamy, S -- Jap, B K -- New York, N.Y. -- Science. 1998 Jul 3;281(5373):64-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA. iwata@xray.bmc.uu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9651245" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Cattle ; Crystallization ; Crystallography, X-Ray ; Cytochrome b Group/chemistry/metabolism ; Cytochromes c1/chemistry/metabolism ; Electron Transport ; Electron Transport Complex III/*chemistry/metabolism ; Enzyme Inhibitors/metabolism ; Hydrogen Bonding ; Hydroquinones/metabolism ; Intracellular Membranes/enzymology ; Iron-Sulfur Proteins/chemistry/metabolism ; Methacrylates ; Mitochondria, Heart/*enzymology ; Models, Molecular ; Molecular Sequence Data ; Oxidation-Reduction ; *Protein Conformation ; Protein Structure, Secondary ; Thiazoles/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Oxygenic Photoautotrophic Growth Without Photosystem I (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-07-19
    Description: Contrary to the prediction of the Z-scheme model of photosynthesis, experiments demonstrated that mutants of Chlamydomonas containing photosystem II (PSII) but lacking photosystem I (PSI) can grow photoautotrophically with O2 evolution, using atmospheric CO2 as the sole carbon source. Autotrophic photosynthesis by PSI-deficient mutants was stable both under anaerobic conditions and in air (21 percent O2) at an actinic intensity of 200 microeinsteins per square meter per second. This PSII photosynthesis, which was sufficient to support cell development and mobility, may also occur in wild-type green algae and higher plants. The mutants can survive under 2000 microeinsteins per square meter per second with air, although they have less resistance to photoinhibition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee -- Tevault -- Owens -- Greenbaum -- New York, N.Y. -- Science. 1996 Jul 19;273(5273):364-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉J. W. Lee, C. V. Tevault, E. Greenbaum, Chemical Technology Division, Oak Ridge National Laboratory, Post Office Box 2008, Oak Ridge, TN 37831-6194, USA. T. G. Owens, Section of Plant Biology, Cornell University, Ithaca, NY 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662525" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    Neural simulation of a prototype keyboard assembly cell with adaptive control (1996)
    Springer
    Journal of intelligent manufacturing 7 (1996), S. 379-386 
    Details
    ISSN: 1572-8145
    Keywords: Neural simulation ; keyboards ; SIMAN ; assembly ; control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper describes the integration of a feedforward neural network with a real-time adaptive control technique to model an assembly cell for computer keyboards. The simulation model is able to undertake real-time forecasting of the expected behaviour of the cell, and also able to display in real time the current status of the assembly cell. The potential of integrating artificial neural networks into simulation together with an on-line real-time interface between the simulation model and the real-world system is investigated in this study. A simulation model was built in SIMAN with a neural network written in NeuralWork Professional II Plus embedded in the model to allow training and testing of the network. The control of the cell was achieved through a third-party program written in C that interfaces directly to the cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00123914
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  • 7
    Electronic Resource
    Electronic Resource
    Electrochemical behaviour of a hydrogen/oxygen gas mixture at a solid polymer electrolyte interface (1998)
    Springer
    Journal of applied electrochemistry 28 (1998), S. 1413-1418 
    Details
    ISSN: 1572-8838
    Keywords: energy conversion ; hydrogen purification ; hydrogen/oxygen gas mixture ; PEMFC ; solid polymer electrolyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The electrochemical behaviour of a hydrogen/oxygen gas mixture at platinum electrodes in contact with a solid polymer electrolyte (Nafion 115) was studied in two modes: hydrogen enrichment and fuel cell. In the hydrogen enrichment (purification) mode, i/V(V being the applied voltage) characteristics were identified for the electrochemical cell arranged so that the gas mixture with varying ratios which contacts the anode was purified to pure hydrogen gas that was released at the cathode. In the fuel cell mode, V/i (V being the terminal voltage) characteristics were determined for the cell which utilized the gas mixture with varying ratio at the anode and pure oxygen at the cathode. The effect of the decrease in the mole fraction of hydrogen (χH2) on the current density or the terminal voltage was particularly severe for χH2〈0.6. The drop was analysed employing terms such as oxygen reduction current, oxygen adsorption and the change of e.m.f. (electromotive force) due to the decrease in the partial pressure of the hydrogen gas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003439925193
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  • 8
    Electronic Resource
    Electronic Resource
    In Vivo Estrogenic Action of Nonylphenol in Immature Female Rats (1996)
    Springer
    Bulletin of environmental contamination and toxicology 57 (1996), S. 341 -348 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900196
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  • 9
    Electronic Resource
    Electronic Resource
    Creating executable models of influence nets with colored Petri nets (1998)
    Springer
    International journal on software tools for technology transfer 2 (1998), S. 168-181 
    Details
    ISSN: 1433-2787
    Keywords: Key words: High-level Petri nets – Colored Petri nets – Influence nets – Bayesian nets – Course of action – Discrete event dynamical systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100090050025
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  • 10
    Electronic Resource
    Electronic Resource
    Heat (mass) transfer between an impinging jet and a rotating disk (1998)
    Springer
    Heat and mass transfer 34 (1998), S. 195-201 
    Details
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The aim of this experimental study is to investigate the heat (mass) transfer of a rotating disk with an impinging circular jet. To facilitate the experiments, the naphthalene sublimation technique was employed. In order to analyze the results, measurements of the heat (mass) transfer of a stationary disk with an impinging jet and a rotating disk without jet impingement were also made. From the experimental results, it is found that the heat (mass) transfer are precisely divided into three regimes, namely the impingement dominated regime; the mixed regime and the rotation dominated regime. Correlation of Sherwood number of a rotating disk with jet impingement is also proposed in the present work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002310050249
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