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  • Analytical Chemistry and Spectroscopy  (3)
  • Wiley-Blackwell  (3)
  • American Institute of Physics (AIP)
  • Springer
  • 2020-2022
  • 1995-1999  (3)
  • 1975-1979
Collection
Keywords
Publisher
  • Wiley-Blackwell  (3)
  • American Institute of Physics (AIP)
  • Springer
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Modified ionspray interface for supercritical fluid chromatography/mass spectrometry: Interface design and initial results (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1087-1094 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A pneumatically assisted electrospray liquid chromatography/mass spectrometry interface has been modified for use with open-tubular supercritical fluid chromatography (SFC). The modified interface houses the SFC flow restrictor within the spray device. A sheath-flow liquid of methanol or methanol/water containing ammonium acetate flows coaxially to the restrictor. The addition of the sheath-flow liquid results in the ionization of analytes known to be in a neutral charge state during the chromatographic separation. The sheath-flow liquid also allows for the independent operation of the chromatograph and the mass spectrometer. Both could be operated under optimum conditions. The operation of the interface was optimized using a solution of poly(dimethylsiloxane) in CO2 introduced by continuous infusion. We also report the application of the modified instrument to samples containing amines and propoxylated alcohols.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290091202
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  • 2
    Electronic Resource
    Electronic Resource
    Development and application of a gas chromatographic/mass spectrometric/mass spectrometric method for the determination of 5-methoxyflavone in rat and dog plasma (1995)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 30 (1995), S. 438-445 
    Details
    ISSN: 1076-5174
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A gas chromatographic/mass spectrometric/mass spectrometric method was developed for the determination of 5-methoxyflavone in plasma. Optimized detection schemes for 5-methoxyflavone readily allow a limit of quantification of 1 ng ml-1 in rat or dog plasma (1.0 ml sample volume). The complete analysis time (injection to injection) is less than 9 min and allows for rapid automated sample throughput. Additional advantages include a high degree of specifity and good accuracy and precision. This type of rapid tandem mass spectrometric assay has been found to be particularly useful in pharmaceutical discovery, since an assay for one compound can be quickly developed, utilized and then modified to determine analogs of similar structure. Application of this methodology to pilot preclinical pharmacokinetic studies of the drug indicated that it is rapidly absorbed and cleared, with an apparent terminal half-life of about 15 min in dogs. Bioavailability in the two dogs tested ranged 33 to 72%, but was about 25% in rats.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jms.1190300307
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  • 3
    Electronic Resource
    Electronic Resource
    Raman, infrared and 13C NMR studies of mixed halides of cyclopropene, C3ClnBr4 - n, and cyclopropane, C3ClnBr6 - n (1995)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 26 (1995), S. 595-599 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Tetrachlorocyclopropene, C3Cl4, is converted into C3Br4 by treatment with BBr3. Use of less than the stoichiometric amount of BBr3 leads to mixed halides C3ClnBr4-n which are identified and investigated by Raman and 13C NMR spectroscopy. The addition of Br2 to C3Cl4 yields both the isomers cis- and trans-1,2-dibromotetrachlorocyclopropane in equal quantities; the vibrational spectra are reported and partially assigned. Raman and 13C NMR of other mixed halides of cyclopropane, C3ClnBr6-n are discussed. A 35Cl/37Cl isotope effect is detected on the carbon chemical shift of C3Cl6 I2 fails to react with C3Cl4 or C3Br4.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250260803
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