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Digitale Medien

Synthesis of gadolinium oxide magnetoliposomes for magnetic resonance imaging (2000)

Roberts, Danielle ; Zhu, Weibe L. ; Frommen, Christoph M. ; [weitere]

[S.l.] : American Institute of Physics (AIP)

Journal of Applied Physics 87 (2000), S. 6208-6210

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ISSN: 1089-7550

Quelle: AIP Digital Archive

Thema: Physik

Notizen: A method for the synthesis of gadolinium oxide magnetoliposomes, i.e., nanosized gadolinium oxide magnetic particles coated by a phospholipid membrane, is presented. Magnetoliposomes were prepared by reacting lauric acid coated gadolinium oxide nanoparticles with dimyristoylphosphatidylcholine liposomes prepared using a direct injection method. The gadolinium oxide magnetoliposomes were characterized using transmission electron microscopy imaging, x-ray diffraction, and fluorescence. The magnetic properties of the magnetoliposomes were investigated with a superconducting quantum interference device magnetometer and nuclear magnetic resonance (NMR) spectrometry. Our results indicate that the magnetoliposomes contain approximately spherical nanoparticles averaging 20 nm in diameter. The occurrence of a phospholipid bilayer surrounding the magnetic particles is confirmed both by transmission electron micrographs of samples negatively stained with uranyl acetate and by digital fluorescence imaging microscopy measurements of magnetoliposomes labeled with fluorescein. The particles are paramagnetic at room temperature. NMR measurements show that the ratio between the relaxivities of the particles depends largely on their preparation. © 2000 American Institute of Physics.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1063/1.372656

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2

Digitale Medien

Deletion of cytosolic phospholipase A 2 promotes striated muscle growth (2003)

Kilter, Heiko ; Michael, Ashour ; Tao, Jingzang ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 9 (2003), S. 944-951

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Generation of arachidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role in the regulation of cellular homeostasis, inflammation and tumorigenesis. Here we report that cytosolic PLA2 is a negative regulator of growth, specifically of striated muscle. We ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm891

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3

Digitale Medien

Biogeology How old are bacteria from the Permian age? (2001)

Vreeland, Russell H. ; Rosenzweig, William D. ; Powers, Dennis W.

[s.l.] : Nature Publishing Group

Nature 411 (2001), S. 155-156

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Vreeland et al. reply Hazen and Roedder touch on several geological issues raised by our limited description of the Permian Salado Formation. In our study, we sampled coarse halite in dissolution pipes for testing for viable Permian-age bacteria. A synsedimentary age ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/35075665

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4

Digitale Medien

Heterodimeric structure of superoxide dismutase in complex with its metallochaperone (2001)

Lamb, Audrey L. ; Torres, Andrew S. ; O'Halloran, Thomas V. ; [weitere]

[s.l.] : Nature Publishing Group

Nature structural biology 8 (2001), S. 751-755

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ISSN: 1072-8368

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The copper chaperone for superoxide dismutase (CCS) activates the eukaryotic antioxidant enzyme copper, zinc superoxide dismutase (SOD1). The 2.9 Å resolution structure of yeast SOD1 complexed with yeast CCS (yCCS) reveals that SOD1 interacts with its metallochaperone to form a complex ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nsb0901-751

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5

Digitale Medien

Structure of β-lactam synthetase reveals how to synthesize antibiotics instead of asparagine (2001)

Miller, Matthew T. ; Bachmann, Brian O. ; Townsend, Craig A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature structural biology 8 (2001), S. 684-689

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ISSN: 1072-8368

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The enzyme β-lactam synthetase (β-LS) catalyzes the formation of the β-lactam ring in clavulanic acid, a clinically important β-lactamase inhibitor. Whereas the penicillin β-lactam ring is generated by isopenicillin N synthase (IPNS) in the presence of ferrous ion and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/90394

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6

Digitale Medien

Climate change (Communication arising) Regional warming and malaria resurgence (2002)

Hulme, Mike ; Rosenzweig, Cynthia ; Mitchell, Timothy D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 420 (2002), S. 627-628

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Disease outbreaks are known to be often influenced by local weather, but how changes in disease trends might be affected by long-term global warming is more difficult to establish. In a study of malaria in the African highlands, Hay et al. found no significant change in long-term climate at ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/420627a

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