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  • Springer  (92)
  • Institute of Physics  (40)
  • American Association for the Advancement of Science (AAAS)  (4)
  • 2020-2022  (95)
  • 2000-2004  (33)
  • 1960-1964  (8)
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  • 1
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    Evidence for a large-scale remnant of subducted lithosphere beneath Fiji (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-30
    Description: We combine spatial variations of P- and S-wave speeds, 1000 fault plane solutions, and 6600 well-determined hypocenters to investigate the nature of subducted lithosphere and deep earthquakes beneath the Tonga back-arc. We show that perplexing patterns in seismicity and fault plane solutions can be accounted for by the juxtaposition of a steep-dipping Wadati-Benioff zone and a subhorizontal remnant of slab that is no longer attached to the actively subducting lithosphere. The detached slab may be from a previous episode of subduction along the fossil Vitiaz trench about 5 to 8 million years ago. The juxtaposition of slabs retains a large amount of subducted material in the transition zone of the mantle. Such a configuration, if common in the past, would allow the preservation of a primordial component in the lower mantle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, W P -- Brudzinski, M R -- New York, N.Y. -- Science. 2001 Jun 29;292(5526):2475-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology, University of Illinois, Urbana, IL 61801, USA. w-chen@uiuc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11431564" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The chi-Chi earthquake sequence: active, out-of-sequence thrust faulting in taiwan (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-06
    Description: We combined precise focal depths and fault plane solutions of more than 40 events from the 20 September 1999 Chi-Chi earthquake sequence with a synthesis of subsurface geology to show that the dominant structure for generating earthquakes in central Taiwan is a moderately dipping (20 degrees to 30 degrees ) thrust fault away from the deformation front. A second, subparallel seismic zone lies about 15 kilometers below the main thrust. These seismic zones differ from previous models, indicating that both the basal decollement and relic normal faults are aseismic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kao -- Chen -- New York, N.Y. -- Science. 2000 Jun 30;288(5475):2346-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Earth Sciences, Academia Sinica, Nankang, Taipei, Taiwan 115, Republic of China. Department of Geology and Mid-America Earthquake (MAE) Center, University of Illinois, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10875915" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Earthquakes beneath the Himalayas and Tibet: evidence for strong lithospheric mantle (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-26
    Description: Eleven intracontinental earthquakes, with magnitudes ranging from 4.9 to 6, occurred in the mantle beneath the western Himalayan syntaxis, the western Kunlun Mountains, and southern Tibet (near Xigaze) between 1963 and 1999. High-resolution seismic waveforms show that some focal depths exceeded 100 kilometers, indicating that these earthquakes occurred in the mantle portion of the lithosphere, even though the crust has been thickened there. The occurrence of earthquakes in the mantle beneath continental regions where the subduction of oceanic lithosphere ceased tens of millions years ago indicates that the mantle lithosphere is sufficiently strong to accumulate elastic strain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Wang-Ping -- Yang, Zhaohui -- New York, N.Y. -- Science. 2004 Jun 25;304(5679):1949-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15218145" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Overriding imatinib resistance with a novel ABL kinase inhibitor (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-17
    Description: Resistance to the ABL kinase inhibitor imatinib (STI571 or Gleevec) in chronic myeloid leukemia (CML) occurs through selection for tumor cells harboring BCR-ABL kinase domain point mutations that interfere with drug binding. Crystallographic studies predict that most imatinib-resistant mutants should remain sensitive to inhibitors that bind ABL with less stringent conformational requirements. BMS-354825 is an orally bioavailable ABL kinase inhibitor with two-log increased potency relative to imatinib that retains activity against 14 of 15 imatinib-resistant BCR-ABL mutants. BMS-354825 prolongs survival of mice with BCR-ABL-driven disease and inhibits proliferation of BCR-ABL-positive bone marrow progenitor cells from patients with imatinib-sensitive and imatinib-resistant CML. These data illustrate how molecular insight into kinase inhibitor resistance can guide the design of second-generation targeted therapies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shah, Neil P -- Tran, Chris -- Lee, Francis Y -- Chen, Ping -- Norris, Derek -- Sawyers, Charles L -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):399-401.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematology and Oncology, Department of Medicine, The David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256671" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Antineoplastic Agents/metabolism/*pharmacology/therapeutic use ; Benzamides ; Binding Sites ; Cell Division/drug effects ; Cell Line ; Clinical Trials, Phase I as Topic ; Dasatinib ; Drug Resistance, Neoplasm ; Enzyme Inhibitors/metabolism/pharmacology/therapeutic use ; Fusion Proteins, bcr-abl/*antagonists & inhibitors/chemistry/genetics/metabolism ; Hematopoietic Stem Cells/drug effects ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy ; Mice ; Mice, SCID ; Mutation ; Piperazines/*pharmacology/therapeutic use ; Protein Conformation ; Pyrimidines/metabolism/*pharmacology/therapeutic use ; Thiazoles/metabolism/*pharmacology/therapeutic use ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    High production of heterologous proteins in Escherichia coli using the thermo-regulated T7 expression system (2002)
    Springer
    Details
    Publication Date: 2002-03-01
    Print ISSN: 0175-7598
    Electronic ISSN: 1432-0614
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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  • 6
    Electronic Resource
    Electronic Resource
    Tyrosine phosphate on paper chromatograms ofDrosophila melanogaster (1960)
    Springer
    Cellular and molecular life sciences 16 (1960), S. 410-411 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es wird gezeigt, dass die auf zweidimensionalen Chromatogrammen vonDrosophila melanogaster auftretenden Ninhydrin-positiven Flecken, die als P1+P2 (Peptide) bezeichnet wurden, sehr viel freies Tyrosin-O-phosphat enthalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02178836
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  • 7
    Electronic Resource
    Electronic Resource
    Changes in DNA and RNA during embryonic development of the merogonic combinationTriton palmatus (♀) ×Triton cristatus (♂) (1961)
    Springer
    Cellular and molecular life sciences 17 (1961), S. 177-178 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Der Gehalt an RNS und DNS früher Entwicklungsstadien des BastardmerogonsTriton palmatus (♀)×Triton cristatus ♂ wurde gemessen. Es zeigt sich, dass trotz der Kern-Plasmadisharmonie diese letale Kombination in der Lage ist, beide Nukleinsäuren zu synthetisieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02160368
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  • 8
    Electronic Resource
    Electronic Resource
    Experiments concerning the incorporation of labelled adenine into ribonucleic acid in normal sea urchin embryos and in the hybridParacentrotus ♀ xArbacia ♂ (1962)
    Springer
    Cellular and molecular life sciences 18 (1962), S. 522-524 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Inkubation der Seeigelkeime mit14C-Adenin ergab, dass bei reinen Arten der Einbau der markierten Substanz in die RNS von der Mesenchymblastula bis zum Pluteus eindeutig zunimmt. Parallel zur DNS-Synthese verläuft die Zunahme beiParacentrotus undSphaerechinus viel rascher als beiArbacia. Beim Bastard PA nimmt dieser Einbauprozess mit Beginn der morphogenetischen Hemmung (nach ca. 26 h) rasch ab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151611
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  • 9
    Electronic Resource
    Electronic Resource
    The oxidation of gallium nitride epilayers in dry oxygen (2000)
    Springer
    Applied physics 71 (2000), S. 191-194 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 81.60; 61.10
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. The oxidation of GaN epilayers in dry oxygen has been investigated. The GaN epilayers, about 1 μm thick, were grown on (0001) sapphire substrates by rapid thermal process/low pressure metalorganic chemical vapor deposition. Bulk θ-2θ X-ray diffraction (XRD) data showed that the slight oxidation of GaN began to occur at 800 °C for 6 h. The oxide was identified as the monoclinic β-Ga2O3. The GaN epilayers were completely oxidized at 1050 °C for 4 h or at 1100 °C for 1 h. For all samples, the strongest oxide’s peak is (11-3), and (30-6) followed. There is a rapid oxidation process in the initial stage of oxidation, and a relatively slow process followed when the temperature was over 1000 °C. The oxidation of two stages was limited by the rate of an interfacial reaction mechanism and by the diffusion mechanism, respectively. When the temperature reaches 1100 °C, the oxidation rate is very fast, which is considered as the results of the GaN decomposition at high temperature under atmosphere. The oxide layers were also observed by a scanning electron microscope, which shows a rough oxide surface and an expansion of the volume of 40%. The photoluminescence (PL) seriously influenced by the oxidation is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003390050052
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  • 10
    Electronic Resource
    Electronic Resource
    Genetic mapping of the powdery mildew resistance gene Pm6 in wheat by RFLP analysis (2000)
    Springer
    Theoretical and applied genetics 100 (2000), S. 564-568 
    Details
    ISSN: 1432-2242
    Keywords: Key words Triticum aestivum ; Tritiam timopheevii ; Pm6 ; Introgression lines ; RFLP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Pm6 in bread wheat (Triticum aestivum L.), which was transferred from Triticum. timopheevii L., is a gene conferring resistance to the powdery mildew disease caused by Erysiphe graminis f. sp. tritici. Six near-isogenic lines ( NILs ) of Pm6 in a cultivar ’Prins’ background were analyzed to map this gene using restriction fragment length polymorphism (RFLP). Each of the six NILs possessed a T. timopheevii-derived segment, varying in length, and associated with powdery mildew resistance. Lines IGV1–465 (FAO163b/ 7*Prins) and IGV1–467 (Idaed 59B/7*Prins) had the shortest introgressed segments, which were detected only by DNA probes BCD135 and PSR934, respectively. The polymorphic loci detected by both probes were mapped to the long arm of chromosome 2B. Lines IGV1–458 (CI13250/7*Prins) and IGV1–456 (CI12559/8*Prins) contained the longest T. timopheevii segments involving both arms of donor chromosome 2G across the centromere. All these introgressed segments had an overlapping region flanked by the loci xpsr934 and xbcd135 on 2BL. Thus, Pm6 was located in this region since the powdery mildew resistance in all the NILs resulted from the introgressed fragments. Using the F2 mapping population from a cross of IGV1–463 (PI170914/7*Prins)×Prins, Pm6 was shown to be closely linked to the loci xbcd135 and xbcd266 at a genetic distance of 1.6 cM and 4.8 cM, respectively. BCD135 was successfully used in detecting the presence of Pm6 in different genetic backgrounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050074
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