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  • G20 - General, L10 - General  (1)
  • Nucleic acid structure, Phsyical and Biochemical Characterisation of DNA  (1)
  • Oxford University Press  (2)
  • International Union of Crystallography (IUCr)
  • 2020-2022
  • 2015-2019  (2)
  • 1985-1989
  • 1975-1979
Sammlung
Verlag/Herausgeber
  • Oxford University Press  (2)
  • International Union of Crystallography (IUCr)
Erscheinungszeitraum
  • 2020-2022
  • 2015-2019  (2)
  • 1985-1989
  • 1975-1979
Jahr
  • 1
    Publikationsdatum: 2015-03-01
    Beschreibung: We systematically varied conditions of two-dimensional (2D) agarose gel electrophoresis to optimize separation of DNA topoisomers that differ either by the extent of knotting, the extent of catenation or the extent of supercoiling. To this aim we compared electrophoretic behavior of three different families of DNA topoisomers: (i) supercoiled DNA molecules, where supercoiling covered the range extending from covalently closed relaxed up to naturally supercoiled DNA molecules; (ii) postreplicative catenanes with catenation number increasing from 1 to ~15, where both catenated rings were nicked; (iii) knotted but nicked DNA molecules with a naturally arising spectrum of knots. For better comparison, we studied topoisomer families where each member had the same total molecular mass. For knotted and supercoiled molecules, we analyzed dimeric plasmids whereas catenanes were composed of monomeric forms of the same plasmid. We observed that catenated, knotted and supercoiled families of topoisomers showed different reactions to changes of agarose concentration and voltage during electrophoresis. These differences permitted us to optimize conditions for their separation and shed light on physical characteristics of these different types of DNA topoisomers during electrophoresis.
    Schlagwort(e): Nucleic acid structure, Phsyical and Biochemical Characterisation of DNA
    Print ISSN: 0305-1048
    Digitale ISSN: 1362-4962
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Oxford University Press
    Publikationsdatum: 2015-09-30
    Beschreibung: Using multi-year, firm-level surveys for 53 countries, this paper explores the impact of bank competition on firms’ access to finance. We find that low competition, as measured by high values on the Lerner index or Boone indicator, diminishes firms’ access to finance. In addition, the impact of competition on access to finance depends on the quality and scope of credit information sharing mechanisms, and better credit information mitigates the damaging impact of low competition. Overall, our paper offers consistent international evidence that supports the market power hypothesis, which argues that market power reduces access, and rejects the information hypothesis, which suggests that low competition improves access because it allows banks to internalize the investment in building firm-specific relationships.
    Schlagwort(e): G20 - General, L10 - General
    Print ISSN: 0258-6770
    Digitale ISSN: 1564-698X
    Thema: Wirtschaftswissenschaften
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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