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  • 1
    Publication Date: 2015-09-26
    Description: Long terminal repeat (LTR) retrotransposons are an abundant class of genomic parasites that replicate by insertion of new copies into the host genome. Fungal LTR retrotransposons prevent mutagenic insertions through diverse targeting mechanisms that avoid coding sequences, but conserved principles guiding their target site selection have not been established. Here, we show that insertion of the fission yeast LTR retrotransposon Tf1 is guided by the DNA binding protein Sap1 and that the efficiency and location of the targeting depend on the activity of Sap1 as a replication fork barrier. We propose that Sap1 and the fork arrest it causes guide insertion of Tf1 by tethering the integration complex to target sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, Jake Z -- Rosado-Lugo, Jesus D -- Cranz-Mileva, Susanne -- Ciccaglione, Keith M -- Tournier, Vincent -- Zaratiegui, Mikel -- 1R01GM105831/GM/NIGMS NIH HHS/ -- 5T32GM008339/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Sep 25;349(6255):1549-53. doi: 10.1126/science.aaa3810.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Nelson A133, 604 Allison Road, Piscataway, NJ 08854, USA. ; Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Nelson A133, 604 Allison Road, Piscataway, NJ 08854, USA. zaratiegui@dls.rutgers.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26404838" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA Replication ; DNA-Binding Proteins/genetics/*metabolism ; *Mutagenesis, Insertional ; Retroelements/*genetics ; Schizosaccharomyces/*genetics ; Schizosaccharomyces pombe Proteins/genetics/*metabolism ; Terminal Repeat Sequences/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2021-05-19
    Description: Hoy por hoy el recurso información constituye el activo más importante proveniente de las instancias con las cuales una organización está en permanente contacto, así como la que se origina del ejercicio de su función. Por ello, al transcurrir el tiempo aumenta exponencialmente, magnificando la necesidad de almacenar y gestionar eficientemente los datos para que estos adquieran un verdadero significado en los procesos de la organización y satisfagan las necesidades de sus clientes y organismos de control. En consecuencia, los objetivos estratégicos en materia de control de la calidad de la información de organizaciones como los centros de investigación nacionales se han orientado hacia la estandarización de los datos generados por sus grupos, obteniendo así el máximo aprovechamiento del resultado de años de exploración, inversión económica, recurso humano calificado y capacidades operativas instaladas. La Dirección General Marítima en este aspecto respondió a los crecientes requerimientos de precisión y calidad que demanda la investigación científica y tecnológica, a nivel nacional e internacional, con el diseño e implementación de la herramienta software denominada Central de Información Marina Colombiana; la cual reúne elementos de administración basados en las banderas de calidad del Ocean Data View para parámetros de oceanografía física, oceanografía química, oceanografía biológica, y meteorología marina y costera. Promoviendo de esta manera la disponibilidad del recurso para los usuarios que lo requieran, independiente de la ubicación geográfica y bajo condiciones de seguridad que permiten protegerlos del uso inadecuado.
    Description: Currently, the information constitutes the most important asset coming from the instances the organization is in permanent contact with, as well as the one originated from the exercise of its function. That is why as the time goes by, it increases exponentially, magnifying the necessity to store and to administrate the data efficiently so they acquire a true meaning in the processes of the organization and satisfy the necessities of the clients and control organisms. In consequence, the strategic objectives as regards of the information quality control in organizations like national investigation centers, have been guided toward the standardization of the data generated by their groups, getting the maximum use of the result of years of exploration, economic investment, qualified human resource and installed operative capacities. The Dirección General Marítima, in this aspect responds to the growing requirements of precision and quality that the scientific and technological investigation at national and international level demands through the design and implementation of the tool software denominated Central de Información Marina Colombiana; which gathers administration elements based on Ocean Data View quality flags for parameters of physical oceanography, chemical oceanography, biological oceanography, and marine and coastal meteorology. Promoting this way the readiness of the resource for the users that require it independent of the geographical location and under security conditions to protect them of the inadequate use.
    Description: Published
    Keywords: Central de Información Marina Colombiana ; Información marina ; Intercambio de datos oceanográficos ; Programación extrema ; Data warehouse ; Herramienta software ; Banderas de calidad ; ASFA_2015::D::Databases ; ASFA_2015::P::Physical oceanography ; ASFA_2015::G::Geographic information systems
    Repository Name: AquaDocs
    Type: Journal Contribution , Not Known
    Format: pp.3-16
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