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  • 1
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    The Second Life of Natural Killer (NK) Cells (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of “Innate lymphoid cells” (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications.
    Keywords: R5-920 ; RC581-607 ; natural killer cells ; ILC ; NK cells ; immune therapy ; viral infection ; NK cell education ; immunotherapy ; MHC-I ; cancer ; immune regulation ; adaptive immunity ; bic Book Industry Communication::M Medicine
    Language: English
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    E-BOOK
  • 2
    Electronic Resource
    Electronic Resource
    Calculations of the Activation Energies of Some Reactions between the Halogens and the Ethylene Double Bond (1934)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 56 (1934), S. 1096-1101 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01320a027
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Virus-like particles in acute lymphoblastic leukemia (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 100-101 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung In Knochenmark-Monocyten eines fünfjährigen Mädchens konnten im Cytoplasma Einschlüsse beobachtet werden, die mit gewundenen Membranen und virusähnlichen Partikeln fegüllt waren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01913278
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Unusual membranous body in the spermatids of pig tail monkey (1970)
    Springer
    Naturwissenschaften 57 (1970), S. 458-459 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607747
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  • 5
    Electronic Resource
    Electronic Resource
    Crystalloid inclusions in the connective tissue of spider venom gland (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 325-326 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Nous décrivons des inclusions cristallines observées dans l'élytre extracellulaire des glandes venimeuses deLoxosceles reclusa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928719
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructure of retinal vessel in retinoblastoma (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1000-1000 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Les vaisseaux de la rétine humaine dans la rétinoblastoma contiennent les cellules endothéliales, les péricytes, et les membranes de la base. Quelques villosités poussent à la surface endothéliale vers le vaisseau du lumen. Les barres terminales se trouvent près de la jonction endothéliale. Au niveau des cellules endothéliales on observe un grand nombre des replis membraneux.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114156
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  • 7
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    Mechanism of multidecadal oscillation in north Atlantic ocean and implications for Asian climate (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-04-17
    Description: The North Atlantic sea surface temperature multidecadal oscillation, or AMO, has a substantial impact on both the global and local climate. The authors suggest a delayed oscillator model of interdecadal sea-air coupling to describe the underlying physical principles of AMO. On the basis of the impact of cumulative atmospheric forcing on ocean circulation, they also develop new AMOC indicators and shed light on the AMO's dynamics. To explain the remote impacts of AMO, the authors propose and identify the Atlantic-West Pacific trans-basin SST mode as a significant mode of global inter-oceanic interdecadal variability based on observational and model evidence. They discover that this mode started to change from a negative to a positive phase in the 1990s, which led to significant changes in the regional SST system in the Indian Ocean and the Arabian Sea. As a result, the warming rate of the Arabian Sea began to significantly accelerate in the 1990s. The Atlantic-West Pacific trans-basin SST mode corresponds to the synchronous changes of the Atlantic warm pool and the West Pacific warm pool, which have an important impact on the zonal Walker circulation; on the other hand, the Atlantic-West Pacific trans-basin SST mode can modulate the SST gradient in the northern and southern hemispheres, causing the variability of the meridional Hadley circulation and the north-south shift of the ITCZ position. These AMO-related changes have an impact on the climate in Asia as well as extreme weather (such tropical cyclones and heatwaves).
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 8
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    On the influences of the continental shelf bathymetry correction in Prydz Bay, East Antarctica (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-06-05
    Description: The bathymetry around Antarctica can govern the shelf sea circulations and play a key role in conditioning water masses. In Prydz Bay, the Prydz Bay Gyre and coastal currents are also determined by the continental shelf topography. However, due to the paucity of beam echo sounding data, the bathymetric datasets in Prydz Bay still have large uncertainties. With the aid of in situ hydrographic observations, this study focuses on the correction of an up-to-date bathymetric dataset and the resultant influences on the shelf circulation and the basal melting of the ice shelves. The corrected bathymetry mainly improves the biased shallow representations in the uncorrected bathymetric data set, with a maximum change of ~500 m deepening in the eastern flank of Prydz Bay. Sensitivity numerical experiments show that the bathymetric corrections in Prydz Bay have a significant impact on the circulation pattern and onshore warm water intrusions. In addition, the corrected bathymetry markedly decreases the heat transport towards the calving front of the Amery Ice Shelf. The onshore heat transport reduces by ~22.18% from ~5.23×10〈sup〉13〈/sup〉 J s〈sup〉-1〈/sup〉 to ~4.07×10〈sup〉13〈/sup〉 J s〈sup〉-1〈/sup〉 over the outer shelf. Over the inner shelf, the heat transport towards the Amery Ice Shelf reduces by ~18.15% from ~5.95×10〈sup〉13〈/sup〉 J s〈sup〉-1 〈/sup〉to ~4.87×10〈sup〉13〈/sup〉 J s〈sup〉-1〈/sup〉. Consequently, the temporally and spatially averaged basal melting rate of the Amery Ice Shelf reduces by ~13.04% from ~0.69 m yr〈sup〉-1〈/sup〉 to ~0.60 m yr〈sup〉-1〈/sup〉.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 9
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    Multidecadal variability and decadal prediction of wintertime surface air temperature over the East Asian winter monsoon domain (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-05-22
    Description: This study investigates the influence of the winter NAO on the multidecadal variability of winter East Asian surface air temperature (EASAT) and its decadal prediction. The observational analysis shows that the winter EASAT and East Asian minimum SAT (EAmSAT) display strong in-phase fluctuations and a significant 60–80-year multidecadal variability, apart from a long-term warming trend. The winter EASAT experienced a decreasing trend in the last two decades, which is conducive to the occurrence of winter extremely cold events in East Asia in recent years. The winter NAO leads the detrended winter EASAT by 12–18 years with a maximumly significant positive correlation at the leading time of 15 years. Further analysis shows that ENSO may affect winter EASAT interannual variability, but does not affect the robust leading relationship between the winter NAO and EASAT. We present the coupled oceanic-atmospheric bridge (COAB) mechanism of the NAO influences on winter EASAT multidecadal variability through its accumulated delayed effect of ~15 years on the Atlantic Multidecadal Oscillation (AMO) and Africa–Asia multidecadal teleconnection (AAMT) pattern. Based on the COAB mechanism an NAO-based linear model for predicting winter decadal EASAT is constructed, with good hindcast performance. The winter EASAT for 2020–2034 is predicted to keep on fluctuating downward until ~2025, implying a high probability of occurrence of extremely cold events in coming winters in East Asia, and then turn towards sharp warming. The predicted 2020/21 winter EASAT is almost the same as the 2019/20 winter.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 10
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    A palaeoecological study investigating the impacts of multiple tephra depositions on a lacustrine ecosystem in Northeast China, using diatoms as environmental indicators (2023)
    In:  Journal of Paleolimnology
    Details
    Publication Date: 2023-04-27
    Description: Tephra layers are common in lake sediments and although they have often been used as chronological controls, few studies have investigated the impacts of past tephra depositions on lake ecosystems (Tephropalaeoecology). For the first time we systematically assess how different types of tephra layers vary in their ecological impact on the same lacustrine system. We use a diatom-based tephropalaeoecological approach to infer the impacts of five tephra deposits on Lake Sihailongwan, a well-studied volcanic lake in Northeast China, over the past 30,000 years. The five tephra layers (including two micro-tephras) have varying thicknesses and were deposited in time periods with different climatic conditions. Changes in diatom communities and chrysophyte-cyst concentrations between pre- and post-tephra samples were used to infer changes in lake conditions and highlight the importance of lake background conditions in mediating the impact of tephra. While the two micro-tephra layers did not cause observable changes, the three thicker tephras induced pronounced changes in lake conditions and thus diatom communities. The two thick tephras deposited in more eutrophic and warmer lake conditions caused larger responses from diatoms. We argue that water-column phosphorus decreased due to reduced sediment–water-phosphorus loading as thick tephra layers formed an impermeable layer at the lake bottom. This is supported by a decrease in total diatom concentration and a decline in high phosphorus-requiring taxa such as Discostella stelligeroides and Stephanodiscus minutulus as well as modern limnological observations which showed that groundwater influxes from the lake bottom are the main source of nutrients to the lake. By contrast, the thick tephra deposited in more oligotrophic and colder lake conditions caused less conspicuous changes. When the lake was already low in phosphorus, diatoms did not respond to a further decline in phosphorus but rather responded to the minor increase in silica from the dissolution of tephra particles in the water column. This was inferred from the slight increases in overall diatom concentration and opportunistic taxa such as Pantocsekiella comensis f. minima. Diatom analysis of the post-tephra sediments above the three thick tephras showed that the aquatic ecosystem did not completely recover, indicating the long-lasting effects of these thick tephras and shifts to new lake-ecosystem equilibria.
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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