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  • Aquacultural homeopathy  (1)
  • Echovirus  (1)
  • 2020-2023  (1)
  • 2020-2022  (1)
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  • 2020-2023  (1)
  • 2020-2022  (1)
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  • 1
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    Antiviral activity of Sargassum fluitans seaweed against echovirus 9, coxsackievirus A16 and coxsackievirus A24 (2021)
    Details
    Publication Date: 2021-11-23
    Description: Enteroviruses cause human diseases such as Mouth, Hand and Foot Syndrome, hemor rhagic conjunctivitis, aseptic meningitis, and viral meningoencephalitis. As yet, there is not specific therapy for most enteroviruses infections. The brown seaweeds of Sargassum genus synthesize a great variety of metabolites, which make them potential sources of compounds with antiviral activities. This study aimed to evaluate the in vitro antiviral activity of a hydro-alcoholic extract of Sargassum fluitans against three human enteroviruses: coxsackievirus A16, echovirus 9 and coxsackievirus A24. Cytotoxicity of the extract was evaluated in Vero, RD and Hep-2 cells by MTT method. Antiviral activity (EC50) was assessed by cytopathic effect inhibition in cells. Extracellular virucidal activity and reduction of viral yield were determined by endpoint viral titration assay. The antiviral activity was characterized by a time of addition assay. The extract showed antiviral inhibi- tory activity against all tested viruses. The extract also exhibited a virucidal effect against E9 and CVA16 and reduced the formation of infective particles in the cells in more than three logs. The extract was able to inhibit earlier and late stages in the enterovirus replication cycle. In conclusion, the present study demonstrated the effective in vitro antiviral activity of the brown seaweed Sargassum fluitans against clinically relevant enteroviruses, supporting their use as potential source of antiviral compounds.
    Description: Los enterovirus causan enfermedades humanas tales como el Síndrome de Mano, Pie y Boca, la conjuntivitis hemorrágica y la meningoencefalitis viral. Hasta el momento no existe una terapia específica para la mayoría de las infecciones por enterovirus. Las algas pardas del género Sargassum sintetizan una gran variedad de metabolitos, los cuales les convierten en fuentes potenciales de compuestos con actividad antiviral. Este estudio tuvo como objetivo evaluar la actividad antiviral in vitro de un extracto hidroalcohólico de Sargassum fluitans contra tres enterovirus humanos: coxsackievirus A16, echovirus 9 and coxsackievirus A24.La citotoxicidad del extracto se evaluó en las células Vero, RD y Hep-2 mediante el método del MTT. La actividad antiviral (CE50) se evaluó mediante la inhibición del efecto citopático en las células. La actividad virucida extracelular y la reducción del número de viriones se determinaron mediante ensayo de titulación viral de punto final. La actividad antiviral se carac- terizó mediante un ensayo de tiempo de adición. El extracto mostró actividad antiviral inhibitoria contra todos los virus probados. El extracto también exhibió efecto virucida contra el echovirus 9 y el coxsackievirus A16 y redujo la formación de partículas virales infectivas en las células en más de tres logaritmos. El extracto fue capaz de inhibir las etapas tempranas y tardías del ciclo replicativo. Se concluye que el pre- sente estudio demostró la efectiva actividad antiviral in vitro del alga parda Sargassum fluitans contra enterovirus clínicamente relevantes, apoyando su uso como fuente potencial de compuestos antivirales.
    Description: Published
    Description: Refereed
    Keywords: Sargassum fluitans ; Antiviral ; Enterovirus ; Echovirus ; Coxsackievirus
    Repository Name: AquaDocs
    Type: Journal Contribution
    Format: pp.43-55
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  • 2
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    Efecto de medicamentos homeopáticos de uso humano en la maduración sexual de reproductores de ostión americano Crassostrea virginica. (2022)
    Details
    Publication Date: 2022-11-20
    Description: En el Centro Ostrícola Tecnológico de Tabasco, COTET-México, se evaluó el efecto de medicamentos homeopáticos autorizados para uso humano por la Secretaría de Salud de México y productos homeopáticos diseñados por el CIBNOR, durante el acondicionamiento gonádico de reproductores de ostión americano Crassostrea virginica. En el diseño experimental se consideró una muestra inicial (T0), dos tratamientos homeopáticos [T1 (ViP-7C + ViA-7C), T2 (PhA-7C + SiT-7C)] y un tratamiento control T3 (agua destilada). La respuesta fisiológica se cuantificó mediante la frecuencia (%) de estadios de desarrollo gonádico en hembras y machos, durante un periodo de 30 días. Al concluir el bioensayo, los reproductores que recibieron los tratamientos T1 y T2 fueron capaces de re-madurar, desovar y producir larvas viables. Esto sugiere una potencial aplicabilidad de estos tratamientos en la producción comercial de semillas de C. virginica.
    Description: At the Centro Ostrícola Tecnológico de Tabasco (COTET-MX), the effect of homeopathic medicines authorized for human use by the Ministry of Health of Mexico and homeopathic products designed by CIBNOR, were evaluated during gonadal conditioning of american oyster Crassostrea virginica broodstock. In the experimental design, an initial sample (T0), two homeopathic treatments [T1 (ViP-7C + ViA-7C), T2 (PhA-7C + SiT-7C)] and a control treatment T3 (distilled water) were considered. The physiological response was quantified by the frequency (%) of gonadal development stages in females and males, during a period of 30 days. At the end of the bioassay, the broodstock that received treatments T1 and T2 were able to re-mature, spawn and produce viable larvae. This suggests a potential applicability of these treatments in the commercial production of C. virginica seeds.
    Description: Published
    Description: Refereed
    Keywords: Homeopatía acuícola ; Moluscos ostreidos ; Acondicionamiento gonádico ; Re-maduración sexual ; Aquacultural homeopathy ; Ostreid molluscs ; Gonadal conditioning ; Sexual re-maturation
    Repository Name: AquaDocs
    Type: Journal Contribution
    Format: pp.66-74
    Location Call Number Expected Availability
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    PAPER (OA)
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