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  • DNA-binding proteins  (1)
  • Spacecraft Propulsion and Power  (1)
  • design metrics analyzer  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of software engineering 1 (1995), S. 43-55 
    ISSN: 1573-7489
    Keywords: Design metrics ; design metrics analyzer ; metrics model ; software metrics ; software quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Metric monsters are stumbling blocks that prevent software metrics-guided methodologies from attaining product and process improvement. Metric monsters can occur during the identification, collection or application of software metrics. In our research, we have developed and tested our design metrics over a five-year period and have found them to be excellent predictors of error-prone modules. Based on this research, we will identify some of the monsters that occur in the quantitative analyses of software and its development processes, and present our approach in formulating a design metrics model that avoids these monsters. This model consists of software tools, guidelines and actions for the application of software design metrics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5028
    Keywords: cucumber ; cytokinin-responsive ; DNA-binding proteins ; hydroxypyruvate reductase ; transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Transcription of the cucumber hpr-A gene is responsive to cytokinin and light. To investigate the molecular basis for transcriptional regulation by cytokinin, we have identified DNA sequences and proteins that may be involved in the regulation of hpr-A gene expression. Transient expression assays in etiolated cucumber cotyledons indicate that the 315 bp fragment (−382 to −67) contains sequences necessary for cytokinin responsiveness of the luciferase reporter gene. Band shift assays detected cytokinin-enhanced and -reduced protein binding sites in a 97 bp fragment (−382 to −285) upstream of the hpr-A gene. DNase I footprinting identified two protein-protected sites, a 15 bp sequence, 5′-AAATGACGAAAATGC-3′, that contains an as-1 TGACG motif found in other plant promoters, and a 13 bp sequence, 5′-AAGATTGATTGAG-3′, of unknown function. Two-dimensional band shift analysis of the cytokinin-responsive DNA protein complex revealed the presence of six DNA protein interactions. Band shift assays showed that cytokinin and light have different effects on the interaction of nuclear proteins to the 97 bp fragment of the hpr-A gene. These data suggest that cytokinin and light do not share identical signal transduction pathways in regulating hpr-A gene expression.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2019-07-13
    Description: For many decades, the U.S. rocket propulsion industrial base has performed remarkably in developing complex liquid rocket engines that can propel critical payloads into service for the nation, as well as transport people and hardware for missions that open the frontiers of space exploration for humanity. This has been possible only at considerable expense given the lack of detailed guidance that captures the essence of successful practices and knowledge accumulated over five decades of liquid rocket engine development. In an effort to provide benchmarks and guidance for the next generation of rocket engineers, the Joint Army Navy NASA Air Force (JANNAF) Interagency Propulsion Committee published a liquid rocket engine (LRE) test and evaluation (T&E) guideline document in 2012 focusing on the development challenges and test verification considerations for liquid rocket engine systems. This document has been well received and applied by many current LRE developers as a benchmark and guidance tool, both for government-driven applications as well as for fully commercial ventures. The USAF Space and Missile Systems Center (SMC) has taken an additional near-term step and is directing activity to adapt and augment the content from the JANNAF LRE T&E guideline into a standard for potential application to future USAF requests for proposals for LRE development initiatives and launch vehicles for national security missions. A draft of this standard was already sent out for review and comment, and is intended to be formally approved and released towards the end of 2017. The acceptance and use of the LRE T&E guideline is possible through broad government and industry participation in the JANNAF liquid propulsion committee and associated panels. The sponsoring JANNAF community is expanding upon this initial baseline version and delving into further critical development aspects of liquid rocket propulsion testing at the integrated stage level as well as engine component level, in order to advance the state of the practice. The full participation of the entire U.S. rocket propulsion industrial base is invited and expected at this opportune moment in the continuing advancement of spaceflight technology.
    Keywords: Spacecraft Propulsion and Power
    Type: M17-6082 , 2017 AIAA/SAE/ASEE Joint Propulsion Conference; Jul 10, 2017 - Jul 12, 2017; Atlanta, GA; United States
    Format: application/pdf
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