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  • American Chemical Society  (80)
  • Springer Nature  (17)
  • Springer Science + Business Media
  • 2020-2024  (97)
  • 2021  (97)
  • 1
    Publication Date: 2021-02-10
    Description: This is a chapter from The Criminal Act: The Role and Influence of Routine Activity Theory edited by Martin A. Andresen and Graham Farrell. This chapter is available open access under a CC BY license. Target suitability is a cornerstone of Marcus Felson's routine activities approach, and critical in determining crime rates. Recent research identifies reduced target suitability, via improved security, as central to the 'crime drop' experienced in many countries. Studies in different countries show car theft fell with far more and better vehicle security. Yet increases in household security were more modest and do not track burglary's decrease as well. In this chapter, the authors explain that apparent anomaly as due more to an improvement in the quality of household security leading to reduced burglary. It is further suggested that improvements to home insulation in the UK that brought double glazing may have, somewhat inadvertently, introduced better frames and locks for doors and windows, that in turn reduced household burglary.; This is a chapter from The Criminal Act: The Role and Influence of Routine Activity Theory edited by Martin A. Andresen and Graham Farrell. This chapter is available open access under a CC BY license. Target suitability is a cornerstone of Marcus Felson's routine activities approach, and critical in determining crime rates. Recent research identifies reduced target suitability, via improved security, as central to the 'crime drop' experienced in many countries. Studies in different countries show car theft fell with far more and better vehicle security. Yet increases in household security were more modest and do not track burglary's decrease as well. In this chapter, the authors explain that apparent anomaly as due more to an improvement in the quality of household security leading to reduced burglary. It is further suggested that improvements to home insulation in the UK that brought double glazing may have, somewhat inadvertently, introduced better frames and locks for doors and windows, that in turn reduced household burglary.
    Keywords: Criminology ; Public safety ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKV Crime & criminology
    Language: English
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  • 2
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    Springer Nature | Springer
    Publication Date: 2024-04-14
    Description: This 'Open Access' SpringerBrief provides foundational knowledge for designing autonomous, asynchronous systems and explains aspects of users relevant to designing for these systems, introduces principles for user-centered design, and prepares readers for more advanced and specific readings. It provides context and the implications for design choices made during the design and development of the complex systems that are part of operation centers. As such, each chapter includes principles to summarize the design implication that engineers can use to inform their own design of interfaces for operation centers and similar systems. It includes example materials for the design of a fictitious system, which are referenced in the book and can be duplicated and extended for real systems. The design materials include a system overview, the system architecture, an example scenario, a stakeholder analysis, a task analysis, a description of the system and interface technology, and contextualized design guidelines. The guidelines can be specified because the user, the task, and the technology are well specified as an example. Building Better Interfaces for Remote Autonomous Systems is for working system engineers who are designing interfaces used in high throughput, high stake, operation centers (op centers) or control rooms, such as network operation centers (NOCs). Intended users will have a technical undergraduate degree (e.g., computer science) with little or no training in design, human sciences, or with human-centered iterative design methods and practices. Background research for the book was supplemented by interaction with the intended audience through a related project with L3Harris Technologies (formerly Harris Corporation).
    Keywords: User Interfaces and Human Computer Interaction ; Software Engineering ; Autonomous Systems ; User-Centered Design ; Operation Centres ; Interface Technology ; Human-Centered Design ; Open Access ; User interface design & usability ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYZ Human–computer interaction::UYZG User interface design and usability ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering
    Language: English
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  • 3
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    Springer Nature | Springer
    Publication Date: 2021-02-10
    Description: This open access book explores machine learning and its impact on how we make sense of the world. It does so by bringing together two ‘revolutions’ in a surprising analogy: the revolution of machine learning, which has placed computing on the path to artificial intelligence, and the revolution in thinking about the law that was spurred by Oliver Wendell Holmes Jr in the last two decades of the 19th century. Holmes reconceived law as prophecy based on experience, prefiguring the buzzwords of the machine learning age—prediction based on datasets. On the path to AI introduces readers to the key concepts of machine learning, discusses the potential applications and limitations of predictions generated by machines using data, and informs current debates amongst scholars, lawyers and policy makers on how it should be used and regulated wisely. Technologists will also find useful lessons learned from the last 120 years of legal grappling with accountability, explainability, and biased data.
    Keywords: Science and Technology Studies ; Human Geography ; IT Law, Media Law, Intellectual Property ; Artificial Intelligence ; AI ; Machine learning ; artificial intelligence ; 'big data' ; probability theory ; history of ideas ; legal interpretation ; Transhumanism ; Futurism ; Oliver Wendell Holmes Jr ; Wendell Holmes Jr. ; legal philosophy ; machine bias ; algorithmic bias ; Open Access ; Sociology ; Human geography ; Entertainment & media law ; Artificial intelligence ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNJ Entertainment & media law ; bic Book Industry Communication::U Computing & information technology::UY Computer science::UYQ Artificial intelligence
    Language: English
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  • 4
    Publication Date: 2023-12-20
    Description: This open access book was prepared as a Final Publication of the COST Action IC1304 “Autonomous Control for a Reliable Internet of Services (ACROSS)”. The book contains 14 chapters and constitutes a show-case of the main outcome of the Action in line with its scientific goals. It will serve as a valuable reference for undergraduate and post-graduate students, educators, faculty members, researchers, engineers, and research strategists working in this field. The explosive growth of the Internet has fundamentally changed the global society. The emergence of concepts like SOA, SaaS, PaaS, IaaS, NaaS, and Cloud Computing in general has catalyzed the migration from the information-oriented Internet into an Internet of Services (IoS). This has opened up virtually unbounded possibilities for the creation of new and innovative services that facilitate business processes and improve the quality of life. However, this also calls for new approaches to ensuring the quality and reliability of these services. The objective of this book is, by applying a systematic approach, to assess the state-of-the-art and consolidate the main research results achieved in this area.
    Keywords: QA75.5-76.95 ; Human-Computer Interactopm (HCI) ; Internet of Services (IoS) ; Internet of Things (IoT) ; data communication systems ; quality of service (QoS) ; computer networks ; multimedia systems ; user interfaces ; quality of experience (QoE) ; telecommunication networks ; computer systems ; information theory ; cloud computing ; communication channels ; internet ; telecommunication traffic ; bic Book Industry Communication::U Computing & information technology::UY Computer science
    Language: English
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  • 5
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    Springer Nature
    Publication Date: 2024-03-30
    Description: environmental management; environmental law; ecojustice; ecology
    Keywords: environmental management ; environmental law ; ecojustice ; ecology ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics
    Language: English
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  • 6
    Publication Date: 2021-10-29
    Description: Prevention of viral escape and increased coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal antibodies (mAbs) targeting multiple sites of vulnerability on the coronavirus spike glycoprotein. Here we identify several potent neutralizing antibodies directed against either the N-terminal domain (NTD) or the receptor-binding domain (RBD) of the spike protein. Administered in combinations, these mAbs provided low-dose protection against SARS-CoV-2 infection in the K18-human angiotensin-converting enzyme 2 mouse model, using both neutralization and Fc effector antibody functions. The RBD mAb WRAIR-2125, which targets residue F486 through a unique heavy-chain and light-chain pairing, demonstrated potent neutralizing activity against all major SARS-CoV-2 variants of concern. In combination with NTD and other RBD mAbs, WRAIR-2125 also prevented viral escape. These data demonstrate that NTD/RBD mAb combinations confer potent protection, likely leveraging complementary mechanisms of viral inactivation and clearance.
    Print ISSN: 1529-2908
    Electronic ISSN: 1529-2916
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 7
    Publication Date: 2021-07-19
    Description: Very-long-baseline interferometry (VLBI) observations of active galactic nuclei at millimetre wavelengths have the power to reveal the launching and initial collimation region of extragalactic radio jets, down to 10–100 gravitational radii (rg ≡ GM/c2) scales in nearby sources1. Centaurus A is the closest radio-loud source to Earth2. It bridges the gap in mass and accretion rate between the supermassive black holes (SMBHs) in Messier 87 and our Galactic Centre. A large southern declination of −43° has, however, prevented VLBI imaging of Centaurus A below a wavelength of 1 cm thus far. Here we show the millimetre VLBI image of the source, which we obtained with the Event Horizon Telescope at 228 GHz. Compared with previous observations3, we image the jet of Centaurus A at a tenfold higher frequency and sixteen times sharper resolution and thereby probe sub-lightday structures. We reveal a highly collimated, asymmetrically edge-brightened jet as well as the fainter counterjet. We find that the source structure of Centaurus A resembles the jet in Messier 87 on ~500 rg scales remarkably well. Furthermore, we identify the location of Centaurus A’s SMBH with respect to its resolved jet core at a wavelength of 1.3 mm and conclude that the source’s event horizon shadow4 should be visible at terahertz frequencies. This location further supports the universal scale invariance of black holes over a wide range of masses5,6.
    Electronic ISSN: 2397-3366
    Topics: Physics
    Published by Springer Nature
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  • 8
    Publication Date: 2021-10-13
    Print ISSN: 0888-5885
    Electronic ISSN: 1520-5045
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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  • 9
    Publication Date: 2021-10-13
    Print ISSN: 0888-5885
    Electronic ISSN: 1520-5045
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
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  • 10
    Publication Date: 2021-10-29
    Description: The release of Hsp70 chaperone from tumor cells is found to trigger the full-scale anti-cancer immune response. Such release and the proper immune reaction can be induced by the delivery of recombinant Hsp70 to a tumor and we sought to explore how the endogenous Hsp70 can be transported to extracellular space leading to the burst of anti-cancer activity. Hsp70 transport mechanisms were studied by analyzing its intracellular tracks with Rab proteins as well as by using specific inhibitors of membrane domains. To study Hsp70 forms released from cells we employed the assay consisting of two affinity chromatography methods. Hsp70 content in culture medium and extracellular vesicles (EVs) was measured with the aid of ELISA. The properties and composition of EVs were assessed using nanoparticle tracking analysis and immunoblotting. The activity of immune cells was studied using an assay of cytotoxic lymphocytes, and for in vivo studies we employed methods of affinity separation of lymphocyte fractions. Analyzing B16 melanoma cells treated with recombinant Hsp70 we found that the chaperone triggered extracellular transport of its endogenous analog in soluble and enclosed in EVs forms; both species efficiently penetrated adjacent cells and this secondary transport was corroborated with the strong increase of Natural Killer (NK) cell toxicity towards melanoma. When B16 and CT-26 colon cancer cells before their injection in animals were treated with Hsp70-enriched EVs, a powerful anti-cancer effect was observed as shown by a two-fold reduction in tumor growth rate and elevation of life span. We found that the immunomodulatory effect was due to the enhancement of the CD8-positive response and anti-tumor cytokine accumulation; supporting this there was no delay in CT-26 tumor growth when Hsp70-enriched EVs were grafted in nude mice. Importantly, pre-treatment of B16 cells with Hsp70-bearing EVs resulted in a decline of arginase-1-positive macrophages, showing no generation of tumor-associated macrophages. In conclusion, Hsp70-containing EVs generated by specifically treated cancer cells give a full-scale and effective pattern of anti-tumor immune responses.
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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