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  • Books  (15)
  • bic Book Industry Communication::M Medicine  (8)
  • bic Book Industry Communication::L Law  (7)
  • 2020-2024  (15)
  • 2010-2014
  • 2021  (15)
  • 1
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    Presses de l’Université Toulouse 1 Capitole
    Publication Date: 2023-12-20
    Description: Parce que le contrat, polymorphe, irrigue de nombreux pans du droit, parce que le contrat, international, transcende les limites géographiques, l’idée d’un colloque jouant sur « Le contrat dans tous ses États » s’est imposée à ses deux organisatrices. Le caractère transfrontalier du contrat et la multiplication des échanges interétatiques rendent essentielle la problématique du conflit de lois et du conflit de juridictions, donc la thématique du droit international privé. Cette dernière a été abordée dans toute sa diversité, du droit des obligations stricto sensu, en passant par les questions familiales, sans oublier le droit du travail et les mécanismes perturbateurs au premier rang desquels les lois de police. L’internationalité ne pouvait laisser de côté la nécessaire approche comparatiste des contrats. Plusieurs réflexions de droit comparé français et anglais sont menées, car le droit continental et la Common law s’opposent traditionnellement et parce que l’actualité juridique des deux côtés de la Manche (la réforme du droit français du contrat ainsi que les négociations post-Brexit notamment) invite le juriste à s’interroger sur les influences de chacun : aussi est-il question de l’influence britannique sur les remèdes français à l’inexécution du contrat, ainsi que celle qui pourrait enrichir la clause de force majeure dans le droit français. Les interactions anglaises et françaises de la bonne foi dans les contrats au regard du pouvoir discrétionnaire du juge sont également envisagées. Ces réflexions sont prolongées par une analyse de la bonne foi dans le droit français du contrat, et, enfin, par une approche comparée du contrat dans le droit de la famille.
    Keywords: K1-7720 ; accord familial ; loi de police ; force majeure ; libre circulation ; réforme ; droit commun ; bic Book Industry Communication::L Law
    Language: French
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  • 2
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: "Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”
    Keywords: R5-920 ; RC346-429 ; nocturnal ; circadian ; tanycytes ; hippocampus ; mood ; diurnal ; seasonal ; cryptochrome ; oscillation ; small-molecule ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    Nomos Verlagsgesellschaft mbH & Co. KG
    Publication Date: 2023-12-20
    Description: Can the rules of the European Union’s E-Commerce Directive, which date back to the year 2000, continue to be valid with regard to the dissemination of content in view of the constantly evolving online environment and the changing role of platforms as a result of new business models? The relevant legal foundations in this respect at EU and national level are complex, and their interplay is often unclear. The resulting uncertainty about who is responsible and therefore liable for certain content requires a critical review of the current legal framework. This study, conducted by the Institute of European Media Law (EMR) on behalf of the State Media Authority NRW, analyses the current legal framework and reveals ways of enforcing the applicable provisions concerning illegal content. It pays special attention to the need for reform of the E-Commerce Directive in light of the changing role of platforms. Können die Regelungen der bereits im Jahr 2000 verabschiedeten europäischen E-Commerce-Richtlinie angesichts der sich stetig weiterentwickelnden Online-Welt und der auf neuen Geschäftsmodellen beruhenden veränderten Rolle von Plattformen bei der Inhalteverbreitung fortbestehen? Die einschlägigen Rechtsgrundlagen auf EU- und nationaler Ebene sind vielschichtig und das Zusammenspiel oftmals unklar. Die daraus resultierende Unsicherheit darüber, wer für einen Inhalt verantwortlich und daher haftbar ist, erfordert die Überprüfung des geltenden Rechtsrahmens. Die vom Institut für Europäisches Medienrecht (EMR) im Auftrag der Landesanstalt für Medien NRW erstellte Studie analysiert den aktuellen Rechtsrahmen und zeigt rechtliche Gestaltungsmöglichkeiten der Rechtsdurchsetzung bei als rechtswidrig einzustufenden Inhalten auf. Besonderes Augenmerk wird dabei auf den Reformbedarf der E-Commerce-Richtlinie vor dem Hintergrund der sich wandelnden Rolle von Plattformen gelegt.
    Keywords: K1-7720 ; E-Commerce Directive ; content dissemination ; online content ; bic Book Industry Communication::L Law
    Language: English
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  • 4
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: The field of arthroscopy, originating from Denmark in 1912, has rapidly evolved to diagnose and treat a wide range of musculoskeletal pathologies. Although around for sometime, arthroscopy in the field of orthopedics has traditionally focused on the knee, shoulder, or elbow, as arthroscopy of the hip is technically challenging; the deep structures of the hip, including neurovascular bundles, require specialized training and equipment to access. However, with advances in surgical techniques, hip arthroscopy has become increasingly popular given its ability to treat pathologies with previously poor prognoses such as labral tears, hip arthritis and femoroacetabular impingement (FAI). When indicated, hip arthroscopy results in shorter recovery times, low complication rates, and excellent outcomes in quality of life and pain regardless of age, gender or activity level. The purpose of this e-book is to shed light on this expanding field by delving into the common hip pathology femoroacetabular impingement, its clinical relevance, and to explore various surgical techniques and postoperative rehabilitation. It is our hope that this textbook provides valuable knowledge to advance the field of hip arthroscopy, enhance surgical techniques, and ultimately increase the quality of patient care.
    Keywords: R5-920 ; RD1-811 ; labral ; preservation ; capsular ; management ; femoroacetabular impingement ; hip arthroscopy ; FAI ; bic Book Industry Communication::M Medicine
    Language: English
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  • 5
    Publication Date: 2023-12-20
    Description: Law | Environment | Africa compiles the proceedings of the 5th Symposium and the 4th Scientific Conference of the Association of Environmental Law Lecturers from African Universities (ASSELLAU) in cooperation with the Climate Policy and Energy Security Programme for Sub-Saharan Africa run by the Konrad-Adenauer-Stiftung (KAS) and the United Nations Environment Programme (UNEP). The book
    Keywords: K1-7720 ; sustainable development ; Environment Law ; Africa ; Umweltrecht ; Afrika ; bic Book Industry Communication::L Law
    Language: English
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  • 6
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    De Gruyter
    Publication Date: 2023-12-20
    Description: Why is it that human rights are considered inviolable norms of justice at local and global scales although the number of their violations has steadily increased in modern history? On the surface, this paradox seems to be reducible to a straightforward discrepancy between idealism and reality in humanitarian affairs, but Imagining Human Rights complicates the picture by offering interdisciplinary perspectives on the imaginary status of human rights. By that the contributors mean not merely subject to imagination, open to interpretation or far too abstract, but also formative of a social imaginary with emphatic identifications and shared values. From a variety of disciplinary perspectives, they explore critical ways of engaging in rigorous interdisciplinary conversations about the origin and language of human rights, personal dignity, redistributive justice, and international solidarity. Together, they show how and why a careful examination of the intersection between disciplinary investigations is essential for imagining human rights at large. Examples range from the legitimacy of land ownership rights and the inadequacy of human faculty to make sense of mass violence in visual representation to the stewardship of human rights promoters and the genealogy of human rights.
    Keywords: K1-7720 ; PN1-6790 ; B1-5802 ; Justice ; Dignity ; Literature ; Law ; bic Book Industry Communication::L Law
    Language: English
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  • 7
    Publication Date: 2023-12-21
    Description: Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.
    Keywords: R5-920 ; RC254-282 ; Pancreatic cancer ; Therapy ; miRNAs ; Cell death ; Tumor Microenvironment ; Anti-tumor immunity ; Hypoxia ; Autophagy ; Cell Division ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
    Publication Date: 2023-12-21
    Description: The first real major breakthrough that laid the basis of HLA antibody detection in the field of solid organ transplantation, came with the introduction of the complement dependent cytotoxicity (CDC) test in 1964 by Terasaki and McClelland. Since then, methods for antibody detection have evolved remarkably from conventional cell-based assays to the current advanced solid phase systems on the Luminex platform, with increasing degree of sensitivity and specificity. The latter have been indispensable for more accurate identification of donor specific HLA antibodies in broadly reactive allo antisera, and to guide donor selection and kidney paired exchange programs through virtual crossmatching, in addition to serving as excellent tools for initiating pre-transplant desensitization and post- transplant antibody monitoring. Consensus is evolving on the optimal routine employment of these methods in donor selection strategies along with an understanding of the clinical relevance of antibodies detected by each of them. The immunoassays based on the Luminex platform and flow cytometric beads are however unable to discriminate complement fixing from non-complement fixing HLA antibodies. This is important because the former are considered clinically more pertinent in the peri-transplant period. The C1q assay which is a modification of the solid phase assay based on Luminex single antigen beads, which can be used effectively to monitor high dose IVIG desensitization is essentially a surrogate complement fixing assay, retaining the exquisite sensitivity and specificity of the Luminex platform. Currently, information obtained from these assays is preliminary and much needs to be done to standardize technologies and set a consensus ‘MFI cut off’ for antibody positivity. Besides the overriding influence of anti-HLA antibodies on overall solid organ graft survival, immune response to non-HLA antigens has become a topic of substantial interest in recent years. An ever expanding list of non-HLA antigens has been implicated in graft rejection for various organs, of which the most noted are the Major Histocompatibility Complex class I chain-related molecule A (MICA), Vimentin, Myosin, Angiotensin II type 1 receptor (AT1R), Tubulin and Collagen. MICA is one of the most polymorphic and extensively studied non-HLA antigenic targets especially in renal transplantation. Although there are clear indications of MICA antibodies being associated with adverse graft outcome, to date a definitive consensus on this relationship has not been agreed. Because MICA molecules are not expressed constitutively on immunocompetent cells such as T and B lymphocytes, it is of utmost importance to address the impact of MICA donor specific antibodies (DSA) as compared to those that are non- donor specific (NDSA) on graft outcome. The soluble isoform of MICA molecule (sMICA) that is derived from the proteolytic shedding of membrane bound molecules has the potential to engage the NK-cell activating receptor NKG2D and down-regulate its expression. Consequent to the interaction of NKG2D by sMICA, the receptor ligand complex is endocytosed and degraded and thus suppresses NKG2D mediated lysis of the target by NK cells. Thus interaction between NKG2D and sMICA leads to expansion of immunosuppressive/anergic T cells thereby resulting in suppression of NKG2D mediated host innate immunity. These concept support the possible involvement of an immunosuppressive role for sMICA during allotransplantation as shown recently for heart transplantation. This research topic focuses on the clinical utility of investigating the complete antibody repertoire in solid organ transplantation.
    Keywords: R5-920 ; RC581-607 ; HLA matching ; donor specific antibodies ; antibody mediated rejection ; B cell immunity ; Graft outcome ; solid organ transplantation ; non HLA antibodies ; MICA antibodies ; antibody subclass ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
    Publication Date: 2022-09-01
    Description: The starting point for this project on the »Basic Questions of Tort Law« was the book written by Helmut Koziol, the »Basic Questions of Tort Law from a Germanic Perspective« (Sramek Verlag, 2012), a volume which presented an introduction into the law of torts from a Germanic perspective. Colleagues from seven countries were then invited to give critical responses to the ideas presented in the 2012 volume. The comparative law conclusions then attempt to pick up on the ideas expressed in the legal systems examined and to make them amenable for debate on the further development of the legal systems and their harmonisation. German Version: http://e-book.fwf.ac.at/o:603
    Description: Ausgangspunkt für das Projekt „Grundfragen des Schadenersatzrechts aus rechtsvergleichender Sicht“ war das von Helmut Koziol verfasste Buch „Grundfragen des Schadenersatzrechts“ (Sramek Verlag, 2010), welches eine Einführung in das Schadenersatzrecht des deutschsprachigen Raums darstellt. Vertreter aus sieben Ländern wurden gebeten, kritische Stellungnahmen zu den in diesem Buch erörterten Ideen abzugeben. Die daraus gewonnenen rechtsvergleichenden Schlussfolgerungen greifen die den behandelten Rechtsordnungen zugrunde liegenden Prinzipien auf und sollen diese damit einer Diskussion über die weitere Entwicklung und Harmonisierung der Rechtsordnungen zugänglich machen. Deutsche Version siehe: http://e-book.fwf.ac.at/o:603
    Keywords: Tort law, damages, contract law, comparative law, unjust enrichment, criminal law, insurance law, social security law, injunctions, economic analysis, prescription, basic questions, aims of tort law. ; Schadenersatzrecht, Vertragsrecht, Rechtsvergleichung, Bereicherungsrecht, Strafrecht, Versicherungsrecht, Sozialversicherungsrecht, einstweilige Verfügungen, ökonomische Analysen, Verjährung, Grundfragen, Prinzipien des Schadenersatzrechts ; bic Book Industry Communication::L Law
    Language: English
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  • 10
    Publication Date: 2023-12-21
    Description: In this Research Topic, we provide a comprehensive overview of current public health leadership research, focusing on understanding the impact of leadership on the delivery of public health services. By bringing together ground-breaking research studies detailing the development and validation of leadership activities and resources that promote effective public health practice in a variety of settings, we seek to provide a basis for leading public health organizations. We encouraged contributions that assess the effectiveness of public health leaders, as well as critical discussions of methods for improving the leadership of public health organizations at all levels. Both ongoing and completed original research was welcome, as well as methods, hypothesis and theory, and opinion papers. The effective practice of public health leadership is a key concept for public health practitioners to clearly understand as the 21st century unfolds. Following the significant lapses of leadership in the for-profit world, leaders in governmental and not-for-profit agencies are required to learn by their failed examples. A major task facing all current and prospective public health practitioners is developing the required leadership skills in order to be effective twenty first century leaders. As a consequence of the rapidly evolving health of the public, as well as the development of the discipline and practice of public health, understanding the principles and attributes of leadership are now required of all public health practitioners. Leadership can be described in a variety of ways. Leadership in public health requires skillful individuals meeting the health challenges of communities and the population as a whole. Leadership may be defined as a process that occurs whenever an individual intentionally attempts to influence another individual or group, regardless of the reason, in an effort to achieve a common goal which may or may not contribute to the success of the organization. Thus leadership is a process involving two or more people. The nature of leadership is an important aspect of the concept as a whole. Submissions relating public health leadership to the management of public health organizations were welcomed. This Research Topic provided the opportunity for authors to consider the concept of leadership from a variety of approaches. Original research papers considering a variety of leadership theories provide methodological approaches to the topic. Hypothesis and theory papers provide the basis for application of leadership to public health practice. Opinion papers provide the opportunity to develop thinking concerning practice of public health leadership.
    Keywords: R5-920 ; RA1-1270 ; Leadership ; Leading People ; public health accreditation ; Conditions of Trust ; Managing Organizations ; openness to change ; situational leadership ; Full Range Leadership ; Management ; leadership ethics ; bic Book Industry Communication::M Medicine
    Language: English
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