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  • 2020-2024  (5)
  • 2010-2014
  • 1985-1989
  • 2021  (5)
  • 1
    Publication Date: 2021-12-01
    Print ISSN: 0306-2619
    Electronic ISSN: 1872-9118
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Elsevier
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  • 2
    Publication Date: 2021-10-28
    Description: C-reactive protein (CRP) is an acute-phase protein in humans that is produced in high quantities by the liver upon infection and under inflammatory conditions. Although CRP is commonly used as a marker of inflammation, CRP can also directly contribute to inflammation by eliciting pro-inflammatory cytokine production by immune cells. Since CRP is highly elevated in serum under inflammatory conditions, we have studied the CRP-induced cytokine profile of human monocytes, one of the main innate immune cell populations in blood. We identified that CRP is relatively unique in its capacity to induce production of the pro-inflammatory cytokine IL-23, which was in stark contrast to a wide panel of pattern recognition receptor (PRR) ligands. We show that CRP-induced IL-23 production was mediated at the level of gene transcription, since CRP particularly promoted gene transcription of IL23A (encoding IL-23p19) instead of IL12A (encoding IL-12p35), while PRR ligands induce the opposite response. Interestingly, when CRP stimulation was combined with PRR ligand stimulation, as for example, occurs in the context of sepsis, IL-23 production by monocytes was strongly reduced. Combined, these data identify CRP as a unique individual ligand to induce IL-23 production by monocytes, which may contribute to shaping systemic immune responses under inflammatory conditions.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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  • 3
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    KIT Scientific Publishing
    Publication Date: 2023-07-05
    Description: The second French-German workshop about Consumer Empowerment took place at the University of Karlsruhe (KIT) between January 10-11, 2013. Within the scope of consumer empowerment scientists discussed recent developments in this field and established cross-disciplinary coop- erations in their own fields of research.
    Keywords: HF5001-6182 ; empowerment ; Co-creationConsumer ; enablement ; co-creation ; Enablement ; Sharing ; Konsument ; sharing ; Empowerment
    Language: English
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  • 4
    Publication Date: 2024-03-25
    Description: Ce quatrième ouvrage de la série « Conquête de la steppe » présente de nouvelles études d’archéologie, de géoarchéologie et d’anthropologie issues d’un important programme de prospection de la zone steppique de la Syrie centrale à l’est de Hama, qui s’est déroulé de 1995 à 2010. Les périodes dont il est question ici vont du PPNB à l’époque contemporaine (VIIIe millénaire av. J.-C.-xxie s. ap. J.-C.). L’adaptation de l’homme à l’environnement est abordée du point de vue de l’acquisition et du stockage de l’eau en milieu aride, grâce aux citernes pluviales, et à travers deux études de cas : celle d’un village du PPNB et celle de deux années pluviométriques extrêmes. Une partie des articles (céramique, monnaies, monuments religieux) éclaire d’un nouveau jour la définition du territoire régional, durant l’Antiquité et par la suite. Des questions de topographie historique sont aussi abordées grâce à la publication de nouvelles inscriptions. Enfin, plusieurs contributions concernent les formes de l’habitat, aussi bien les résidences luxueuses des propriétaires terriens (des époques omeyyade et contemporaine) que les villages byzantins et les processus de sédentarisation à l’époque contemporaine.
    Keywords: D1-2009 ; monastery ; housing ; water management ; archaeology ; climate ; residence ; nomad ; pottery (ceramics) ; Arid Margins ; geoarchaeology ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 5
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    Peter Lang International Academic Publishing Group
    Publication Date: 2024-03-26
    Description: 2012 wurde das Netzwerk-Projekt «Landeskunde Nord» ins Leben gerufen, dessen Ziel es ist, Forschung und Lehre zur Landeskunde des Deutschen als Fremdsprache, insbesondere in den nordischen Ländern, voranzutreiben. Dieses Buch knüpft an die bereits erschienenen Bände «Landeskunde Nord» beziehungsweise «Perspektive Nord» an und bietet weitere Reflexionen wissenschaftstheoretischer, fachdidaktischer und inhaltlicher Aspekte, die für die Gestaltung der landeskundlichen Lehre und des landeskundlichen Unterrichts relevant erscheinen. In ihrer Vielfalt schlagen die Konzepte und Ideen des Bandes Brücken zu Literatur- und Sprachwissenschaft sowie zu den Sozial- und Kulturwissenschaften. Die Beiträge nehmen international geführte Fachdiskussionen auf und haben auch deshalb über die nordischen Länder hinaus Bedeutung.
    Keywords: Beiträge ; Deutsch als Fremdsprache ; Didaktik der Landeskunde ; Frank ; Germanistik ; Geyer ; Grub ; Hochschullehre ; Inhalte ; Interkulturelle Kompetenz ; Januar ; Klaus ; Konferenz ; Landeskunde ; Methoden ; Netzwerks ; Nord ; Odense ; Spektrum ; Thomas ; Unterricht ; Vielfalt ; Ziele ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: German
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