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  • 1
    Publication Date: 2023-12-21
    Description: Carbohydrates are extremely abundant bio-molecules; they are on all mammalian cell surfaces as well as on bacterial cell surfaces. In mammals most secreted proteins are glycosylated, with the glycan component comprising a significant amount by mass of the glycoprotein. Although, many years ago carbohydrate-protein recognition events were demonstrated as involved in invertebrate self-non self recognition, the contribution of carbohydrate-protein binding events to the mechanisms of the mammalian immune response was not embraced with the same enthusiasm. Adaptive immunity and the contribution of antibodies, T cells and T-lymphocyte sub-sets and protein antigen presentation dominated immunological theory. Unlike protein structures, carbohydrate structures are not template driven yet the numerous enzymes involved in carbohydrate biosynthesis and modification are encoded by a major component of the genome, and the expression of these enzymes is tightly regulated. As a consequence carbohydrate structures are also regulated, with different structures appearing according to the stage of cell differentiation and according to the age or health of the individual. The advent of technologies that have allowed carbohydrate structures and carbohydrate-protein binding events to be more easily interrogated has resulted in these types of interactions taking their place in modern immunology. We now know that glycans and their ligands (or lectins) are involved in numerous immunological pathways of both the innate and adaptive systems. However, it is clear that our understanding is still in its infancy, as more and more examples where carbohydrate structures contribute to aspects of the immune response are being recognised. The goal of this research topic is to explore the variety of roles undertaken by glycans and lectins in all aspects of the immune response. The particular focus is how the interactions of glycans with their ligands contribute to the mechanism of immune responses.
    Keywords: R5-920 ; RC581-607 ; Heparan sulfate ; Siglec ; HIV ; sialic acid ; hyaluronan ; galectin ; Heparanase ; Inflammation ; glycosaminoglycan ; Glycan ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.
    Keywords: R5-920 ; RC581-607 ; B cell ; PI3K/AKT/mTOR ; Signal Transduction ; T cell ; PI3K pathway inhibitors ; bic Book Industry Communication::M Medicine
    Language: English
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  • 5
    Publication Date: 2023-12-21
    Description: Venous thromboembolism (VTE) occurs less often in children than adults and therefore remains underrecognized despite increasing in incidence. Due to the risk of mortality, short- and long-term morbidity, and increased healthcare costs associated with pediatric VTE, this entity merits better understanding and consideration. With this Research Topic, we aim to highlight some special considerations of pediatric VTE, namely risk factors and epidemiology, rare types of pediatric thrombosis and considerations unique to specific clinical patient subgroups, approaches to management and treatment, and prevention
    Keywords: R5-920 ; RJ1-570 ; Pediatrics ; Venous Thromboembolism ; Treatment ; Management ; Thrombosis ; Epidemiology ; Risk factors ; prevention ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
    Publication Date: 2023-12-21
    Description: Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.
    Keywords: R5-920 ; QH301-705.5 ; RC254-282 ; Q1-390 ; microenvironment ; Stem Cells ; hypoxia ; stress ; HIF ; tumor ; Leukemia ; biomarkers ; therapy ; pH ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
    Publication Date: 2023-12-21
    Description: The Halophiles 2013 meeting is a multidisciplinary international congress, with a strong history of regular triennial meetings since 1978. Our mission is to bring researchers from a wide diversity of investigation interests (e.g., protein and species evolution; niche adaptation, ecology, taxonomy, genomics, metagenomics, horizontal gene transfer, gene regulation; DNA replication, repair and recombination; signal transduction; community assembly and species distribution; astrobiology; biotechnological applications; adaptation to radiation, desiccation, osmotic stress) into a single forum for the integration and synthesis of ideas and data from all three domains of life, and their viruses, yet from a single environment; salt concentrations greater than seawater. This cross-section of research informs our understanding of the microbiological world in many ways. The halophilic environment is extreme, especially above 10% NaCl, restricting life solely to microbes. The microorganisms that live there are adapted to extreme conditions, and are notable for their ability to survive high doses of radiation and desiccation. Therefore, the hypersaline environment is a model system (both the abiotic, and biologic factors) for insightful understanding regarding conditions and life in the absence of plant and animals (e.g., life on the early earth, and other solar system bodies like Mars and Europa). Lower salinity conditions (e.g., 6-10% NaCl) form luxuriant microbial mats considered modern analogues of fossilized stromatolites, which are enormous microbially produced structures fashioned during the Precambrian (and still seen today in places like Shark’s Bay, Australia). Hypersaline systems are island-like habitats spread patchily across the earth’s surface, and similar to the Galapagos Islands represent unique systems excellent for studying the evolutionary pressures that shape microbial community assembly, adaptation, and speciation. The unique adaptations to this extreme environment produce valuable proteins, enzymes and other molecules capable of remediating harsh human instigated environments, and are useful for the production of biofuels, vitamins, and retinal implants, for example. This research topic is intended to capture the breadth and depth of these topics.
    Keywords: R5-920 ; RC254-282 ; halophile evolution ; halophilic and halotolerant microorganisms ; Haloferax volcanii ; halophile biochemistry ; halophile metabolism ; halophile adaptations ; halophile molecular biology ; halophile communities ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
    Publication Date: 2023-12-21
    Description: Immune privilege was once thought to be the property of a few select sites that include the eye, brain, testis, pregnant uterus and (of all things) the hamster cheek pouch, and was believed to be mainly based on sequestration behind blood-tissue barriers. This view has changed. Immune privilege is now considered to constitute a more general phenomenon through which tissues are able to actively direct and control immune responses taking place in their “territory” to preserve their structural and functional integrity in the face of inflammatory processes. These positive aspects of immune privilege can be hijacked by tumors to their survival advantage and to the detriment of the host. This Research Topic dissects the beneficial and deleterious consequences of immune privilege in terms of the cellular and molecular mechanisms that various tissues and tumors use, each in its own fashion, to regulate immune processes that affect them, at the local and the systemic level.
    Keywords: R5-920 ; RC581-607 ; Eye ; Immune Privilege ; immune suppression ; tolerance ; regulatory cells ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes.
    Keywords: R5-920 ; RC346-429 ; n/a ; analgesia ; quantitative phosphoproteomics ; neurodegeneration ; neuron ; neuronal circuits ; mating ; sex-specific differences ; AMPA receptor complex ; parallel reaction monitoring ; splicing ; phosphorylation ; peptidylglycine ?-amidating monooxygenase ; pherophorin ; Alzheimer’s disease ; neuroscience ; yohimbine ; synapses ; adolescence ; conformational antibody ; opioid receptors ; protein interaction networks ; Alzheimer’s Disease ; transmembrane AMPA receptor regulatory protein ; neuroproteome ; ethanol ; U1 snRNP ; mass spectroscopy ; morphine ; protein phosphatase-1 ; neuroproteomics ; axons ; reinstatement ; DIA ; voltage gated channels ; prohormone convertase ; postsynaptic density ; neuroimmune ; dendrites ; carboxypeptidase ; GPCR signaling ; CaMKII ; FGF14 ; SynCAM ; nicotinic receptor ; synaptic plasticity ; plasma ; serum ; corticosterone ; dopamine ; Receptor-type tyrosine-protein phosphatase zeta ; Ptprz1 ; PRM ; cell type ; schizophrenia ; laser capture microdissection ; synapse specificity ; LC-MS/MS ; mouse ; drug abuse ; synaptic cleft ; striatum ; Cadm ; cytokine ; spinophilin ; PSD ; trans-synaptic adhesion ; nicotine ; proximity labeling ; biomarkers ; addiction ; PKA ; synapse ; proteome ; signal peptide ; ventral tegmental area ; protein aggregation ; cerebrospinal fluid ; bioinformatics ; progressive ratio ; interactome ; subtilisin ; affinity chromatography ; basal ganglia ; cocaine ; targeted proteomics ; postsynaptic ; mass spectrometry ; connectome ; quantitative mass spectrometry ; biotinylation ; proteomics ; amphetamine ; autism ; data-independent acquisition ; excitatory/inhibitory tone ; neuropeptidomics ; matrix metalloproteinase ; cilia ; R-PTP-zeta ; cognitive impairment
    Language: English
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  • 10
    Publication Date: 2023-12-21
    Description: Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
    Keywords: R5-920 ; RM1-950 ; RC254-282 ; Q1-390 ; toxicity ; cancer treatment ; antineoplastic drugs ; adverse effects ; chemotherapy ; bic Book Industry Communication::M Medicine
    Language: English
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