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  • 1
    Keywords: mass movements; landslides
    Description / Table of Contents: Introduction --- Subaqueous mass movements in the context of observations of contemporary slope failure / Joshu J. Mountjoy, Aggeliki Georgiopoulou, Jason Chaytor, Michael A. Clare, Davide Gamboa and Jasper Moernaut / Geological Society, London, Special Publications, 500, 1-12, 26 May 2020, https://doi.org/10.1144/SP500-2019-237 --- Section A: consequences and implications --- Revisiting the tsunamigenic volcanic flank collapse of Fogo Island in the Cape Verdes, offshore West Africa / Rachel Barrett, Elodie Lebas, Ricardo Ramalho, Ingo Klaucke, Steffen Kutterolf, Andreas Klügel, Katja Lindhorst, Felix Gross and Sebastian Krastel / Geological Society, London, Special Publications, 500, 13-26, 13 March 2020, https://doi.org/10.1144/SP500-2019-187 --- The sedimentology and tsunamigenic potential of the Byron submarine landslide off New South Wales, Australia / Kendall C. Mollison, Hannah E. Power, Samantha L. Clarke, Alan T. Baxter, Emily M. Lane and Thomas C. T. Hubble / Geological Society, London, Special Publications, 500, 27-40, 7 April 2020, https://doi.org/10.1144/SP500-2019-160 --- Effects of rotational submarine slump dynamics on tsunami genesis: new insight from idealized models and the 1929 Grand Banks event / T. Zengaffinen, F. Løvholt, G. K. Pedersen and C. B. Harbitz / Geological Society, London, Special Publications, 500, 41-61, 11 May 2020, https://doi.org/10.1144/SP500-2019-201 --- A scenario-based assessment of the tsunami hazard in Palermo, northern Sicily, and the southern Tyrrhenian Sea / Jack Dignan, Aaron Micallef, Christof Mueller, Attilio Sulli, Elisabetta Zizzo and Daniele Spatola / Geological Society, London, Special Publications, 500, 63-80, 31 March 2020, https://doi.org/10.1144/SP500-2019-181 --- A workflow for the rapid assessment of the landslide-tsunami hazard in peri-alpine lakes / Michael Strupler, Flavio S. Anselmetti, Michael Hilbe, Katrina Kremer and Stefan Wiemer / Geological Society, London, Special Publications, 500, 81-95, 18 March 2020, https://doi.org/10.1144/SP500-2019-166 --- Towards a national-scale assessment of the subaqueous mass movement hazard in Canada / D. Gwyn Lintern, Jessica Rutherford, Philip R. Hill, Calvin Campbell and Alexandre Normandeau / Geological Society, London, Special Publications, 500, 97-113, 11 May 2020, https://doi.org/10.1144/SP500-2019-206 --- Structural constraints on the subduction of mass-transport deposits in convergent margins / Jacob Geersen, Andrea Festa and Francesca Remitti / Geological Society, London, Special Publications, 500, 115-128, 13 March 2020, https://doi.org/10.1144/SP500-2019-174 --- Evaluating the sealing potential of young and thin mass-transport deposits: Lake Villarrica, Chile / Jasper Moernaut, Gauvain Wiemer, Achim Kopf and Michael Strasser / Geological Society, London, Special Publications, 500, 129-146, 13 March 2020, https://doi.org/10.1144/SP500-2019-155 --- Influence of mass transport deposit (MTD) surface topography on deep-water deposition: an example from a predominantly fine-grained continental margin, New Zealand / Suzanne Bull, Greg H. Browne, Malcolm J. Arnot and Lorna J. Strachan / Geological Society, London, Special Publications, 500, 147-171, 28 April 2020, https://doi.org/10.1144/SP500-2019-192 --- Section B: initiation, triggers and preconditioning --- A multi-disciplinary investigation of the AFEN Slide: the relationship between contourites and submarine landslides / Ricarda Gatter, Michael A. Clare, James E. Hunt, Millie Watts, B. N. Madhusudhan, Peter J. Talling and Katrin Huhn / Geological Society, London, Special Publications, 500, 173-193, 28 April 2020, https://doi.org/10.1144/SP500-2019-184 --- Indonesian Throughflow as a preconditioning mechanism for submarine landslides in the Makassar Strait / Rachel E. Brackenridge, Uisdean Nicholson, Benyamin Sapiie, Dorrik Stow and Dave R. Tappin / Geological Society, London, Special Publications, 500, 195-217, 1 April 2020, https://doi.org/10.1144/SP500-2019-171 --- Morphological signature of gully development by rapid slide retrogression in a layered coarse-grained delta foreslope / Jacques Locat, Ali Azizian, Jim Stronach, Aurélien Hospital, Chris Young, Dominique Turmel and Andrew Bevan / Geological Society, London, Special Publications, 500, 219-234, 13 March 2020, https://doi.org/10.1144/SP500-2019-159 --- Morphology and spatio-temporal distribution of lacustrine mass-transport deposits in Wörthersee, Eastern Alps, Austria / Christoph Daxer, Maddalena Sammartini, Ariana Molenaar, Thomas Piechl, Michael Strasser and Jasper Moernaut / Geological Society, London, Special Publications, 500, 235-254, 19 March 2020, https://doi.org/10.1144/SP500-2019-179 --- A numerical investigation of excess pore pressures and continental slope stability in response to ice-sheet dynamics / Morelia Urlaub, Isabel Kratzke and Berit Oline Hjelstuen / Geological Society, London, Special Publications, 500, 255-266, 13 March 2020, https://doi.org/10.1144/SP500-2019-185 --- Impact of sea-level fluctuations on the sedimentation patterns of the SE African margin: implications for slope instability / Aaron Micallef, Aggeliki Georgiopoulou, Andrew Green and Vittorio Maselli / Geological Society, London, Special Publications, 500, 267-276, 13 March 2020, https://doi.org/10.1144/SP500-2019-172 --- Geomechanical behaviour of gassy soils and implications for submarine slope stability: a literature analysis / P. Kaminski, M. Urlaub, J. Grabe and C. Berndt / Geological Society, London, Special Publications, 500, 277-288, 13 March 2020, https://doi.org/10.1144/SP500-2019-149 --- From gravity cores to overpressure history: the importance of measured sediment physical properties in hydrogeological models / Davide Mencaroni, Jaume Llopart, Roger Urgeles, Sara Lafuerza, Eulàlia Gràcia, Anne Le Friant and Morelia Urlaub / Geological Society, London, Special Publications, 500, 289-300, 22 May 2020, https://doi.org/10.1144/SP500-2019-176 --- The influence of clay content on submarine slope failure: insights from laboratory experiments and numerical models / M. M. W. Silver and B. Dugan / Geological Society, London, Special Publications, 500, 301-309, 26 March 2020, https://doi.org/10.1144/SP500-2019-186 --- Subduction of an extinct rift and its role in the formation of submarine landslides in NW South America / Carlos A. Vargas, Gustavo A. Gutiérrez and Gustavo A. Sarmiento / Geological Society, London, Special Publications, 500, 311-322, 12 May 2020, https://doi.org/10.1144/SP500-2019-189 --- Section C: characterization and regional controls --- Mass wasting on Alpha Ridge in the Arctic Ocean: new insights from multibeam bathymetry and sub-bottom profiler data / Kai Boggild, David C. Mosher, Paola Travaglini, Catalina Gebhardt and Larry Mayer / Geological Society, London, Special Publications, 500, 323-340, 13 May 2020, https://doi.org/10.1144/SP500-2019-196 --- The Last Glacial Maximum Balearic Abyssal Plain megabed revisited / Antonio Cattaneo, Shray Badhani, Cristina Caradonna, Massimo Bellucci, Estelle Leroux, Nathalie Babonneau, Sébastien Garziglia, Jeffrey Poort, Grigorii G. Akhmanov, Germain Bayon, Bernard Dennielou, Gwenäel Jouet, Sébastien Migeon, Marina Rabineau, Laurence Droz and Michael Clare / Geological Society, London, Special Publications, 500, 341-357, 14 May 2020, https://doi.org/10.1144/SP500-2019-188 --- Integrated geophysical, sedimentological and geotechnical investigation of submarine landslides in the Gulf of Lions (Western Mediterranean) / Shray Badhani, Antonio Cattaneo, Stefano Collico, Roger Urgeles, Bernard Dennielou, Estelle Leroux, Florent Colin, Sebastien Garziglia, Marina Rabineau and Laurence Droz / Geological Society, London, Special Publications, 500, 359-376, 14 May 2020, https://doi.org/10.1144/SP500-2019-175 --- Characterization of recent deep-sea debrites in the eastern Mediterranean based on foraminiferal taphonomy / Oded Katz, Leeron Ashkenazi, Shani Sultan-Levi, Sigal Abramovich, Ahuva Almogi-Labin and Orit Hyams-Kaphzan / Geological Society, London, Special Publications, 500, 377-391, 11 May 2020, https://doi.org/10.1144/SP500-2019-170 --- Widespread mass-wasting processes off NE Sicily (Italy): insights from morpho-bathymetric analysis / Daniele Casalbore, Romano Clementucci, Alessandro Bosman, Francesco Latino Chiocci, Eleonora Martorelli and Domenico Ridente / Geological Society, London, Special Publications, 500, 393-403, 15 May 2020, https://doi.org/10.1144/SP500-2019-195 --- Geomorphology and event-stratigraphy of recent mass-movement processes in Lake Hallstatt (UNESCO World Heritage Cultural Landscape, Austria) / Michael Strasser, T. Berberich, S. Fabbri, M. Hilbe, J-J. S. Huang, S. Lauterbach, M. Ortler, H. Rechschreiter, A. Brauer, F. Anselmetti and K. Kowarik / Geological Society, London, Special Publications, 500, 405-426, 31 March 2020, https://doi.org/10.1144/SP500-2019-178 --- Slope stability hazard in a fjord environment: Douglas Channel, Canada / Cooper D. Stacey, D. Gwyn Lintern, John Shaw and Kim W. Conway / Geological Society, London, Special Publications, 500, 427-451, 20 May 2020, https://doi.org/10.1144/SP500-2019-191 --- Submarine canyons, slope failures and mass transport processes in southern Cascadia / Jenna C. Hill, Janet T. Watt, Daniel S. Brothers and Jared W. Kluesner / Geological Society, London, Special Publications, 500, 453-475, 20 May 2020, https://doi.org/10.1144/SP500-2019-169 --- Tectonic and geomorphic controls on the distribution of submarine landslides across active and passive margins, eastern New Zealand / S. J. Watson, J. J. Mountjoy and G. J. Crutchley / Geological Society, London, Special Publications, 500, 477-494, 13 March 2020, https://doi.org/10.1144/SP500-2019-165 --- Geological and tectonic controls on morphometrics of submarine landslides of the Spanish margins / Ricardo León, Roger Urgeles, Raul Pérez-López, Emilio Payo, Amanda Vázquez-Izquierdo, Carmen Julia Giménez-Moreno and David Casas / Geological Society, London, Special Publications, 500, 495-513, 20 May 2020, https://doi.org/10.1144/SP500-2019-153 --- Section D: mobility and kinematics --- Megaclasts within mass-transport deposits: their origin, characteristics and effect on substrates and succeeding flows / Jefferson Nwoko, Ian Kane and Mads Huuse / Geological Society, London, Special Publications, 500, 515-530, 31 March 2020, https://doi.org/10.1144/SP500-2019-146 --- Line length balancing to evaluate multi-phase submarine landslide development: an example from the Storegga Slide, Norway / Suzanne Bull and Joseph A. Cartwright / Geological Society, London, Special Publications, 500, 531-549, 23 March 2020, https://doi.org/10.1144/SP500-2019-168 --- A new depositional model for the Tuaheni Landslide Complex, Hikurangi Margin, New Zealand / Benjamin Couvin, Aggeliki Georgiopoulou, Joshu J. Mountjoy, Lawrence Amy, Gareth J. Crutchley, Morgane Brunet, Sebastian Cardona, Felix Gross, Christoph Böttner, Sebastian Krastel and Ingo Pecher / Geological Society, London, Special Publications, 500, 551-566, 19 May 2020, https://doi.org/10.1144/SP500-2019-180 --- Mass transport deposits in the Donegal Barra Fan and their association with British–Irish Ice Sheet dynamics / Srikumar Roy, Aggeliki Georgiopoulou, Sara Benetti and Fabio Sacchetti / Geological Society, London, Special Publications, 500, 567-586, 18 March 2020, https://doi.org/10.1144/SP500-2019-177 --- Short- and long-term movement of mudflows of the Mississippi River Delta Front and their known and potential impacts on oil and gas infrastructure / Jason D. Chaytor, Wayne E. Baldwin, Samuel J. Bentley, Melanie Damour, Douglas Jones, Jillian Maloney, Michael D. Miner, Jeff Obelcz and Kehui Xu / Geological Society, London, Special Publications, 500, 587-604, 26 March 2020, https://doi.org/10.1144/SP500-2019-183 --- Lessons learned from the monitoring of turbidity currents and guidance for future platform designs / Michael Clare, D. Gwyn Lintern, Kurt Rosenberger, John E. Hughes Clarke, Charles Paull, Roberto Gwiazda, Matthieu J. B. Cartigny, Peter J. Talling, Daniel Perara, Jingping Xu, Daniel Parsons, Ricardo Silva Jacinto and Ronan Apprioual / Geological Society, London, Special Publications, 500, 605-634, 22 May 2020, https://doi.org/10.1144/SP500-2019-173
    Pages: Online-Ressource (VII, 639 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781786204776
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 3
    Keywords: Conservation biology. ; Ecology . ; Biotic communities. ; Population biology. ; Animal migration. ; Conservation Biology. ; Theoretical and Statistical Ecology. ; Community and Population Ecology. ; Animal Migration.
    Description / Table of Contents: Chapter 1. The conservation issue -- Chapter 2. Development of hierarchical spatial models for assessing ungulate abundance and habitat relationships -- Chapter 3. Model-based assessment of ungulate-habitat relationships -- Chapter 4. Assessing threats to ungulates and management responses -- Chapter 5. Conservation of tropical forest ungulates: the way forward.
    Abstract: Large ungulates in tropical forests are among the most threatened taxa of mammals. Excessive hunting, degradation of and encroachments on their natural habitats by humans have contributed to drastic reductions in wild ungulate populations in recent decades. As such, reliable assessments of ungulate-habitat relationships and the spatial dynamics of their populations are urgently needed to provide a scientific basis for conservation efforts. However, such rigorous assessments are methodologically complex and logistically difficult, and consequently many commonly used ungulate population survey methods do not address key problems. As a result of such deficiencies, key parameters related to population distribution, abundance, habitat ecology and management of tropical forest ungulates remain poorly understood. This book addresses this critical knowledge gap by examining how population abundance patterns in five threatened species of large ungulates vary across space in the tropical forests of the Nagarahole-Bandipur reserves in southwestern India. It also explains the development and application of an innovative methodology – spatially explicit line transect sampling – based on an advanced hierarchical modelling under the Bayesian inferential framework, which overcomes common methodological deficiencies in current ungulate surveys. The methods and results presented provide valuable reference material for researchers and professionals involved in studying and managing wild ungulate populations around the globe. .
    Type of Medium: Online Resource
    Pages: XXVII, 195 p. 46 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811569340
    DDC: 333.9516
    Language: English
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  • 4
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    DDC: 571.978
    Language: English
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  • 5
    Keywords: Cytology. ; Neurosciences. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer. ; Cell Biology. ; Neuroscience. ; Immunology. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.
    Abstract: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
    Type of Medium: Online Resource
    Pages: XII, 348 p. 42 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382667
    Series Statement: Advances in Experimental Medicine and Biology, 1233
    DDC: 571.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Endocrine glands. ; Neuroscience. ; Endocrine System.
    Description / Table of Contents: Photoperiodism and Circannual Timing: Introduction and Historical Perspective.-The Pars Tuberalis and Seasonal Timing -- Tanycytes and Their Pivotal Role in Seasonal Physiological Adaptations -- Epigenetic Mechanisms in Developmental and Seasonal Programs -- Plasticity of Neuroendocrine Mechanisms Regulating Seasonal Reproduction in Sheep -- Clocks and Calendrars in Birds -- Calendar Timing in Teleost Fish -- Action of Light on the Neuroendocrine Axis -- Seasons, Clocks, and Mood -- Photoperiodic Modulation of Clock Gene Expression in the SCN -- Circadian Timekeeping in the Suprachiasmatic Nucleus: Genes, Neurotransmitters, Neurons and Astrocytes. .
    Abstract: This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of “clock“ gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. .
    Type of Medium: Online Resource
    Pages: XII, 244 p. 64 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030556433
    Series Statement: Masterclass in Neuroendocrinology, 10
    DDC: 612.8
    Language: English
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  • 7
    Keywords: Nervous system Surgery. ; Radiology. ; Biophysics. ; Nervous system Radiography. ; Neurology . ; Neurosciences. ; Neurosurgery. ; Radiology. ; Biophysics. ; Neuroradiology. ; Neurology. ; Neuroscience.
    Description / Table of Contents: Foreword -- Preface -- Introduction -- 1. Physics and radiation dosage issues in neuroradiosurgical treatment of meningiomas -- 2. Imaging Approaches for radiosurgical treatment of Meningiomas -- 3. MEDICAL MANAGEMENT OF MENINGIOMAS -- 4. Systemic Treatments for Grade II and III Meningiomas (WHO) -- 5. Gamma Knife Radiosurgery for Posterior Cranial Fossa Meningioma -- 6. Stereotactic Radiosurgery for Cavernous Sinus Meningiomas -- 7. Hypofractionated radiosurgery for perioptic meningiomas: Current practice, principles and treatment quandary -- 8. Hypofractionation and normofractionation in Skull Base Meningiomas -- 9. Atypical and anaplastic meningiomas: is there a role for stereotactic radiosurgery? -- 10. CyberKnife Treatment of Atypical Meningiomas (GII) -- 11. SRS & Microsurgery: antagonistic or complementary in the treatment of meningiomas? -- 12. Combined microsurgical and radiosurgical treatment in intracranial meningiomas -- 13. SRS in Incidental Meningioma: Whether to Treat and When -- 14. Side-effects of SRS treatment of low-grade meningioma: types, frequency and management -- 15. Single- and Multiple-Session Radiosurgery for Spinal Meningioma: Radiosurgery for spinal meningioma -- 16. Guidelines and evidence-based recommendations for the radiosurgical treatment of CNS meningiomas.
    Abstract: Meningiomas are the most frequently reported neuro-oncologic condition, accounting for 12% to 30% of all primary intracranial tumors. The first case of intracranial meningioma treated with stereotactic radiosurgery was reported by Backlund E-O in 1971. Since then, more than 200,000 meningiomas have been treated with stereotactic radiosurgery worldwide to date. The large number of patients treated using this method is due to the fact that meningiomas are frequently located in critical areas and microsurgery is often associated with severe and permanent neurological complications. This book discusses the advantages, risks and limits of stereotactic radiosurgery relating to all regions of interest for a neuroradiosurgical approach for the treatment of central nervous system meningiomas. Firstly, it presents an introduction focusing on the “state of the art”. It then discusses the physics, imaging, neurological and neuro-oncological issues in multidisciplinary management. Lastly, it features a summary of results, including the most recent published papers regarding all the locations involved in the stereotactic radiosurgery treatment as well as new approaches to meningiomas, with particular reference to the hypofrationated treatments. Intended for anyone involved in the neuroradiosurgical treatment of brain diseases, the book provides an up-to-date overview of the latest stereotactic radiosurgery treatment of central nervous system meningiomas.
    Type of Medium: Online Resource
    Pages: X, 160 p. 30 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030794194
    DDC: 617.48
    Language: English
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  • 8
    Keywords: Embryology. ; Vertebrates. ; Physiology. ; Anatomy, Comparative. ; Reproductive health. ; Veterinary medicine. ; Embryology. ; Vertebrate Zoology. ; Animal Physiology. ; Animal Anatomy. ; Reproductive Medicine. ; Veterinary Science.
    Description / Table of Contents: Mammalian Placentation: A Tribute to E.C. Amoroso’s Contributions to Placenta Development -- The Evolution of Viviparity in Vertebrates -- Development of Pre-Implantation Mammalian Blastocyst -- Placentation in Marsupials -- The Early Stages of Implantation and Placentation in the Pig -- Placentation in Equids -- Implantation and Placentation in Ruminants -- Canine Endotheliochorial Placenta - Morpho-Functional Aspects -- Placentation in The African Elephant (Loxodonta Africana) -- Development of the Mouse Placenta -- Placentation in the Human hnd Higher Primates.
    Abstract: The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy. Development of viviparity and placentation in rodents, dogs, pigs, cattle, horses, marsupials, primates and elephants are discussed. The development of viviparity in mammals, including some invertebrate species, required the adaptation of the placenta to serve as a functional conduit for interplay between the semiallograftic fetus with the maternal uterus. Although the ‘placenta’ protects the fetus from maternal immune rejection and provides oxygen and nutrient flow to support it to term across all the species, structural differentiation of this fetal-maternal interface can vary from simple to very complex. E.C. Amoroso contributed greatly to our early understanding and knowledge of placentation across a great variety of species. His work on placentation provides numerous illustrations and histological sections which are used for teaching and stimulating research today. With this book, we want to pay tribute to his lifetime contributions to the field by reviewing our current understanding of the development of viviparity and placentation in different species. The book is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in placentation and viviparity.
    Type of Medium: Online Resource
    Pages: XII, 254 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030773601
    Series Statement: Advances in Anatomy, Embryology and Cell Biology, 234
    DDC: 571.86
    Language: English
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  • 9
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    DDC: 615
    Language: English
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  • 10
    Keywords: Ecology . ; Biotic communities. ; Pollution. ; Water. ; Hydrology. ; Ecology. ; Ecosystems. ; Pollution. ; Water.
    Abstract: This book is the final installation in a three-volume series synthesizing 30 years of mercury research in the Florida Everglades. The first part of this book evaluates the occurrence of trends in both biota mercury concentrations and atmospheric mercury deposition. Through both empirical and deterministic analyses, the likely drivers of biota trends are identified. These analyses help lay the predicate for devising an overall strategy to mitigate and manage the Everglades mercury problem. The book concludes with a model analysis of the likely benefits and uncertainty attendant with implementing the leading candidate strategy for best reducing the Everglades mercury problem.
    Type of Medium: Online Resource
    Pages: XV, 164 p. 78 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030556358
    DDC: 577
    Language: English
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