ALBERT

Description: Obstructive sleep apnea (OSA) causes many systemic disorders via mechanisms related to sympathetic nerve activation, systemic inflammation, and oxidative stress. OSA typically shows repeated sleep apnea followed by hyperventilation, which results in intermittent hypoxia (IH). IH is associated with an increase in sympathetic activity, which is a well-known pathophysiological mechanism in hypertension and insulin resistance. In this review, we show the basic and clinical significance of IH from the viewpoint of not only systemic regulatory mechanisms focusing on pulmonary circulation, but also cellular mechanisms causing lifestyle-related diseases. First, we demonstrate how IH influences pulmonary circulation to cause pulmonary hypertension during sleep in association with sleep state-specific change in OSA. We also clarify how nocturnal IH activates circulating monocytes to accelerate the infiltration ability to vascular wall in OSA. Finally, the effects of IH on insulin secretion and insulin resistance are elucidated by using an in vitro chamber system that can mimic and manipulate IH. The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic β cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-α, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Clinical and experimental findings concerning IH give us productive new knowledge of how lifestyle-related diseases and pulmonary hypertension develop during sleep.

Description: Obstructive sleep apnea (OSA) causes many systemic disorders via mechanisms related to sympathetic nerve activation, systemic inflammation, and oxidative stress. OSA typically shows repeated sleep apnea followed by hyperventilation, which results in intermittent hypoxia (IH). IH is associated with an increase in sympathetic activity, which is a well-known pathophysiological mechanism in hypertension and insulin resistance. In this review, we show the basic and clinical significance of IH from the viewpoint of not only systemic regulatory mechanisms focusing on pulmonary circulation, but also cellular mechanisms causing lifestyle-related diseases. First, we demonstrate how IH influences pulmonary circulation to cause pulmonary hypertension during sleep in association with sleep state-specific change in OSA. We also clarify how nocturnal IH activates circulating monocytes to accelerate the infiltration ability to vascular wall in OSA. Finally, the effects of IH on insulin secretion and insulin resistance are elucidated by using an in vitro chamber system that can mimic and manipulate IH. The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic β cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-α, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Clinical and experimental findings concerning IH give us productive new knowledge of how lifestyle-related diseases and pulmonary hypertension develop during sleep.

Description: The tank cascade system (TCS) has been used for over 2000 years for water management in Sri Lanka. Since surface water is limited in the dry zone of Sri Lanka, agricultural production, especially of upland crops, relies on groundwater for irrigation. We sampled 29 wells in the Ulagalla cascade, a prominent TCS near Anuradhapura city in the dry zone of Sri Lanka, in Yala (dry) and Maha (wet) seasons, the two main cropping seasons in Sri Lanka. We evaluated the suitability of groundwater for irrigation using the analytic hierarchy process and geographical information system. Water quality did not vary notably between seasons. However, it deteriorated with the onset of high intensity heavy rain, especially during the Maha season. A water quality zoning map indicated that groundwater in 4% and 96% of the study area is suitable and moderately suitable for irrigation, respectively. Irrigation water quality in tank cascade landscapes and similar environments can be assessed using this methodology and our results.

Description: Drought and heat-tolerant crops, such as Pearl millet (Pennisetum glaucum), are priority crops for fighting hunger in semi-arid regions. Assessing its performance under future climate scenarios is critical for determining its resilience and sustainability. Field experiments were conducted over two consecutive seasons (2015/2016 and 2016/2017) to determine the yield responses of the crop (pearl millet variety “Okoa”) to microdose fertilizer application in a semi-arid region of Tanzania. Data from the experiment were used to calibrate and validate the DSSAT model (CERES Millet). Subsequently, the model evaluated synthetic climate change scenarios for temperature increments and precipitation changes based on historic observations (2010–2018). Temperature increases of +0.5 to +3.0 °C (from baseline), under non-fertilized (NF) and fertilizer microdose (MD) conditions were used to evaluate nine planting dates of pearl millet from early (5 December) to late planting (25 February), based on increments of 10 days. The planting date with the highest yields was subjected to 49 synthetic scenarios of climate change for temperature increments and precipitation changes (of −30% up to +30% from baseline) to simulate yield responses. Results show that the model reproduced the phenology and yield, indicating a very good performance. Model simulations indicate that temperature increases negatively affected yields for all planting dates under NF and MD. Early and late planting windows were more negatively affected than the normal planting window, implying that temperature increases reduced the length of effective planting window for achieving high yields in both NF and MD. Farmers must adjust their planting timing, while the timely availability of seeds and fertilizer is critical. Precipitation increases had a positive effect on yields under all tested temperature increments, but Okoa cultivar only has steady yield increases up to a maximum of 1.5 °C, beyond which yields decline. This informs the need for further breeding or testing of other cultivars that are more heat tolerant. However, under MD, the temperature increments and precipitation change scenarios are higher than under NF, indicating a high potential of yield improvement under MD, especially with precipitation increases. Further investigation should focus on other cropping strategies such as the use of in-field rainwater harvesting and heat-tolerant cultivars to mitigate the effects of temperature increase and change in precipitation on pearl millet yield.

Description: Establishing food security in sub-Saharan African countries requires a comprehensive and high resolution understanding of the driving factors of crop production. Poor soil and adverse climate conditions are among the major drivers of poor regional crop production. Drought and rainfall variability challenges are not fully being addressed by rainfed producers in semiarid areas. In this study, we analysed the spatiotemporal rainfall variability (STRV) and its effects on pearl millet yield using two seasons of data collected from 38 rain gauge stations scattered randomly in farm plots within a 1500 ha area of semiarid central Tanzania. The STRV effects on pearl millet yield under flat and tied ridge management were analysed. Our results show that seasonal rainfall can vary significantly for neighboring fields at distances of less than 200 m, which impacts yield. The STRV for daily rainfall was found to be more critical than for total seasonal rainfall amounts. Scattering fields can help farmers avoid total harvest loss by obtaining at least some yield from the areas that received adequate rain. The use of tied ridges is recommended to conserve soil moisture and improve yields more than flat cultivation in semiarid areas.

Description: Rainfed agriculture constitutes around 80% of the world’s agricultural land, achieving the lowest on-farm crop yields and greatest on-farm water losses. Much of this land is in developing countries, including sub-Saharan Africa (SSA), where hunger is chronic. The primary constraint of rainfed agriculture—frequently experienced in SSA—is water scarcity, heightened by the unpredictability of season onset, erratic rainfall, as well as the inability of farmers to provide adequate soil and crop management. Farmers react differently to constraints, making a variety of choices—including the timing of planting, type of land cultivation, fertilization, and scattered fields, among many others. Limited information is available on the combined effects of these strategies for improving crop yield and water use efficiency (WUE). An experiment was co-conducted with farmers over four consecutive rainy seasons (2014–2018) in Tanzania, to evaluate these strategies for single and joint effects in improving yield and WUE on rainfed pearl millet (Pennisetum glaucum (L.) R.Br.). The treatments used were flat cultivation both without and with microdosing, as well as tied ridging without and with microdose interaction, with different planting dates depending on farmers’ decisions. Results show that farmers react differently to the early, normal, or late onset of the rainy season, and cumulative rainfall during its onset, which affects their decisions regarding planting dates, yield, and WUE. Microdose fertilization increases both the yield and WUE of pearl millet significantly, with greater effects obtained using tied ridging compared to flat cultivation. For low-income smallholder farmers in a semi-arid agroclimate, using tied ridging with microdosing during early planting is an effective response to spatiotemporal rainfall variability and poor soils.

Description: Disinfected water is the major source of haloacetic acids (HAAs) in humans, but their inter- and intra-individual variability for exposure and risk assessment applications is under-researched. Thus, we measured HAAs in cross-sectional and longitudinal urine and water specimens from 17 individuals. Five regulated HAAs—mono-, di-, and trichloroacetic acid (MCAA, DCAA, and TCAA) and mono- and dibromoacetic acid (MBAA and DBAA)—and one unregulated HAA—bromochloroacetic acid (BCAA)—were measured. Urinary DCAA, MBAA, DBAA, and BCAA levels were always below the limits of detection (LOD). Measured levels and interindividual variability of urinary MCAA were higher than urinary TCAA. Longitudinal urinary specimens showed MCAA levels peaked in after-shower specimens, while TCAA levels remain unchanged. Correlation between urinary MCAA and TCAA was moderate but statistically significant. The prevalence of MCAA and TCAA in urine suggest they can be considered as biomarkers of HAA. Peak urinary MCAA in post-shower specimens suggest MCAA captures short-term exposure via dermal and/or inhalation, while urinary TCAA captures long-term exposure via ingestion. However, further research is warranted in a large pool of participants to test the reliability of MCAA as exposure biomarker.

Description: Climate change, due to anthropogenic emissions of greenhouse gases, is driving policymakers to make decisions to promote more efficient energy use. Improved industrial energy efficiency is said to play a key role in the transition to more carbon-neutral energy systems. In most countries, industrial small and medium-sized enterprises (SMEs) represent 95% or more of the total number of companies. Thus, SMEs, apart from using energy, are a major driver in the economy with regard to innovation, GDP growth, employment, investments, exports, etc. Despite this, research and policy activities related to SMEs have been scarce, calling for contributions in the field. Therefore, the aim of this paper is to critically assess how adequate energy efficiency policy programmes for industrial SMEs could be designed. Results show that scientific publications in the field differ in scope and origin, but a major emphasis of the scientific papers has been on barriers to and drivers for energy efficiency. Scientific contributions from studies of energy policy programmes primarily cover energy audit programmes and show that the major energy efficiency measures from industrial SMEs are found in support processes. The review further reveals an imbalance in geographic scope of the papers within the field, where a vast majority of the papers emanate from Europe, calling for scientific publications from other parts of the world. The study synthesizes the findings into a general method on how to design efficiency programs for the sector.