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  • Articles  (6)
  • Oxford University Press  (4)
  • American Meteorological Society  (2)
  • 2015-2019  (6)
  • 1995-1999
  • 2019  (6)
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  • Articles  (6)
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  • 2015-2019  (6)
  • 1995-1999
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  • 1
    Publication Date: 2019-09-01
    Description: In contrast to the continuous increase in survival rates for many cancer entities, colorectal cancer (CRC) and pancreatic cancer are predicted to be ranked among the top 3 cancer-related deaths in the European Union by 2025. Especially, fighting metastasis still constitutes an obstacle to be overcome in CRC and pancreatic cancer. As described by Fearon and Vogelstein, the development of CRC is based on sequential mutations leading to the activation of proto-oncogenes and the inactivation of tumour suppressor genes. In pancreatic cancer, genetic alterations also attribute to tumour development and progression. Recent findings have identified new potentially important transcription factors in CRC, among those the activating transcription factor 2 (ATF2). ATF2 is a basic leucine zipper protein and is involved in physiological and developmental processes, as well as in tumorigenesis. The mutation burden of ATF2 in CRC and pancreatic cancer is rather negligible; however, previous studies in other tumours indicated that ATF2 expression level and subcellular localisation impact tumour progression and patient prognosis. In a tissue- and stimulus-dependent manner, ATF2 is activated by upstream kinases, dimerises and induces target gene expression. Dependent on its dimerisation partner, ATF2 homodimers or heterodimers bind to cAMP-response elements or activator protein 1 consensus motifs. Pioneering work has been performed in melanoma in which the dual role of ATF2 is best understood. Even though there is increasing interest in ATF2 recently, only little is known about its involvement in CRC and pancreatic cancer. In this review, we summarise the current understanding of the underestimated ‘cancer gene chameleon’ ATF2 in apoptosis, epithelial-to-mesenchymal transition and microRNA regulation and highlight its functions in CRC and pancreatic cancer. We further provide a novel ATF2 3D structure with key phosphorylation sites and an updated overview of all so-far available mouse models to study ATF2 in vivo.
    Print ISSN: 0267-8357
    Electronic ISSN: 1464-3804
    Topics: Biology , Medicine
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  • 2
    Publication Date: 2019-10-24
    Description: While different microalgae tend to be associated with different bacteria, it remains unclear whether such specific associations are beneficial for the microalgae. We assessed the impact of bacterial isolates, derived from various marine benthic diatoms, on the growth of several strains belonging to the Cylindrotheca closterium diatom species complex. We first tested the effect of 35 different bacterial isolates on the growth of a single C. closterium strain, and then evaluated the impact of 8 of these isolates on the growth of 6 C. closterium strains and 1 Cylindrotheca fusiformis strain. Surprisingly, most interactions were neutral to antagonistic. The interactions were highly specific, with diatom growth in the presence of specific bacteria differing between Cylindrotheca strains and species, and closely related bacteria eliciting contrasting diatom growth responses. These differences could be related to the origin of the bacterial isolates, as only isolates from foreign diatom hosts significantly reduced diatom growth, implying coadaptation between different Cylindrotheca strains and their associated bacteria. Interestingly, the antagonistic effect of a Marinobacter strain was alleviated by the presence of a microbial inoculum that was native to the diatom host, suggesting that coadapted bacteria might also benefit their host indirectly by preventing the establishment of harmful bacteria.
    Print ISSN: 0168-6496
    Electronic ISSN: 1574-6941
    Topics: Biology
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  • 3
    Publication Date: 2019-09-24
    Description: We present a detailed analysis of deep VLT/X-Shooter observations of the planetary nebula Tc 1. We calculate gas temperature, density, extinction, and abundances for several species from the empirical analysis of the total line fluxes. In addition, a spatially resolved analysis of the most intense lines provides the distribution of such quantities across the nebula. The new data reveal that several lines exhibit a double peak spectral profile consistent with the blue and redshifted components of an expanding spherical shell. The study of such components allowed us to construct for the first time a three-dimensional morphological model, which reveals that Tc 1 is a slightly elongated spheroid with an equatorial density enhancement seen almost pole on. A few bright lines present extended wings (with velocities up to a few hundred km s−1), but the mechanism producing them is not clear. We constructed photoionization models for the main shell of Tc 1. The models predict the central star temperature and luminosity, as well as the nebular density and abundances similar to previous studies. Our models indicate that Tc 1 is located at a distance of approximately 2 kpc. We report the first detection of the [Kr iii] 6825 Å emission line, from which we determine the Krypton abundance. Our model indicates that the main shell of Tc 1 is matter bounded; leaking H ionizing photons may explain the ionization of its faint AGB-remnant halo.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 4
    Publication Date: 2019-12-12
    Description: ROMS, a high-resolution regional ocean model, was used to study how climate change may affect the northwestern Atlantic Ocean. A control (CTRL) simulation was conducted for the recent past (1976–2005), and simulations with additional forcing at the surface and lateral boundaries, obtained from three different global climate models (GCMs) using the RCP8.5 scenario, were conducted to represent the future (2070–99). The climate change response was obtained from the difference between the CTRL and each of the three future simulations. All three ROMS simulations indicated large increases in sea surface temperatures (SSTs) over most of the domain except off the eastern U.S. seaboard resulting from weakening of the Gulf Stream. There are also substantial intermodel differences in the response, including a southward shift of the Gulf Stream in one simulation and a slight northward shift in the other two, with corresponding changes in eddy activity. The depth of maximum warming varied among the three simulations, resulting in differences in the bottom temperature response in coastal regions, including the Gulf of Maine and the West Florida Shelf. The surface salinity decreased in the northern part of the domain and increased in the south in all three experiments, although the freshening extended much farther south in one ROMS simulation relative to the other two, and also relative to the GCM that provided the large-scale forcing. Thus, while high resolution allows for a better representation of currents and bathymetry, the response to climate change can vary considerably depending on the large-scale forcing.
    Print ISSN: 0894-8755
    Electronic ISSN: 1520-0442
    Topics: Geography , Geosciences , Physics
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  • 5
    Publication Date: 2019-08-01
    Description: We compare a novel dataset of San Francisco Bay Area landslides from 1871 to 2012 to corresponding atmospheric conditions commonly associated with Pacific winter storms and landfalling atmospheric rivers (ARs). Landslides in the San Francisco Bay Area occur primarily during winter months, coinciding with enhanced integrated water vapor transport (IVT) magnitudes ≥250 kg m–1 s–1 at the coast 76% of the time and with landfalling ARs over the near-offshore northeast Pacific 82% of the time. Results illustrate that days, or the first in a series of days, with a landslide (i.e., landslide onset days) typically occur in association with NOAA Twentieth Century Reanalysis–derived IVT magnitudes ≥250 kg m–1 s–1 that persist for ∼20 h and temporal maxima in precipitation rates. Composite analyses of sea level pressure, integrated water vapor, and IVT during 3-month periods during September–May on landslide onset days further illustrate that these events coincide with regions of low pressure to the northwest of California and high pressure to the south, synoptic-scale flow conditions associated with strong onshore flow, and water vapor transports in the form of landfalling ARs.
    Print ISSN: 0003-0007
    Electronic ISSN: 1520-0477
    Topics: Geography , Physics
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  • 6
    Publication Date: 2019-08-01
    Description: The Upper Zone of the Rustenburg Layered Suite of the Bushveld Complex contains the world’s largest Fe–Ti–V ± P deposit and formed from the last major injection of magma into the chamber. Quantitative textural analysis of Upper Zone rocks was undertaken to constrain the processes operating during mush formation and solidification, focussing on horizons with the greatest density contrast to isolate the effects of gravitational loading. We examined three magnetitite layers, together with their underlying and overlying anorthosites. The similarity of microstructures in anorthosites above and below the dense magnetitite layers suggests that the rocks were not affected by viscous compaction driven by gravitational loading. The magnetitite cumulate layers formed by crystal accumulation from a mobile crystal slurry dominated by the Fe-rich conjugate of an unmixed immiscible liquid. We suggest a new mechanism of crystal nucleation in deforming crystal-rich systems, driven by undercooling caused by cavitation as grains slide past each other during simple shear. We propose that the super-solidus deformation recorded in these rocks was caused by prolonged regional subsidence of the magma chamber at Upper Zone times.
    Print ISSN: 0022-3530
    Electronic ISSN: 1460-2415
    Topics: Geosciences
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