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  • Molecular Diversity Preservation International  (7)
  • Oxford University Press  (6)
  • American Association for the Advancement of Science (AAAS)  (3)
  • American Institute of Physics
  • American Institute of Physics (AIP)
  • Amsterdam : Elsevier
  • Blackwell Science Ltd
  • 2015-2019  (17)
  • 2000-2004
  • 2019  (17)
Collection
Publisher
Years
  • 2015-2019  (17)
  • 2000-2004
Year
  • 1
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    Impedance spectroscopy characterization of neutron irradiated thermoelectric modules for space nuclear power (2019)
    American Institute of Physics
    Details
    Publication Date: 2019-05-01
    Electronic ISSN: 2158-3226
    Topics: Physics
    Published by American Institute of Physics
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  • 2
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    Hierarchical interlocked orthogonal faulting in the 2019 Ridgecrest earthquake sequence (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉 A nearly 20-year hiatus in major seismic activity in southern California ended on 4 July 2019 with a sequence of intersecting earthquakes near the city of Ridgecrest, California. This sequence included a foreshock with a moment magnitude (〈i〉M〈/i〉〈sub〉w〈/sub〉) of 6.4 followed by a 〈i〉M〈/i〉〈sub〉w〈/sub〉 7.1 mainshock nearly 34 hours later. Geodetic, seismic, and seismicity data provided an integrative view of this sequence, which ruptured an unmapped multiscale network of interlaced orthogonal faults. This complex fault geometry persists over the entire seismogenic depth range. The rupture of the mainshock terminated only a few kilometers from the major regional Garlock fault, triggering shallow creep and a substantial earthquake swarm. The repeated occurrence of multifault ruptures, as revealed by modern instrumentation and analysis techniques, poses a formidable challenge in quantifying regional seismic hazards.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A Bayesian Monte-Carlo Inversion of Spatial Auto-Correlation (SPAC) for Near-Surface Vs Structure Applied to both Broadband and Geophone Data (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉Summary〈/div〉We propose a new Bayesian method to reveal the 〈span〉Vs〈/span〉 structure of the near surface of the earth using spatial autocorrelation (SPAC) functions and apply this new method to synthetic, broadband, and geophone datasets. The principle of SPAC is introduced, and an implementation of the Bayesian Monte Carlo inversion (BMCI) for modeling SPAC coherency functions is described. To demonstrate its effectiveness, BMCI is applied to synthetic tests, data from 14 SPAC array sites in the Salt Lake Valley (SLV), Utah, and two arrays (one broadband and one geophone) located in south central Utah. The 〈span〉Vs〈/span〉 models derived from previous SPAC analysis of the 14 SLV sites differ by 10 per cent at most from those determined by BMCI and lie within uncertainties determined for the BMCI models. These agreements demonstrate the effectiveness of the BMCI method. The synthetic tests and applications to the SLV SPAC data show BMCI has great potential to resolve 〈span〉Vs〈/span〉 structure down to at least 400 m. To achieve resolution for deeper 〈span〉Vs〈/span〉 structure, longer duration deployments, wider array apertures, and additional seismometers or geophones can be employed. Additionally, when the target frequencies are greater than 0.1 Hz, there is no apparent disadvantage in using geophone data for BMCI compared to broadband data. Most significantly, BMCI places a quantifiable constraint on the uncertainties of the 〈span〉Vs〈/span〉 models as well as 〈span〉Vs30〈/span〉.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 4
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    Characterization of crustal structure by comparing reflectivity patterns of wide-angle and near vertical seismic data from the Parnaíba Basin, Brazil (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉SUMMARY〈/div〉Recently an ambitious experiment combining deep seismic surveys from near-vertical and wide-angle acquisition methods was carried out in Brazil. The seismic lines are essentially coincident and crossed the Parnaíba Basin from west to east near latitude 5°S. Here, the wide-angle reflection and refraction (WARR) and deep seismic reflection (DSR) results, which were previously interpreted independently, are compared by directly correlating WARR interfaces converted to TWTT with the major reflective horizons identified in the zero-offset image and by considering coincident reflectivity patterns displayed in both data sets. This integrated WARR and DSR analysis allowed a spatial association of the apparently acoustically featureless crust imaged in the DSR profile to the high reflectivity observed in the WARR data. Numerical tests and elastic modelling show that variations of the elastic properties of the crust, particularly as they are characterized by low 〈span〉Vp〈/span〉 and 〈span〉Vs〈/span〉 contrasts with a possible increase of the 〈span〉Vp〈/span〉/〈span〉Vs〈/span〉 ratio, can only weakly explain the observed reflectivity patterns but that fine-scale lithological heterogeneity within the crust is capable of replicating the observed contrasting seismic responses. The segment of the Parnaíba Basin crust that is characterized by fine-scale lithological heterogeneity lies directly above a mafic crustal underplate defined by the WARR model and was named as the Grajaú domain on the basis of WARR-derived velocity model. The applied methodologies allow added value to be taken from the independent seismic data sets and provide new information about crustal structure that may have important implications for overlying intracontinental basin evolution.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 5
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    A new case of kleptoplasty in animals: Marine flatworms steal functional plastids from diatoms (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉To date, sea slugs have been considered the only animals known to sequester functional algal plastids into their own cells, via a process called "kleptoplasty." We report here, however, that endosymbionts in the marine flatworms 〈i〉Baicalellia solaris〈/i〉 and 〈i〉Pogaina paranygulgus〈/i〉 are isolated plastids stolen from diatoms. Ultrastructural data show that kleptoplasts are located within flatworm cells, while algal nuclei and other organelles are absent. Transcriptomic analysis and 〈i〉rbcL〈/i〉 amplicons confirm the absence of algal nuclear mRNA and reveal that the plastids originate from different species of diatoms. Laboratory experiments demonstrated photosynthetic activity and short-term retention of kleptoplasts in starved worms. This lineage of flatworms represents the first known case of functional kleptoplasty involving diatoms and only the second known case of kleptoplasty across the entire tree of animals.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Spatiotemporal immune zonation of the human kidney (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Tissue-resident immune cells are important for organ homeostasis and defense. The epithelium may contribute to these functions directly or by cross-talk with immune cells. We used single-cell RNA sequencing to resolve the spatiotemporal immune topology of the human kidney. We reveal anatomically defined expression patterns of immune genes within the epithelial compartment, with antimicrobial peptide transcripts evident in pelvic epithelium in the mature, but not fetal, kidney. A network of tissue-resident myeloid and lymphoid immune cells was evident in both fetal and mature kidney, with postnatal acquisition of transcriptional programs that promote infection-defense capabilities. Epithelial-immune cross-talk orchestrated localization of antibacterial macrophages and neutrophils to the regions of the kidney most susceptible to infection. Overall, our study provides a global overview of how the immune landscape of the human kidney is zonated to counter the dominant immunological challenge.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Characterisation of crustal structure by comparing reflectivity patterns of wide-angle and near vertical seismic data from the Parnaíba Basin, Brazil (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉Summary〈/div〉Recently an ambitious experiment combining deep seismic surveys from near-vertical and wide-angle acquisition methods was carried out in Brazil. The seismic lines are essentially coincident and crossed the Parnaíba Basin from west to east near latitude 5° S. Here, the wide-angle reflection and refraction (WARR) and deep seismic reflection (DSR) results, which were previously interpreted independently, are compared by directly correlating WARR interfaces converted to TWTT with the major reflective horizons identified in the zero-offset image and by considering coincident reflectivity patterns displayed in both data sets. This integrated WARR and DSR analysis allowed a spatial association of the apparently acoustically featureless crust imaged in the DSR profile to the high reflectivity observed in the WARR data. Numerical tests and elastic modelling show that variations of the elastic properties of the crust, particularly as they are characterised by low 〈span〉V〈/span〉p and 〈span〉V〈/span〉s contrasts with a possible increase of the 〈span〉V〈/span〉p/〈span〉V〈/span〉s ratio, can only weakly explain the observed reflectivity patterns but that fine-scale lithological heterogeneity within the crust is capable of replicating the observed contrasting seismic responses. The segment of the Parnaíba Basin crust that is characterised by fine-scale lithological heterogeneity lies directly above a mafic crustal underplate defined by the WARR model and was named as the Grajaú domain on the basis of WARR-derived velocity model. The applied methodologies allow added value to be taken from the independent seismic datasets and provide new information about crustal structure that may have important implications for overlying intracontinental basin evolution.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 8
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    Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration (2019)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2019-06-29
    Description: We examined whether gastric acidity would affect the activity of myrosinase, co-delivered with glucoraphanin (GR), to convert GR to sulforaphane (SF). A broccoli seed and sprout extract (BSE) rich in GR and active myrosinase was delivered before and after participants began taking the anti-acid omeprazole, a potent proton pump inhibitor. Gastric acidity appears to attenuate GR bioavailability, as evidenced by more SF and its metabolites being excreted after participants started taking omeprazole. Enteric coating enhanced conversion of GR to SF, perhaps by sparing myrosinase from the acidity of the stomach. There were negligible effects of age, sex, ethnicity, BMI, vegetable consumption, and bowel movement frequency and quality. Greater body mass correlated with reduced conversion efficiency. Changes in the expression of 20 genes in peripheral blood mononuclear cells were evaluated as possible pharmacodynamic indicators. When grouped by their primary functions based on a priori knowledge, expression of genes associated with inflammation decreased non-significantly, and those genes associated with cytoprotection, detoxification and antioxidant functions increased significantly with bioavailability. Using principal components analysis, component loadings of the changes in gene expression confirmed these groupings in a sensitivity analysis.
    Electronic ISSN: 2072-6643
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 9
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    A Strategy to Deliver Precise Oral Doses of the Glucosinolates or Isothiocyanates from Moringa oleifera Leaves for Use in Clinical Studies (2019)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2019-07-09
    Description: The tropical tree Moringa oleifera produces high yields of protein-rich leaf biomass, is widely used as a food source, contains an abundance of phytochemicals, and thus has great potential for chronic disease prevention and perhaps, treatment. We have developed and characterized standardized ways of preparing aqueous “teas” from moringa leaves to deliver precisely calibrated levels of phytochemicals for use in clinical trials. These phytochemicals, especially the glucosinolate glucomoringin and the isothiocyanate moringin, produced from it following hydrolysis by the enzyme myrosinase, provide potent anti-inflammatory and cytoprotective indirect antioxidant activity. The taste of both hot and cold teas is palatable without the need for flavor masking. These teas can be easily and reproducibly prepared in underserved tropical regions of the world where moringa is cultivated. Isothiocyanate yield from a cold extraction was rapid and essentially complete after 30 min and its anti-inflammatory potential is comparable to that of equimolar purified moringin. A preparation similar to this may be safe to consume with respect to its bacterial titer even after 48 h without refrigeration. Thus, facile delivery of moringa tea to both adults and children for clinical evaluation of their effects on such conditions as autism, diabetes, and hypertension, is now possible.
    Electronic ISSN: 2072-6643
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 10
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    Consumption of Animal-Source Protein is Associated with Improved Height-for-Age z Scores in Rural Malawian Children Aged 12–36 Months (2019)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2019-02-25
    Description: Linear growth faltering, caused by insufficient diet, recurrent infections and environmental enteric dysfunction (EED), continues to plague young children in low- and middle-income countries (LMICs). Diets in LMICs are primarily plant based, and thus have poor-quality protein and low levels of essential micronutrients. The aim of this study was to assess the association of the type and protein quality of food consumed with stunting, EED and acute malnutrition in children aged 6–36 months in Limera and Masenjere, two rural Southern Malawian communities. This is a secondary analysis of two randomized controlled trials that tested the effects of common bean and cowpea flour on stunting in children aged 6–36 months. We used data from two interactive 24-h dietary recalls conducted 12 weeks after enrolment into each trial. Food intakes were compared between the regions using Chi-square and Student’s t-test. There were 355 children that participated in the dietary recalls. The diets of children were of poor quality, but the children from Limera consumed more fish (54% vs. 35%, p = 0.009) and more bioavailable protein (26.0 ± 10.3 g/day vs. 23.1 ± 8.1 g/day, p = 0.018, respectively) than children in Masenjere. Food type and protein quality were not associated with any of the outcomes except an association between animal protein consumption and improvement in height-for-age z scores in children aged 12–36 months (p = 0.047). These findings support the notion that animal-source food (ASF) consumption in this vulnerable population promotes linear growth.
    Electronic ISSN: 2072-6643
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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