Publication Date:
2018-08-23
Description:
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies, Published online: 22 August 2018; doi:10.1038/s41467-018-05482-0 The highly conserved influenza virus hemagglutinin (HA) stalk represents a potential target for a broadly protective vaccine. Here, the authors show that immunization with nucleoside-modified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and protects from heterosubtypic virus infection.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
Permalink