Publication Date:
2018
Description:
In mammalian cells, the decision to maintain quiescence over proliferation commitment during G1‐S transition depends on more than one intertwined feedback interaction and is highly cell‐type dependent. However, the precise role played by these individual feedback regulations in organizing such diverse proliferation dynamics is still poorly understood. Herein, we propose a predictive mathematical model of G1‐S transition in mammalian cells that reconciles distinct single‐cell experimental observations in a cell‐type specific manner. The model analysis reveals that the feedback motifs responsible for the G1‐S transition act in a disparate fashion to organize the cell‐type specific proliferation response. Importantly, the proposed model can be effectively tuned to gain insights into the proliferation commitment of diverse mammalian cell types and can find wide applicability.
Print ISSN:
0014-5793
Electronic ISSN:
1873-3468
Topics:
Biology
,
Chemistry and Pharmacology
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