Publication Date:
2017-12-07
Description:
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation, Published online: 06 December 2017; doi:10.1038/s41467-017-01489-1 G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the mGlu2 receptor.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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