Publication Date:
2017-09-29
Description:
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner Nature Communications, Published online: 28 September 2017; doi:10.1038/s41467-017-00769-0 Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ signal.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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