Publication Date:
2017-07-13
Description:
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy Nature Communications, Published online: 12 July 2017; doi:10.1038/s41467-017-00057-x Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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