Publication Date:
2016-04-28
Description:
A one-pot transformation, which involves the reaction of ketones with aldehydes in the presence of metal halides to furnish tetrahydro-2 H -pyran-2,4-diols in a highly diastereoselective manner, is investigated thoroughly by experiments and computations. The reaction was also successfully implemented on a flow micro reactor system. Beilstein J. Org. Chem. 2016, 12, 813–824. doi:10.3762/bjoc.12.80
Keywords:
DFTdiastereoselective reactiondomino aldolmetal enolatetetrahydropyran
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
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