ALBERT

Description: Well defined productivity-precipitation relationships of ecosystems are needed as benchmarks for the validation of land-models used for future projections. The productivity-precipitation relationship may be studied in two ways: the spatial approach relates differences in productivity to those in precipitation among sites along a precipitation gradient (the spatial fit, with a steeper slope); the temporal approach relates inter-annual productivity changes to variation in precipitation within sites (the temporal fits, with flatter slopes). Precipitation-reduction experiments in natural ecosystems represent a complement to the fits, because they can reduce precipitation below the natural range and are thus well suited to study potential effects of climate drying. Here, we analyze the effects of dry treatments in eleven multi-year precipitation-manipulation experiments, focusing on changes in the temporal fit. We expected that structural changes in the dry treatments would occur in some experiments, thereby reducing the intercept of the temporal fit and displacing the productivity-precipitation relationship downward the spatial fit. The majority of experiments (72%) showed that dry treatments did not alter the temporal fit. This implies that current temporal fits are to be preferred over the spatial fit to benchmark land-model projections of productivity under future climate within the precipitation ranges covered by the experiments. Moreover, in two experiments, the intercept of the temporal fit unexpectedly increased due to mechanisms that reduced either water- or nutrient losses. The expected decrease of the intercept was observed in only one experiment, and only when distinguishing between the late and the early phases of the experiment. This implies that we currently do not know at which precipitation-reduction level or at which experimental duration structural changes will start to alter ecosystem productivity. Our study highlights the need for experiments with multiple, including more extreme, dry treatments, to identify the precipitation boundaries within which the current temporal fits remain valid. This article is protected by copyright. All rights reserved.

Description: Coinductive definitions, such as that of an infinite stream, may often be described by elegant logic programs, but ones for which SLD-refutation is of no value as SLD-derivations fall into infinite loops. Such definitions give rise to questions of lazy corecursive derivations and parallelism, as execution of such logic programs can have both recursive and corecursive features at once. Observational and coalgebraic semantics have been used to study them abstractly. The programming developments have often occurred separately and have usually been implementation-led. Here, we give a coherent semantics-led account of the issues, starting with abstract category theoretic semantics, developing coalgebra to characterize naturally arising trees and proceeding towards implementation of a new dialect, CoALP, of logic programming, characterised by guarded lazy corecursion and parallelism.

Description: : Intrinsically disordered proteins (IDPs) play central roles in many biological processes. Consequently, an accurate description of the disordered state is an important step towards a comprehensive understanding of a number of important biological functions. In this work we describe a new web server, Mollack, for the automated construction of unfolded ensembles that uses both experimental and molecular simulation data to construct models for the unfolded state. An important aspect of the method is that it calculates a quantitative estimate of the uncertainty in the constructed ensemble, thereby providing an objective measure of the quality of the final model. Overall, Mollack facilitates structure-function studies of disordered proteins. Availability and Implementation: http://cmstultz-mollack.mit.edu Contact: cmstultz@mit.edu Supplementary information: Supplementary data are available at Bioinformatics online.

Description: Candida albicans is a dimorphic yeast commonly found on human mucosal membranes that switches from yeast to hyphal morphology in response to environmental factors. The change to hyphal growth requires histone H3 modifications by the yeast-specific histone acetyltransferase Rtt109. In addition to its role in morphogenesis, Rtt109-dependent acetylation of histone H3 lysine residues 9 and 56 has regulatory functions during DNA replication and repair. Boric acid (BA) is a broad-spectrum agent that specifically inhibits C. albicans hyphal growth, locking the fungus in its harmless commensal yeast state. The present study characterizes the effect of BA on C. albicans histone acetylation in respect to specificity, time-course and significance. We demonstrate that sublethal concentrations of BA reduce H3K9/H3K56 acetylation, both on a basal level and in response to genotoxic stress. Acetylation at other selected histone sites were not affected by BA. qRT-PCR expression analysis of the DNA repair gene Rad51 indicated no elevated level of genotoxic stress during BA exposure. A forward-mutation analysis demonstrated the BA does not increase spontaneous or induced mutations . The findings suggest that DNA repair remains effective even when histone H3 acetylation decreases and dispels the notion that BA treatment impairs genome integrity in yeast.

Description: We introduce the moduli space of spectral curves of constant mean curvature (CMC) cylinders of finite type in the round unit 3-sphere. The subset of spectral curves of mean-convex Alexandrov embedded cylinders is explicitly determined using a combination of integrable systems and geometric analysis techniques. We prove that these cylinders are surfaces of revolution. As a consequence, all mean-convex Alexandrov embedded CMC tori in the 3-sphere are surfaces of revolution.

Description: Comet 67P/Churyumov-Gerasimenko (67P) was imaged with the 2 m telescope at Mt. Wendelstein Observatory in the Alps. Coma and tail monitoring was performed during 51 nights between 2015 August 22 and 2016 May 9. The images through r and i Sloan Digital Sky Survey (SDSS) filters show the dust distribution around the comet, while images in the SDSS g filter also indicate the presence of coma gas in early 2015 September. The dust colour of 67P implies intrinsic reddening of 9 per cent/100 nm. After maximum, shortly after perihelion passage, the dust activity decreased with a heliocentric exponent of 4.1–4.2 from late 2015 September until 2016 May. The opposition surge during early 2016 can be explained by a linear light scattering phase function (β ~ 0.04) or an asteroid-like HG-type phase function ( G ~ 0.15). The radial brightness profile indicates a ‘quasi-steady-state’ dust coma from late September to the end of 2015. Dust fragmentation during about a month after perihelion may be responsible for radial coma profiles with slopes below unity, while dust accumulation due to very slow dust expansion velocity may result in steeper than unity profiles during 2016. Three fan-shape dust structures are characterized in the coma of 67P. A short dust ejection event on 2015 August 22–23 has produced a dust arc-let and jet feature in the coma. In 2015 September, the appearance of cometary dust tail is dominated by the young dust produced around perihelion. The older dust dominates the tail appearance as of 2015 mid-November.

Description: We present a simple observation showing that the heat kernel on a locally finite graph behaves for short times $t$ roughly like $t^d$ , where $d$ is the combinatorial distance. This is very different from the classical Varadhan-type behavior on manifolds. Moreover, this also gives that short-time behavior and global behavior of the heat kernel are governed by two different metrics whenever the degree of the graph is not uniformly bounded.

Description: We have developed a probabilistic model to simulate the fate and transport of non-conservative constituents in urban watersheds. The approach implemented here extends previous studies that rely on the Geomorphological Instantaneous Unit Hydrograph concept to include non-conservative constituents. This is implemented with a factor χ that affects the transfer functions and therefore accounts for the loss (gain) of mass associated with the constituent as it travels through the watershed. Using this framework we developed an analytical solution for the dynamics of dissolved oxygen (DO) and biochemical oxygen demand (BOD) in urban networks based on the Streeter and Phelps model. This model breaks-down the catchment into a discreet number of possible flow paths through the system, requiring less data and implementation effort than well-established deterministic models. Application of the model to one sewer catchment in the Chicago area with available BOD information proved its ability to predict the BOD concentration observed in the measurements. In addition, comparison of the model with a calibrated Storm Water Management Model (SWMM) of another sewer catchment from the Chicago area showed that the model predicted the BOD concentration as well as the widely accepted SWMM. The developed model proved to be a suitable alternative to simulate the fate and transport of constituents in urban catchments with limited and uncertain input data. This article is protected by copyright. All rights reserved.