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  • American Association for the Advancement of Science (AAAS)
  • 2015-2019  (12)
  • 2019  (9)
  • 2016  (3)
  • 1
    Publication Date: 2019
    Description: 〈p〉The epoch of first star formation in the early Universe was dominated by simple atomic and molecular species consisting mainly of two elements: hydrogen and helium. Gaining insight into this constitutive era requires a thorough understanding of molecular reactivity under primordial conditions. We used a cryogenic ion storage ring combined with a merged electron beam to measure state-specific rate coefficients of dissociative recombination, a process by which electrons destroy molecular ions. We found a pronounced decrease of the electron recombination rates for the lowest rotational states of the helium hydride ion (HeH〈sup〉+〈/sup〉), compared with previous measurements at room temperature. The reduced destruction of cold HeH〈sup〉+〈/sup〉 translates into an enhanced abundance of this primordial molecule at redshifts of first star and galaxy formation.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2019
    Description: 〈p〉Aversive affect is likely a key source of irrational human decision-making, but still, little is known about the neural circuitry underlying emotion-cognition interactions during social behavior. We induced incidental aversive affect via prolonged periods of threat of shock, while 41 healthy participants made investment decisions concerning another person or a lottery. Negative affect reduced trust, suppressed trust-specific activity in the left temporoparietal junction (TPJ), and reduced functional connectivity between the TPJ and emotion-related regions such as the amygdala. The posterior superior temporal sulcus (pSTS) seems to play a key role in mediating the impact of affect on behavior: Functional connectivity of this brain area with left TPJ was associated with trust in the absence of negative affect, but aversive affect disrupted this association between TPJ-pSTS connectivity and behavioral trust. Our findings may be useful for a better understanding of the neural circuitry of affective distortions in healthy and pathological populations.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 3
    Publication Date: 2019
    Description: 〈p〉The epoch of first star formation in the early universe was dominated by simple atomic and molecular species consisting mainly of two elements: hydrogen and helium. Gaining insight into this constitutive era requires thorough understanding of molecular reactivity under primordial conditions. We used a cryogenic ion storage ring combined with a merged electron beam to measure state-specific rate coefficients of dissociative recombination, a process by which electrons destroy molecular ions. We found a dramatic decrease of the electron recombination rates for the lowest rotational states of HeH〈sup〉+〈/sup〉, compared to previous measurements at room temperature. The reduced destruction of cold HeH〈sup〉+〈/sup〉 translates into an enhanced abundance of this primordial molecule at redshifts of first star and galaxy formation.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Natural Sciences in General
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  • 4
    Publication Date: 2019
    Description: 〈p〉We report DNA- and RNA-like systems built from eight nucleotide "letters" (hence the name "hachimoji") that form four orthogonal pairs. These synthetic systems meet the structural requirements needed to support Darwinian evolution, including a polyelectrolyte backbone, predictable thermodynamic stability, and stereoregular building blocks that fit a Schrödinger aperiodic crystal. Measured thermodynamic parameters predict the stability of hachimoji duplexes, allowing hachimoji DNA to increase the information density of natural terran DNA. Three crystal structures show that the synthetic building blocks do not perturb the aperiodic crystal seen in the DNA double helix. Hachimoji DNA was then transcribed to give hachimoji RNA in the form of a functioning fluorescent hachimoji aptamer. These results expand the scope of molecular structures that might support life, including life throughout the cosmos.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2019
    Description: 〈p〉Stearns and van der Veen (Reports, 20 July 2018, p. 273) conclude that fast glacier sliding is independent of basal drag (friction), even where drag balances most of the driving stress. This conclusion raises fundamental physical issues, the most striking of which is that sliding velocity would be independent of stresses imparted through the ice column, including gravitational driving stress.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2019
    Description: 〈p〉Using a mid-infrared emission spectrometer based on a superconducting nanowire single-photon detector, we observed the dynamics of vibrational energy pooling of carbon monoxide (CO) adsorbed at the surface of a sodium chloride (NaCl) crystal. After exciting a majority of the CO molecules to their first vibrationally excited state (v = 1), we observed infrared emission from states up to v = 27. Kinetic Monte Carlo simulations showed that vibrational energy collects in a few CO molecules at the expense of those up to eight lattice sites away by selective excitation of NaCl’s transverse phonons. The vibrating CO molecules behave like classical oscillating dipoles, losing their energy to NaCl lattice vibrations via the electromagnetic near-field. This is analogous to Sommerfeld’s description of radio transmission along Earth’s surface by ground waves.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2016-02-26
    Description: Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There, competition between B cell clones and among somatic mutants of each clone drives an increase in average affinity across the population. The extent to which higher-affinity cells eliminating competitors restricts clonal diversity is unknown. By combining multiphoton microscopy and sequencing, we show that tens to hundreds of distinct B cell clones seed each GC and that GCs lose clonal diversity at widely disparate rates. Furthermore, efficient affinity maturation can occur in the absence of homogenizing selection, ensuring that many clones can mature in parallel within the same GC. Our findings have implications for development of vaccines in which antibodies with nonimmunodominant specificities must be elicited, as is the case for HIV-1 and influenza.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tas, Jeroen M J -- Mesin, Luka -- Pasqual, Giulia -- Targ, Sasha -- Jacobsen, Johanne T -- Mano, Yasuko M -- Chen, Casie S -- Weill, Jean-Claude -- Reynaud, Claude-Agnes -- Browne, Edward P -- Meyer-Hermann, Michael -- Victora, Gabriel D -- 5DP5OD012146/OD/NIH HHS/ -- S10 OD016326/OD/NIH HHS/ -- New York, N.Y. -- Science. 2016 Mar 4;351(6277):1048-54. doi: 10.1126/science.aad3439. Epub 2016 Feb 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. ; Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Sorbonne Paris Cite, Universite Paris Descartes, Faculte de Medecine-Site Broussais, 75014 Paris, France. ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02142, USA. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ; Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Inhoffenstrabetae7, 38124 Braunschweig, Germany. Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universitat Braunschweig, Braunschweig, Germany. ; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. victora@wi.mit.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26912368" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2016-02-27
    Description: The state of vanishing friction known as superlubricity has important applications for energy saving and increasing the lifetime of devices. Superlubricity, as detected with atomic force microscopy, appears when sliding large graphite flakes or gold nanoclusters across surfaces, for example. However, the origin of the behavior is poorly understood because of the lack of a controllable nanocontact. We demonstrated the superlubricity of graphene nanoribbons when sliding on gold with a joint experimental and computational approach. The atomically well-defined contact allows us to trace the origin of superlubricity, unraveling the role played by ribbon size and elasticity, as well as by surface reconstruction. Our results pave the way to the scale-up of superlubricity and thus to the realization of frictionless coatings.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kawai, Shigeki -- Benassi, Andrea -- Gnecco, Enrico -- Sode, Hajo -- Pawlak, Remy -- Feng, Xinliang -- Mullen, Klaus -- Passerone, Daniele -- Pignedoli, Carlo A -- Ruffieux, Pascal -- Fasel, Roman -- Meyer, Ernst -- New York, N.Y. -- Science. 2016 Feb 26;351(6276):957-61. doi: 10.1126/science.aad3569.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Basel, Klingelbergstrasse 82, CH-4056 Basel, Switzerland. PRESTO (Precursory Research for Embryonic Science and Technology), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. ; nanotech@surfaces Laboratory, Empa, Swiss Federal Laboratories for Materials Science and Technology, Uberlandstrasse 129, 8600 Dubendorf, Switzerland. Institute for Materials Science and Max Bergmann Center of Biomaterials, Technische Universitat Dresden, 01062 Dresden, Germany. ; Instituto Madrileno de Estudios Avanzados en Nanociencia, 28049 Madrid, Spain. Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, 07743 Jena, Germany. ; nanotech@surfaces Laboratory, Empa, Swiss Federal Laboratories for Materials Science and Technology, Uberlandstrasse 129, 8600 Dubendorf, Switzerland. ; Department of Physics, University of Basel, Klingelbergstrasse 82, CH-4056 Basel, Switzerland. ; Department of Chemistry and Food Chemistry, Center for Advancing Electronics Dresden, Technische Universitat Dresden, 01062 Dresden, Germany. ; Max Planck Institute for Polymer Research, 55124 Mainz, Germany. ; nanotech@surfaces Laboratory, Empa, Swiss Federal Laboratories for Materials Science and Technology, Uberlandstrasse 129, 8600 Dubendorf, Switzerland. Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26917767" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2016-12-09
    Description: Understanding the conditions that allow speciation to occur is difficult because most research has focused on either long-lived organisms or asexual microorganisms. We propagated bacteriophage λ, a virus with rapid generations and frequent recombination, on two Escherichia coli host genotypes that expressed either the LamB or OmpF receptor. When supplied with either single host (allopatry), phage λ improved its binding to the available receptor while losing its ability to use the alternative. When evolving on both hosts together (sympatry), the viruses split into two lineages with divergent receptor preferences. Although the level of divergence varied among replicates, some lineages evolved reproductive isolation via genetic incompatibilities. This outcome indicates that, under suitable conditions, allopatric and sympatric speciation can occur with similar ease. Authors: Justin R. Meyer, Devin T. Dobias, Sarah J. Medina, Lisa Servilio, Animesh Gupta, Richard E. Lenski
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2019
    Description: 〈p〉Until the 19th century, lead white was the most important white pigment used in oil paintings. Lead white is typically composed of two crystalline lead carbonates: hydrocerussite [2PbCO〈sub〉3〈/sub〉·Pb(OH)〈sub〉2〈/sub〉] and cerussite (PbCO〈sub〉3〈/sub〉). Depending on the ratio between hydrocerussite and cerussite, lead white can be classified into different subtypes, each with different optical properties. Current methods to investigate and differentiate between lead white subtypes involve invasive sampling on a microscopic scale, introducing problems of paint damage and representativeness. In this study, a 17th century painting 〈i〉Girl with a Pearl Earring〈/i〉 (by Johannes Vermeer, c. 1665, collection of the Mauritshuis, NL) was analyzed with a recently developed mobile and noninvasive macroscopic x-ray powder diffraction (MA-XRPD) scanner within the project 〈i〉Girl in the Spotlight〈/i〉. Four different subtypes of lead white were identified using XRPD imaging at the macroscopic and microscopic scale, implying that Vermeer was highly discriminatory in his use of lead white.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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