Publication Date:
2016-04-28
Description:
Article Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitro and accelerate remyelination in mice following focal demyelination. Nature Communications doi: 10.1038/ncomms11312 Authors: Michael B. Keough, James A. Rogers, Ping Zhang, Samuel K. Jensen, Erin L. Stephenson, Tieyu Chen, Mitchel G. Hurlbert, Lorraine W. Lau, Khalil S. Rawji, Jason R. Plemel, Marcus Koch, Chang-Chun Ling, V. Wee Yong
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
Permalink