Publikationsdatum:
2015-11-25
Beschreibung:
Article Protein fusions between MLL and AEP (AF4 family/ENL family/P-TEFb) constitutively activate their target genes to immortalize hematopoietic progenitors. Here, Okuda et al . show that MLL-AEP binds SL1, a component of the pre-initiation complex of RNA polymerase (RNAP) I, to initiate RNAP II dependent transcription. Nature Communications doi: 10.1038/ncomms9869 Authors: Hiroshi Okuda, Akinori Kanai, Shinji Ito, Hirotaka Matsui, Akihiko Yokoyama
Digitale ISSN:
2041-1723
Thema:
Biologie
,
Chemie und Pharmazie
,
Allgemeine Naturwissenschaft
,
Physik
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